Microwave Assisted Organic Synthesis: Cross Coupling and Multicomponent Reactions

Conventionally, the organic reactions are accomplished by conductive heating with an external heat source like an oil bath. On the contrary, since its inception, the application of microwave irradiation is growing as a suitable alternate heating method in organic synthesis. Microwave heating considerably reduces the reaction time without promoting any side reactions. The fundamental synthetic organic chemistry majorly deals with transition-metal-catalyzed C–C and C–heteroatom bond formation reactions. It is one of the most important methods in contemporary chemistry resulting in a tremendous increment in the applications of these reactions during the last few years. This field has been acknowledged with a number of Nobel Prizes during the last decade (2001, 2005 and 2010). A considerable effort has been done on the continuous development of new ligands and catalysts as well as an increased understanding of the mechanisms for the improvement of the reaction condition. This review focuses on some of the latest developments in the area of cross-coupling reactions aided by microwave irradiation.

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Multicomponent Reactions to Form Heterocycles by Microwave-Assisted Continuous Flow Organic Synthesis.

ChemInform ◽

10.1002/chin.200720034 ◽

2007 ◽

Vol 38 (20) ◽

Author(s):

W. Stacy Bremner ◽

Michael G. Organ

Keyword(s):

Organic Synthesis ◽

Continuous Flow ◽

Multicomponent Reactions ◽

Microwave Assisted

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Multicomponent Reactions to Form Heterocycles by Microwave-Assisted Continuous Flow Organic Synthesis

Journal of Combinatorial Chemistry ◽

10.1021/cc060130p ◽

2007 ◽

Vol 9 (1) ◽

pp. 14-16 ◽

Cited By ~ 88

Author(s):

W. Stacy Bremner ◽

Michael G. Organ

Keyword(s):

Organic Synthesis ◽

Continuous Flow ◽

Multicomponent Reactions ◽

Microwave Assisted

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Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides

Journal of the American Chemical Society ◽

10.1021/jacs.1c00906 ◽

2021 ◽

Author(s):

Tamae Seo ◽

Naoki Toyoshima ◽

Koji Kubota ◽

Hajime Ito

Keyword(s):

Solid State ◽

Organic Synthesis ◽

Cross Coupling ◽

Aryl Halides

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Recent Advances in C–Br Bond Formation

Synlett ◽

10.1055/s-0037-1610772 ◽

2021 ◽

Author(s):

Ying-Yeung Yeung ◽

Jonathan Wong

Keyword(s):

Organic Synthesis ◽

Aromatic Compounds ◽

Bond Formation ◽

Cross Coupling ◽

Catalytic Site ◽

Atom Transfer ◽

Bond Forming ◽

Recent Advances ◽

Catalytic Asymmetric ◽

Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

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Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods

Chemistry Proceedings ◽

10.3390/ecsoc-24-08380 ◽

2020 ◽

Vol 3 (1) ◽

pp. 57

Author(s):

Luka Barešić ◽

Davor Margetić ◽

Zoran Glasovac

Keyword(s):

High Pressure ◽

Functional Groups ◽

Organic Synthesis ◽

High Speed ◽

Environmentally Friendly ◽

Microwave Assisted ◽

Pressure Synthesis ◽

Ultrasound Assisted ◽

Substituted Furans ◽

Guanidine Moiety

The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.

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