scholarly journals Chapter 7. Mechanisms of antinoceptive response of a sensory neuron

2019 ◽  
pp. 132-175
Author(s):  
Olga E. Dik ◽  
◽  
Alexander D. Nozdrachev ◽  
Keyword(s):  
Molecular Mechanism ◽  
Impulse Activity ◽  
Opioid Analgesic ◽  
Temporal Organization ◽  
Stationary States ◽  
Dynamic Complexity ◽  
Nociceptive Neurons ◽  
Pharmacological Targets ◽  
Activation Gating

The seventh chapter is devoted to the determination of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptors. As a result of the study of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptive neurons when the antinociceptive response occurs, it was found that the change in this complexity is based on rearrangements in the temporal organization of patterns due to bifurcations of stationary states and limit cycles, leading to the appearance of two types of burst activity. The mechanism of correction of the damaging pain effect is based on the molecular mechanism of suppression of this activity associated with the modification of the activation gating structure of slow sodium NaV1.8 channels under the action of comenic acid, a drug substance of the non-opioid analgesic “Anoceptin”. The methodology for analyzing the considered molecular mechanism can be used in the search for new pharmacological targets for further research related to the development of innovative pharmacological strategies in the correction of pathological conditions.

Determination of catastrophic sets of a tubular chemical reactor by two-parameter continuation method

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Marek Berezowski
Keyword(s):  
Continuation Method ◽  
Extreme Points ◽  
Chemical Reactor ◽  
Stationary States ◽  
Parameter Continuation Method ◽  
It Systems ◽  
Parametric Continuation ◽  
Parameter Continuation ◽  
Two Parameter

AbstractThe work relates to development and presentation a two-parameter continuation method for determining catastrophic sets of stationary states of a tubular chemical reactor with mass recycle. The catastrophic set is a set of extreme points occurring in the bifurcation diagrams of the reactor. There are many large IT systems that use the parametric continuation method. The most popular is AUTO’97. However, its use is sometimes not convenient. The method developed in this work allows to eliminate the necessity to use huge IT systems from the calculations. Unlike these systems, it can be inserted into the program as a short subroutine. In addition, this method eliminates time-consuming iterations from the calculations.

Determination of morphine and its metabolites in the biological samples: an updated review

Bioanalysis ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 1161-1194
Author(s):  
Roghayeh Amini ◽  
Elaheh Rahimpour ◽  
Abolghasem Jouyban
Keyword(s):  
Analytical Method ◽  
Biological Samples ◽  
Opioid Analgesic ◽  
Individual Variability ◽  
Active Metabolites ◽  
Analytical Research ◽  
Reliable Analytical Method ◽  
Selection Of

Morphine (MO) as an opioid analgesic is used for the treatment of moderate-to-severe pains, particularly cancer-related pains. Pharmacologic studies on MO are complicated due to drugs binding to the protein or metabolization to active metabolites, and even inter-individual variability. This necessitates the selection of a reliable analytical method for monitoring MO and the concentrations of its metabolites in the biological samples for the pharmacokinetic or pharmacodynamic investigations. Therefore, this study was conducted to review all the analytical research carried out on MO and its metabolites in the biological samples during 2007–2019 as an update to the study by Bosch et al. (2007).

Determination of synergy between sulbactam, meropenem and colistin in carbapenem-resistantKlebsiella pneumoniaeandAcinetobacter baumanniiisolates and correlation with the molecular mechanism of resistance

2016 ◽  
Vol 28 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Shakti Laishram ◽  
Shalini Anandan ◽  
Bakthavatchalam Yamuna Devi ◽  
Munusamy Elakkiya ◽  
Babu Priyanka ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Resistance

Variational and Finite Element Analysis of Vibroequilibria

2004 ◽  
Vol 4 (3) ◽  
pp. 290-323 ◽  
Author(s):  
K. Beyer ◽  
M. Günther ◽  
K. Timokha
Keyword(s):  
Finite Element ◽  
Shape Design ◽  
Stationary States ◽  
Optimal Shape Design ◽  
Free Boundaries ◽  
Element Analysis ◽  
Finite Element Approximations ◽  
Potential Flows ◽  
2D And 3D

AbstractWe adapt, via asymptotic expansion, Kapitsa's formula for the effective potential of a pendulum with vibrating suspension to rapidly forced potential flows with free boundaries. Determination of time-averaged stationary states leads to an optimal shape design problem. Under periodic boundary conditions existence and uniqueness of smooth minimizers to the averaged energy is proved using local coerciveness. In the numerical part of the article, 2D and 3D finite element approximations including related error estimates are discussed. Some illustrating examples are sketched.

Crystal Structure Determination of N-(para-Chlorophenyl) Phthalimide and Analysis of its Formation from N-(para-Chlorophenyl) Phthalanilic Acid

1974 ◽  
Vol 29 (11-12) ◽  
pp. 769-779 ◽  
Author(s):  
B. L. Farmer ◽  
J. B. Lando
Keyword(s):  
Crystal Structure ◽  
Molecular Mechanism ◽  
Structure Determination ◽  
Crystalline Phase ◽  
Molecular Motion ◽  
High Energy ◽  
Cyclization Reaction ◽  
Bond Rotation ◽  
A Minor

Crystalline N-(para-chlorophenyl) phthalanilic acid undergoes a topochemical cyclization reaction with the elimination of water yielding crystalline N-(para-chlorophenyl) phthalimide. The crystal structure of the imide product has been determined and compared to the previously determined structure of the reactant. The reaction from this particular crystalline phase of N-(para-chlorophenyl) phthalanilic acid is enhanced by the presence of a high energy molecular conformer of the acid, little molecular motion necessary for reaction, and only a minor rearrangement required to pack into the imide structure after the reaction. A detailed molecular mechanism for this reaction is proposed involving some bond rotation, but little movement of the molecule as a whole.

scholarly journals Determination of the molecular mechanism by which macrophages and γδ-T cells contribute to ZOL-induced ONJ

Aging ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 20743-20752
Author(s):  
Xingzhou Qu ◽  
Zhen Wang ◽  
Tian Zhou ◽  
Liancheng Shan
Keyword(s):  
T Cells ◽  
Molecular Mechanism
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