Chapter 9 DNA Masking in Mammalian Chromatin: A Molecular Mechanism for Determination of Cell Type

1970 ◽  
pp. 317-352 ◽  
Author(s):  
J. Paul
Keyword(s):  
Molecular Mechanism ◽  
Cell Type

Non-contact-based determination of membrane permeability to water and dimethyl sulfoxide of cells virtually trapped in a self-induced micro-vortex

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Hsiu-Yang Tseng ◽  
Chiu-Jen Chen ◽  
Zong-Lin Wu ◽  
Yong-Ming Ye ◽  
Guo-Zhen Huang
Keyword(s):  
Cell Membrane ◽  
Dimethyl Sulfoxide ◽  
Membrane Permeability ◽  
Cell Membrane Permeability ◽  
Cell Type ◽  
Cryoprotective Agents ◽  
A Cell

Cell-membrane permeability to water (Lp) and cryoprotective agents (Ps) of a cell type is a crucial cellular information for achieving optimal cryopreservation in the biobanking industry. In this work, a...

scholarly journals Chapter 7. Mechanisms of antinoceptive response of a sensory neuron

2019 ◽  
pp. 132-175
Author(s):  
Olga E. Dik ◽  
◽  
Alexander D. Nozdrachev ◽  
Keyword(s):  
Molecular Mechanism ◽  
Impulse Activity ◽  
Opioid Analgesic ◽  
Temporal Organization ◽  
Stationary States ◽  
Dynamic Complexity ◽  
Nociceptive Neurons ◽  
Pharmacological Targets ◽  
Activation Gating

The seventh chapter is devoted to the determination of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptors. As a result of the study of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptive neurons when the antinociceptive response occurs, it was found that the change in this complexity is based on rearrangements in the temporal organization of patterns due to bifurcations of stationary states and limit cycles, leading to the appearance of two types of burst activity. The mechanism of correction of the damaging pain effect is based on the molecular mechanism of suppression of this activity associated with the modification of the activation gating structure of slow sodium NaV1.8 channels under the action of comenic acid, a drug substance of the non-opioid analgesic “Anoceptin”. The methodology for analyzing the considered molecular mechanism can be used in the search for new pharmacological targets for further research related to the development of innovative pharmacological strategies in the correction of pathological conditions.

Determination of synergy between sulbactam, meropenem and colistin in carbapenem-resistantKlebsiella pneumoniaeandAcinetobacter baumanniiisolates and correlation with the molecular mechanism of resistance

2016 ◽  
Vol 28 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Shakti Laishram ◽  
Shalini Anandan ◽  
Bakthavatchalam Yamuna Devi ◽  
Munusamy Elakkiya ◽  
Babu Priyanka ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Resistance

Crystal Structure Determination of N-(para-Chlorophenyl) Phthalimide and Analysis of its Formation from N-(para-Chlorophenyl) Phthalanilic Acid

1974 ◽  
Vol 29 (11-12) ◽  
pp. 769-779 ◽  
Author(s):  
B. L. Farmer ◽  
J. B. Lando
Keyword(s):  
Crystal Structure ◽  
Molecular Mechanism ◽  
Structure Determination ◽  
Crystalline Phase ◽  
Molecular Motion ◽  
High Energy ◽  
Cyclization Reaction ◽  
Bond Rotation ◽  
A Minor

Crystalline N-(para-chlorophenyl) phthalanilic acid undergoes a topochemical cyclization reaction with the elimination of water yielding crystalline N-(para-chlorophenyl) phthalimide. The crystal structure of the imide product has been determined and compared to the previously determined structure of the reactant. The reaction from this particular crystalline phase of N-(para-chlorophenyl) phthalanilic acid is enhanced by the presence of a high energy molecular conformer of the acid, little molecular motion necessary for reaction, and only a minor rearrangement required to pack into the imide structure after the reaction. A detailed molecular mechanism for this reaction is proposed involving some bond rotation, but little movement of the molecule as a whole.

scholarly journals Determination of the molecular mechanism by which macrophages and γδ-T cells contribute to ZOL-induced ONJ

Aging ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 20743-20752
Author(s):  
Xingzhou Qu ◽  
Zhen Wang ◽  
Tian Zhou ◽  
Liancheng Shan
Keyword(s):  
T Cells ◽  
Molecular Mechanism

scholarly journals Determination of copper metals in leachate using potentiometric method by concentration cells

2018 ◽  
Vol 49 ◽  
pp. 02018
Author(s):  
Suheryanto ◽  
Zainal Fanani ◽  
Dewi Jayanti
Keyword(s):  
Selectivity Coefficient ◽  
Potentiometric Method ◽  
Cell Type ◽  
Copper Metal ◽  
Linear Region ◽  
Average Accuracy ◽  
Leachate Water ◽  
Concentration Cells ◽  
Determination Of Copper

The potentiometric method of cell type concentration is used to analyze the copper metal in leachate. This method is relatively good because it has a correlation coefficient of 0.9997 and linear region in the concentration range 1×10-5 1×10-3 mol L-1. The precision of this potentiometric method is low because the persent of RSD produced is 0.6% with an average accuracy 0f 95.35%. The detection limit (LoD) of the measurable method is 1.085×10-6 mol L-1 with LoQ 1.313×10-6 mol L-1. While the LoD instrument 1.217×10-6 mol L-1 and LoQ 1.560×10-6 mol L-1. In addition, this method is very selective with the selectivity coefficient of -3.7 and it has uncertainty of measurement 9.7×10-7 ± 1.282×10-6 to 9.12×10-5 ± 3.5×10-5. Potentiometric method of cell type of concentration has an optimum condition at pH5 and temperature 30˚C.The conditions of copper in leachate water renged from 9.253×10-5 to 8.696×10-4 mol L-1

scholarly journals A Simple Method to Estimate the Number of Autophagic Elements by Electron Microscopic Morphometry in Real Cellular Dimensions

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Attila L. Kovács
Keyword(s):  
Surface Density ◽  
Average Diameter ◽  
Volume Density ◽  
Cell Type ◽  
Electron Microscopic ◽  
Simple Method ◽  
Density Data ◽  
Pancreatic Cells ◽  
Electron Microscopic Morphometry

Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple and time efficient method is suggested here to use exactly calculated specific surface values and estimate average diameter and number of autophagic elements in real cellular dimensions. The method is based on the easiest morphometric determination of relative surface (surface density) and volume (volume density) data by electron microscopy. A series of data from real experimental samples of liver and exocrine pancreatic cells are offered to illustrate the potential of these measurements and calculations.

scholarly journals The Determination of the Salt Relations of the Cytoplasmic Phase in Cells of Beetroot Tissue

1963 ◽  
Vol 16 (3) ◽  
pp. 647 ◽  
Author(s):  
MG Pitman
Keyword(s):  
Free Space ◽  
Cell Type ◽  
In Cells

An analysis of the rate at which isotope diffuses out of disks of beetroot tissue shows that there are at least two components of the non-free space. As tlwse components are not due to differences in cell type within the tissue, it is suggested they are due to a cytoplasmic phase in the parenchymatou's cells, and to the vacuoles.

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