scholarly journals A study of febrile seizures in children in relation to iron deficiency anemia

2017 ◽  
Vol 4 (5) ◽  
pp. 1599
Author(s):  
Gautam Shah ◽  
Ritesh Parmar
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Sample Size ◽  
Iron Deficiency Anemia ◽  
Odds Ratio ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Large Sample Size ◽  
Febrile Convulsions

Background: Febrile seizures are the most common cause of convulsions in children between 6 months to 5 years, occurring in 2-5% of children. Iron deficiency is postulated as a risk factor for febrile seizures in children and it is an easily correctable condition. The objective of the study was to study the clinical profile and risk factors of febrile convulsions and to establish an association between febrile seizure and iron deficiency anemia.Methods: The study was carried out in Department of Pediatrics, Dhiraj General Hospital, Piparia, a tertiary care teaching hospital. 34 cases and 34 controls were included in the study. Controls were children of same age group presenting with short febrile illness but without any seizures. Febrile seizures were defined according to the AAP (American Academy of Pediatrics) criteria. Iron deficiency was diagnosed by hematologic investigations of haemoglobin value < 11 g/dl, MCV <70 fL and RDW > 15.6%.Results: Iron deficiency anemia was present in 23.52% (8/34) of cases as compared to 17.64% (6/34) in the control group. Odds ratio was 1.436 (95% CI 0.439-4.669, p value 0.549), which suggest there is no significant association of iron deficiency anemia with febrile convulsions. Subgroup analysis for association of iron deficiency anemia with simple febrile convulsion cases showed Odds ratio of 1.11 (95% CI 0.298-4.138), which suggests there is poor association of iron deficiency anemia with simple febrile convulsions. Subgroup analysis for association of iron deficiency anemia with complex febrile convulsion cases showed Odds ratio of 2.809 (95% CI 0.521-15.041), which suggests there is poor association of iron deficiency anemia with complex febrile convulsions. Wide confidence interval indicates less sample size. Study with large sample size is required for reliable interpretation.Conclusions:The study reveals iron deficiency anemia is not a significant risk factor in children presenting with febrile seizures. Further study with large sample size is required. 

scholarly journals A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

2020 ◽  
pp. 1-3
Author(s):  
Lakshmi M ◽  
Sumapriya M ◽  
Channamsetty Anusha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

scholarly journals Febrile Convulsions in Anemic Children: A Review

2021 ◽  
pp. 392-399
Author(s):  
Hassan Tag Elkhatim Mohamed ◽  
Ibtisam Khulaif Alruwaili ◽  
Maisa Hamad Freaj Alenazi ◽  
Ahlam sultan Alanazi ◽  
Norah Thyap Matar Alenezi
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Common Type ◽  
Deficiency Anemia ◽  
Febrile Convulsions ◽  
Number Of Children ◽  
Children Under 5

Febrile convulsions are the most common type of convulsions that affect children aged 6 months to 5 years old. Iron deficiency anemia could be a risk factor for febrile convulsions as was suggested by some studies, for the reason that febrile convulsions is common in children under 5 years and iron deficiency anemia is also more common in children in the same age bracket. The prevalence of febrile convulsions is 2-5% of the total number of children. Studies discussing the association of iron deficiency anemia and febrile convulsions are contradictory. Management of cases is of great importance as there are special guidelines. Prevention is also vital as it plays a role in evading the occurrence of the convulsions.

scholarly journals Iron Deficiency Anemia as a Risk Factor for First Febrile Seizures a Case Control Study

2020 ◽  
Vol 8 (4) ◽  
pp. 24-29
Author(s):  
V. Ramgopal Rao ◽  
P. Anil Kumar
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Deficiency Anaemia ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Trigger Factor ◽  
Deficiency Anemia ◽  
First Episode ◽  
Deficiency Anaemia

