Ionic Liquids for the Synthesis of Five-Membered N,N-, N,N,N- and N,N,N,NHeterocycles

2019 ◽  
Vol 23 (11) ◽  
pp. 1214-1238 ◽  
Author(s):  
Navjeet Kaur ◽  
Pranshu Bhardwaj ◽  
Meenu Devi ◽  
Yamini Verma ◽  
Neha Ahlawat ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Reaction Medium ◽  
Environmental Issues ◽  
Organic Reaction ◽  
Environment Friendly ◽  
The Past ◽  
Area Of Interest ◽  
Major Subject

Due to special properties of ILs (Ionic Liquids) like their wide liquid range, good solvating ability, negligible vapour pressure, non-inflammability, environment friendly medium, high thermal stability, easy recycling and rate promoters etc. they are used in organic synthesis. The investigation for the replacement of organic solvents in organic synthesis is a growing area of interest due to increasing environmental issues. Therefore, ionic liquids have attracted the attention of chemists and act as a catalyst and reaction medium in organic reaction with high activity. There is no doubt that ionic liquids have become a major subject of study for modern chemistry. In comparison to traditional processes the use of ionic liquids resulted in improved, complimentary or alternative selectivities in organic synthesis. The present manuscript reported the synthesis of multiple nitrogen containing five-membered heterocyclic compounds using ionic liquids. This review covered interesting discoveries in the past few years.

Ionic Liquids: A Versatile Medium for the Synthesis of Six-membered Two Nitrogen- Containing Heterocycles

2019 ◽  
Vol 23 (1) ◽  
pp. 76-96 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Thermal Stability ◽  
Ionic Liquids ◽  
High Activity ◽  
Organic Synthesis ◽  
Vapour Pressure ◽  
Reaction Medium ◽  
High Thermal Stability ◽  
Organic Reaction ◽  
Major Subject ◽  
The Subject

Due to special properties of ILs (ionic liquids) like their wide liquid range, good solvating ability, negligible vapour pressure, non-inflammability, environmentfriendly medium, high thermal stability, easy recycling and rate promoters etc. they are used in organic synthesis. Therefore, ionic liquids have attracted the attention of chemists and act as a catalyst and reaction medium in organic reaction with high activity. There is no doubt that ionic liquids have become a major subject of study for modern chemistry. More publications in the field have been observed each year, although there is some evidence that this is beginning to plateau at approximately 3500 papers each year. They have been the subject of several major reviews and books, dealing with different applications and aspects of their behavior. Highly efficient methods are explored for the preparation of six-membered two nitrogen-containing heterocycles with the application of IL as a catalyst and reaction medium from 1893 to 2018.

Task-specific Ionic Liquids as a Green Catalysts and Solvents for Organic Synthesis

2020 ◽  
Vol 7 (1) ◽  
pp. 105-119 ◽  
Author(s):  
Swapnil A. Padvi ◽  
Dipak S. Dalal
Keyword(s):  
Ionic Liquids ◽  
Physical Properties ◽  
Organic Synthesis ◽  
Review Article ◽  
Present Review ◽  
Organic Transformations ◽  
The Past ◽  
Properties Characterization

Task-specific ionic liquids (TSILs) have received increased attention over the past few years as a Green Catalysts and Solvents for a large number of organic transformations. The present review article aims to provide an introduction, types of task-specific ionic liquids, preparation/synthesis, physical properties, characterization, use of TSILs as solvent and catalyst in organic synthesis.

Naturally derived sugar-based ionic liquids: an emerging tool for sustainable organic synthesis and chiral recognition

2021 ◽  
Author(s):  
Sabbasani Rajasekhara Reddy ◽  
Priyanka Muthukuru ◽  
P. Krisnaraj ◽  
Jayachandra Rayadurgam
Keyword(s):  
Ionic Liquids ◽  
Organic Synthesis ◽  
Chiral Recognition ◽  
Natural Abundance ◽  
Promising Candidate ◽  
The Past

During the past decade, the synthesis of sugar-based ionic liquids (SILs) from natural sugars has been described as a promising candidate. This is due to their natural abundance in large...

Illuminating a Path for Organic Synthesis Towards Sustainability. No One Said It Would Be Easy…

Synlett ◽  
2021 ◽  
Author(s):  
Bruce H. Lipshutz
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Reaction Medium ◽  
Base Metals ◽  
Bottom Line ◽  
Reactive Metal ◽  
Metal Chemistry ◽  
The Past ◽  
Environmentally Responsible ◽  
Petroleum Reserves

