Pharmacological Interventions for Binge Eating: Lessons from Animal Models, Current Treatments, and Future Directions

2011 ◽  
Vol 17 (12) ◽  
pp. 1180-1187 ◽  
Author(s):  
Laura A. Berner ◽  
Miriam E. Bocarsly ◽  
Bartley G. Hoebel ◽  
Nicole M. Avena
Keyword(s):  
Animal Models ◽  
Binge Eating ◽  
Pharmacological Interventions ◽  
Future Directions

Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

2014 ◽  
Vol 18 (8) ◽  
Author(s):  
Cristina Frange ◽  
Camila Hirotsu ◽  
Helena Hachul ◽  
Paula Araujo ◽  
Sergio Tufik ◽  
...  
Keyword(s):  
Animal Models ◽  
Future Directions ◽  
A Current

Pathologic role of neuronal nicotinic acetylcholine receptors in epileptic disorders: implication for pharmacological interventions

2015 ◽  
Vol 26 (2) ◽  
Author(s):  
Mehdi Ghasemi ◽  
Arash Hadipour-Niktarash
Keyword(s):  
Animal Models ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Neurological Diseases ◽  
Juvenile Myoclonic Epilepsy ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Pharmacological Interventions ◽  
Nicotinic Acetylcholine ◽  
Neuronal Nachr

AbstractAccumulating evidence suggests that neuronal nicotinic acetylcholine receptors (nAChRs) may play a key role in the pathophysiology of some neurological diseases such as epilepsy. Based on genetic studies in patients with epileptic disorders worldwide and animal models of seizure, it has been demonstrated that nAChR activity is altered in some specific types of epilepsy, including autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and juvenile myoclonic epilepsy (JME). Neuronal nAChR antagonists also have antiepileptic effects in pre-clinical studies. There is some evidence that conventional antiepileptic drugs may affect neuronal nAChR function. In this review, we re-examine the evidence for the involvement of nAChRs in the pathophysiology of some epileptic disorders, especially ADNFLE and JME, and provide an overview of nAChR antagonists that have been evaluated in animal models of seizure.

scholarly journals Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans

2014 ◽  
Vol 171 (20) ◽  
pp. 4767-4784 ◽  
Author(s):  
M A van Gestel ◽  
E Kostrzewa ◽  
R A H Adan ◽  
S K Janhunen
Keyword(s):  
Animal Models ◽  
Binge Eating ◽  
Pharmacological Manipulations

Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

Physiology ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 314-326 ◽  
Author(s):  
Alicia D’Souza ◽  
Tariq Trussell ◽  
Gwilym M. Morris ◽  
Halina Dobrzynski ◽  
Mark R. Boyett
Keyword(s):  
Atrial Fibrillation ◽  
Animal Models ◽  
Heart Block ◽  
Research Agenda ◽  
Sinus Bradycardia ◽  
Vagal Tone ◽  
Supporting Evidence ◽  
Supraventricular Arrhythmias ◽  
Future Directions ◽  
New Directions

Athletes are prone to supraventricular rhythm disturbances including sinus bradycardia, heart block, and atrial fibrillation. Mechanistically, this is attributed to high vagal tone and cardiac electrical and structural remodeling. Here, we consider the supporting evidence for these three pro-arrhythmic mechanisms in athletic human cohorts and animal models, featuring current controversies, emerging data, and future directions of relevance to the translational research agenda.

Binge eating disorder: Current state and future directions

1995 ◽  
Vol 15 (8) ◽  
pp. 865-890 ◽  
Author(s):  
Louis G. Castonguay ◽  
Kathleen L. Eldredge ◽  
W.Stewart Agras
Keyword(s):  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Future Directions ◽  
Current State

scholarly journals Exercise, brain, and cognition across the life span

2011 ◽  
Vol 111 (5) ◽  
pp. 1505-1513 ◽  
Author(s):  
Michelle W. Voss ◽  
Lindsay S. Nagamatsu ◽  
Teresa Liu-Ambrose ◽  
Arthur F. Kramer
Keyword(s):  
Resistance Training ◽  
Animal Models ◽  
Life Span ◽  
Current Evidence ◽  
Brain Health ◽  
Future Directions ◽  
Exercise Type ◽  
Clinically Significant ◽  
The Brain ◽  
Human Neuroimaging

This is a brief review of current evidence for the relationships between physical activity and exercise and the brain and cognition throughout the life span in non-pathological populations. We focus on the effects of both aerobic and resistance training and provide a brief overview of potential neurobiological mechanisms derived from non-human animal models. Whereas research has focused primarily on the benefits of aerobic exercise in youth and young adult populations, there is growing evidence that both aerobic and resistance training are important for maintaining cognitive and brain health in old age. Finally, in these contexts, we point out gaps in the literature and future directions that will help advance the field of exercise neuroscience, including more studies that explicitly examine the effect of exercise type and intensity on cognition, the brain, and clinically significant outcomes. There is also a need for human neuroimaging studies to adopt a more unified multi-modal framework and for greater interaction between human and animal models of exercise effects on brain and cognition across the life span.

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