Background: Febrile seizures in children are a common problem. Iron deficiency anaemia is known, among other contributing factors, to be an aggravating factor in febrile seizures. Iron deficiency anaemia is a condition that can be avoided and managed. The study goal was to identify iron deficiency anaemia as a trigger factor for febrile seizures (FS). To determine the association between Iron Deficiency Anemia (IDA) and the first episode of febrile seizures (FFS). Subjects and Methods: Investigation like hemoglobin, blood indices (MCV, MCH), and serum iron and serum ferritin are done for detection of iron deficiency anaemia and their relationship with the first episode of febrile seizure was observed. Results: In our study comprising 50 cases and 50 controls, 58% (29) of cases were diagnosed as IDA with FS, 18% (9) of controls were diagnosed as IDA with Febrile Illness (FI). This suggests IDA as a risk factor for febrile seizures with a significant P value of <0.001. Among 50 cases 42% (21) cases have FS without IDA and among 50 controls 82% (41) controls have FI without IDA were present in the current study. Conclusion: IDA was more common in children with FS than in those with febrile illness (FI) disease alone. The result suggests that the IDA can be a contributing factor to the FFS. Screening of IDA of children with FFS should be regarded. Fever can worsen the negative effects of anaemia or iron deficiency on the brain, which can lead to seizures.

scholarly journals The association between iron deficiency anemia and febrile seizures

2021 ◽  
Vol 8 (2) ◽  
pp. 314
Author(s):  
Mallikarjun Kalmani ◽  
. Basavaraj ◽  
Hareesh Sanikam ◽  
Pushpalatha K. ◽  
Uday Kumar S.
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Cns Infection ◽  
Control Group ◽  
P Value ◽  
Female Ratio ◽  
Male Predominance

Background: Febrile seizures are seizures that occur in children between  6 months and 60 months of age , with body temperature of 38ºC or higher not resulting from Central Nervous System (CNS) infection or any metabolic imbalance without any prior afebrile seizures. Among many risk factors identified for febrile seizures, iron deficiency is hypothesized to be one of the risk factor for occurrence of febrile seizures.Methods: A total of 100 children aged between 6 months to 5 years were included in the present study and were  further divided into 2 groups of 50 each, as cases and controls. Control group consisted of age and gender matched children admitted with acute febrile illness without seizures. A detailed history was taken and clinical examination was done in both cases and controls with particular attention to development delay and family history of seizure. Complete haemogram, iron profile and other appropriate investigations were done in both the groups and results were compared.Results: The mean age of onset of febrile seizures was 32 months. There was slightly male predominance, with male: female ratio of 1.27:1. Majority of children with febrile seizures were found to have iron deficiency anemia as opposed to children in control group which was statistically significant. (76% vs 28%), p-value<0.001. All the indices of iron deficiency anemia, like haemoglobin, MCV, MCH, serum iron, serum ferritin were low in febrile seizures group compared to control group. The difference was found to be statistically significant (p-value<0.001).Conclusions: Iron deficiency anemia (IDA) was more frequent among children with febrile seizures. The result suggests that IDA may be a risk factor for febrile seizures. Early detection and timely correction of iron deficiency may be of help for prevention of recurrence of febrile seizures in children of this age group.

scholarly journals Study of Role of Iron Deficiency Anaemia in Febrile Seizures in Children in a Tertiary Care Centre

2016 ◽  
Vol 35 (2) ◽  
pp. 148-151
Author(s):  
Bheema Naik Sreenivasa ◽  
Gowripura Visweswaraiah Kumar ◽  
Bheema Naik Manjunatha
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
Deficiency Anaemia ◽  
The Mean

Introduction: The world health organization estimates that anaemia largely caused by iron deficiency, affecting between 500 million and two billion people worldwide. Considering the age prevalence of iron deficiency anaemia and febrile convulsion which are the same, the role of iron in the metabolism of neurotransmitter and some enzymes, the function of hemoglobin in conveying oxygen to the brain and since fever can exacerbate symptoms that result from anaemia, a relationship between iron deficiency anaemia and febrile convulsions is probable. Some studies have suggested iron deficiency as a predisposing factor for febrile seizures. We designed this case control study to evaluate the relationship between iron deficiency anaemia and febrile convulsions. The objective of this study was to study the role of iron deficiency as a risk factor for febrile seizures.Materials and Methods: Hundred cases and 100 controls were included in the study. Cases were children of age group six months to six years presenting with febrile seizures. Controls were children of same age group presenting with febrile illness but without any seizures. After informed consent, detailed history was taken and clinical examination done in both cases and controls and blood investigations were done to diagnose iron deficiency anemia. Two groups were matched for age and sex. In all children hemoglobin (Hb) level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW) and plasma ferritin (PF) were determined and the data collected were analyzed statistically.Results: The mean PF was significantly lower in cases compared to controls (p=0.000) and RDW was significantly higher in cases compared to controls (p=0.00). The mean Hb%, MCV, MCH are lower in cases compared to controls but it was statistically not significant.Concluson: Iron deficiency is a significant risk factor for febrile seizures in children of age group six months to six years. Early detection and timely correction of iron deficiency may be helpful for prevention of febrile seizures in children.J Nepal Paediatr Soc 2015;35(2):148-151

scholarly journals Prevalence and causes of iron deficiency anemias in infants aged 9 to 12 months in Estonia