AbstractA personalized account is presented describing some of the stories behind the scenes in efforts to convert organic chemistry into a more sustainable discipline. These are part of a group ‘crusade’ started almost 15 years ago aimed at providing technologies illustrative of how key reactions used today can be ‘faster, better, cheaper’ when run in recyclable water. Hence, the option now exists to do organic synthesis in a far more environmentally responsible fashion. By contrast, most of organic chemistry developed over the past 200 years that relies on organic solvents continues to generate enormous amounts of pollution, while depleting finite petroleum reserves and our supplies of many precious and base metals. Making the switch to water, Nature’s chosen reaction medium, akin to that in which bio-catalysis is typically performed, is inevitable.1 The Story Begins: A Different Type of Prejudice2 Are We up to the Challenge? Too Late Now…3 ‘Impossible’ Reactive Metal Chemistry in Water4 Didn’t I Once Say: ‘It’s All about the Ligand’?5 What Happens When Our Supply of Palladium Runs Out?6 What Are the Implications from These Tales for Today and Tomorrow?7 What Is the ‘Broader Impact’ of This Work?8 The Bottom Line…

scholarly journals Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7523
Author(s):  
Helen A. Goulart ◽  
Daniela R. Araujo ◽  
Filipe Penteado ◽  
Raquel G. Jacob ◽  
Gelson Perin ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Environmentally Friendly ◽  
The Past ◽  
Recent Advances ◽  
Inorganic Species ◽  
Species Being ◽  
Potassium Peroxymonosulfate

Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become becoming a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations.

Microwave: A Green Contrivance for the Synthesis of N-Heterocyclic Compounds

2020 ◽  
Vol 24 (22) ◽  
pp. 2527-2554
Author(s):  
Trimurti L. Lambat ◽  
Paavan Kavi Param Gaitry Chopra ◽  
Sami H. Mahmood
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Microwave Energy ◽  
Catalytic Reactions ◽  
Polymer Chemistry ◽  
Microwave Chemistry ◽  
Dielectric Heating ◽  
Biochemical Processes ◽  
The Past ◽  
Material Sciences

Microwave Mediated Organic Synthesis (MMOS) is typical on the proficient heat shift carried out by dielectric heating, which in turn, is primarily dependent on the capability of the reagent or solvent to take up microwave energy. The employment of microwave energy has witnessed a fast expansion in the past two decades, with novel and pioneering applications in peptide and organic synthesis, material sciences, polymer chemistry, biochemical processes and nanotechnology. This review summarizes current MW- mediated catalytic reactions in use for the synthesis of a diversity of N-heterocycles by Multi- Component Reactions (MCRs) and a variety of miscellaneous reactions. In addition, the review addresses some aspects of the use of nanoparticles for a diversity of applications in microwave chemistry.

scholarly journals Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds

2019 ◽  
Vol 31 (12) ◽  
pp. 2698-2706
Author(s):  
Khushbu Gupta ◽  
Tejpal Singh Chundawat
Keyword(s):  
Metabolic Engineering ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Process Conditions ◽  
Biogenic Synthesis ◽  
The Past ◽  
Green Route ◽  
Clean Manufacturing ◽  
Synthetic Application

Green route of biogenic synthesis of heterocyclic compounds via microbes (bacteria, fungi, virus, yeast, algae, etc.) has the potential to deliver clean manufacturing technology. The application of biocatalysts for the synthesis of novel compounds has attracted increasing attention over the past few years and consequently, high demands have been placed on the identification of new biocatalysts for organic synthesis. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies. The characteristics of biocatalyst can be tailored with protein engineering and metabolic engineering methods to meet the desired process conditions. This review discusses the synthetic application of all the six classes of enzymes which are oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase. Enzymes are highly selective catalysts and their contribution to regio-, chemo- and stereoselectivity of compounds were also discussed.

Eco-Friendly Synthesis of Pyrazoline Derivatives

2017 ◽  
Vol 9 (04) ◽  
Author(s):  
Mahesh G. Kharatmol ◽  
Deepali Jagdale
Keyword(s):  
Ionic Liquids ◽  
Microwave Irradiation ◽  
Organic Synthesis ◽  
Ultrasonic Irradiation ◽  
Minimal Energy ◽  
Anticancer Activities ◽  
Conventional Methods

Pyrazoline class of compounds serve as better moieties for an array of treatments, they have antibacterial, antifungal, antiinflammatory, antipyretic, diuretic, cardiovascular activities. Apart from these they also have anticancer activities. So, pertaining to its importance, many attempts are made to synthesize pyrazolines. Since conventional methods of organic synthesis are energy and time consuming. There are elaborate pathways for green and eco-friendly synthesis of pyrazoline derivatives including microwave irradiation, ultrasonic irradiation, grinding and use of ionic liquids which assures the synthesis of the same within much lesser time and by use of minimal energy

Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present

2020 ◽  
Vol 20 (10) ◽  
pp. 908-920 ◽  
Author(s):  
Su-Min Wu ◽  
Xiao-Yang Qiu ◽  
Shu-Juan Liu ◽  
Juan Sun
Keyword(s):  
Monoamine Oxidase ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
The Past ◽  
Structure Activity ◽  
Receptor Interactions ◽  
Heterocyclic Derivatives ◽  
Inhibitory Activities ◽  
Leading Compounds ◽  
Heterocyclic Moiety

Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neurodegenerative diseases such as depression, Parkinson’s disease and Alzheimer’s disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single heterocyclic derivatives with MAO inhibitory activities during the past decade. This review covers recent pharmacological advancements of single heterocyclic moiety along with structure- activity relationship to provide better correlation among different structures and their receptor interactions.

Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles

2019 ◽  
Vol 16 (2) ◽  
pp. 258-275 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Synthesis ◽  
Biological Activities ◽  
Reaction Times ◽  
Research Field ◽  
Environmentally Benign ◽  
Metal Catalyst ◽  
Efficient Synthesis ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Harsh Conditions

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

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