Antioxidant, Xanthine Oxidase and Monoamine Oxidase Inhibitory Potential of Coumarins: A Review

: For the last two decades, there has been research interest on the design of molecules possessing dual inhibitory potential on cholinesterase and monoamine oxidase enzymes, particularly for the treatment of two major neurodegenerative diseases, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Many compounds have been synthesized for this purpose, and some of them have been shown to display activities comparable or superior to the activities of current drugs used for the treatment of AD and PD. Within the concept of this review study, we have aimed to present the current drugs used for the treatment of AD and PD, their mechanism of action, the discussion behind the theory of designing dual inhibitor agents, and the presentation of the most active compounds with diverse heterocyclic scaffolds displayed in research studies published in the recent period.

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EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY BY FLAVONOIDS FROM PONGAMIA PINNATA LINN

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i3.16303 ◽

2017 ◽

Vol 10 (3) ◽

pp. 360 ◽

Cited By ~ 1

Author(s):

Vanishree Bambrana ◽

Dayanand Cd ◽

Sheela Sr

Keyword(s):

Xanthine Oxidase ◽

Plant Extracts ◽

Inhibitory Activity ◽

Mangifera Indica ◽

Zingiber Officinale ◽

Pongamia Pinnata ◽

Morinda Citrifolia ◽

Dried Fruit ◽

Fruit Powder ◽

Inhibitory Potential

ABSTRACTObjective: Flavonoids from the crude seeds extract of Pongamia pinnata L., dried fruit powder of Morinda citrifolia L., bark of Mangifera indica L., andrhizome of Zingiber officinale Rosc. were screened for xanthine oxidase (XO) inhibition at different concentration. The inhibitory potential of quercetinand allopurinol were used for the determination of 50% inhibitory concentration (IC50) and Ki values.Methods: Isolation of flavonoids from the plant extracts was processed by column chromatography and tested for XO inhibitory activity in the rangeof 6-800 μg/ml.Results: The results demonstrated that optimized flavonoids extract of P. pinnata L. exhibited promising XO inhibition. P. pinnata L., M. indica L., andZ. officinale Rosc. had IC50 in the concentration of 8.74 mM, 1.09 mM, 5.4 mM and Ki 0.35 mM, 1.73 mM, 2.7 mM, respectively.Conclusion: The study showed that plant species under investigation exhibited XO inhibition by optimized flavonoid extract. P. pinnata L. indicatedpromising XO inhibition compared to other plant extracts. Flavonoids can be used as a potent inhibitor of XO an alternative to allopurinol.Keywords: Xanthine oxidase, Quercetin, Allopurinol, Pongamia pinnata, Oxidative stress.

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Effect of Polymerization on Antioxidant and Xanthine Oxidase Inhibitory Potential of Sea Buckthorn (H. rhamnoides) Proanthocyanidins

Journal of Food Science ◽

10.1111/j.1750-3841.2012.02884.x ◽

2012 ◽

Vol 77 (10) ◽

pp. C1036-C1041 ◽

Cited By ~ 21

Author(s):

Ranjith Arimboor ◽

C. Arumughan

Keyword(s):

Xanthine Oxidase ◽

Sea Buckthorn ◽

Inhibitory Potential

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Evaluation of Antioxidant and Xanthine Oxidase Inhibitory Potential of Methanolic Leaf Extract of Stevia rebaudiana

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i59b34384 ◽

2021 ◽

pp. 302-309

Author(s):

M. Rishikesan ◽

R. Gayathri ◽

V. Vishnu Priya ◽

J. Selvaraj ◽

S. Kavitha

Keyword(s):

Uric Acid ◽

Xanthine Oxidase ◽

Leaf Extract ◽

Statistical Significance ◽

Stevia Rebaudiana ◽

Dependent Manner ◽

Percolation Method ◽

Inhibitory Potential ◽

Dose Dependent ◽

Range Test

Background: Stevia rebaudiana is a shrub-like plant that belongs to the sunflower family and is commonly referred as stevia.It is 1000 times sweeter than sugar even at a very low concentration. Xanthine oxidase is an enzyme that generates oxygen species and catalyzes the production of uric acid from purine metabolism.Overproduction of uric acid results in a clinical condition called gout. The aim of this study is to explore the phytochemicals, antioxidant and xanthine oxidase inhibitory potential of methanolic leaf extract of stevia rebaudiana. Methods: Methanolic leaf extract of Stevia rebaudiana was prepared by the Hot Percolation method. Phytochemical screening was done to analyse the presence of various phytochemicals. The leaf extract was tested for its antioxidant and xanthine oxidase inhibitory potentials. The data were analyzed statistically by a one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant. Results: It was observed that the methanolic leaf extract of Stevia rebaudiana has significant antioxidant potential (Ic50 of = 310 μg/ml) as well as xanthine oxidase inhibitory potentials(Ic50 of = 270 μg/ml) and the activity increased in a dose dependent manner as compared to that of standard (Vitamin C and Allopurinol respectively). Conclusion: The study proves the antioxidant and xanthine oxidase inhibitory efficacy of Stevia rebaudiana and throws light on the prospects of drug formation against oxidant activity and gout formation.

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