Medicina ◽  
2007 ◽  
Vol 43 (12) ◽  
pp. 947 ◽  
Author(s):  
Neve Vendt ◽  
Heli Grünberg ◽  
Sirje Leedo ◽  
Vallo Tillmann ◽  
Tiina Talvik
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Mean Corpuscular Volume ◽  
Ferritin Level ◽  
Solid Food ◽  
Deficiency Anemia ◽  
Corpuscular Volume ◽  
Main Risk Factor ◽  
Ferritin Concentration

Objective. To investigate the prevalence and causes of iron deficiency anemia in infants aged 9 to 12 months in Estonia. Material and methods. Every second child aged 9–12 months was randomly selected from primary medical centers in seven counties from all over Estonia. A questionnaire concerning eating habits and lifestyle was sent to their parents. Sixty-five percent (n=195) of contacted families agreed to participate in the study. Mean corpuscular volume and hemoglobin, serum ferritin, and soluble transferrin receptor levels were measured in 171 infants. Anemia was defined when hemoglobin level was lower than 105 g/L, and iron deficiency when ferritin level and mean corpuscular volume were lower than 12 µg/L and 74 fL, respectively. Results. The prevalence of iron deficiency was 14.0% and iron deficiency anemia 9.4%. Birthweight less than 3000 g was the main risk factor for iron deficiency (OR=9.4; P<0.0005). Infants fed with breast milk and solid food had lower ferritin concentration (18.5 µg/L, 95% CI 14.0–23.0) than infants fed with formula and solid food (32.8 µg/L, 95% CI 26.6–39) (P<0.005). Conclusion. Iron deficiency anemia is common among 9–12-month-old Estonian infants. The main risk factor for iron deficiency was birthweight less than 3000 g.

Iron deficiency anemia is a risk factor for placental insufficiency and perinatal complications

2016 ◽  
Vol 12_2016 ◽  
pp. 125-130 ◽  
Author(s):  
Radzinsky V.E. Radzinsky ◽  
Ordiyants I.M. Ordiyants ◽  
Pobedinskaya O.S. Pobedinskaya ◽  
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Placental Insufficiency ◽  
Deficiency Anemia ◽  
Perinatal Complications

scholarly journals Incidence of iron deficiency anemia among the children with febrile seizures.

2021 ◽  
Vol 29 (01) ◽  
pp. 121-125
Author(s):  
Samina Batool ◽  
Nadia Qamar ◽  
Akasha Islam ◽  
Saman Jamal ◽  
Qurat-ul-Ain Rana
Keyword(s):  
Socioeconomic Status ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Rural Areas ◽  
Ferritin Level ◽  
Demographic Data ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Duration Of Symptoms

Objective: To determine frequency of iron deficiency anemia among the children having febrile seizures. Study Design: Descriptive Cross Sectional study. Setting: Pediatric Unit Allama Iqbal Memorial Teaching Hospital Sialkot. Period: September 2020 to February 2021. Material & Methods: Total 70 children were studied with age six months to 10 years with either gender presenting with febrile seizures. All data of the patients was documented including demographic data like age, gender, residential area, educational status, socioeconomic status and clinical findings at the time of presentation like fever, fits and duration of symptoms etc. Blood hemoglobin and ferritin level were tested of each patient to evaluate iron deficiency anemia. Results: There were 65.7% male and 34.3% female cases in this study. Age range of the patients was 6 months to 10 years with mean age of 4.36 ± 2.71 years. Most of the children (60%) were below three years of age. Mostly children belonged to low and middle socioeconomic status with the frequency of 42.8% and 45.7% respectively. Iron deficiency anemia was found in 38.6% cases. Majority of the mothers were illiterate (65%). There were 44.3% cases from rural areas and 55.7% from urban area. Conclusion:  Iron deficiency anemia is a common problem among children with febrile seizures, younger than 03 years and belonging to rural areas. Illiterate mothers, is an important risk factor of iron deficiency anemia in their children.

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