Synthesis of Heterocyclic Compounds through Multicomponent Reactions using 6-Aminouracil as starting reagent

2021 ◽  
Vol 25 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Marzieh Rad ◽  
Fatemeh Mohajer ◽  
Hitesh Sehrawat ◽  
Ravi Tomar
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Essential Components

: The analogs of 6-Amino uracil are essential components due to their biological activity. The uracil is used as an important component for the synthesis of heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, the application of this compound is reviewed as a precursor in the synthesis of many heterocyclic cores from 2016 to 2020.

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Isoselenocyanates: Synthesis and Their Use for Preparing Selenium-Based Heterocycles

Synthesis ◽  
2021 ◽  
Author(s):  
Stefan H. Bossmann ◽  
Raul Neri
Keyword(s):  
Biological Activity ◽  
Infectious Diseases ◽  
Cancer Cells ◽  
Multicomponent Reactions ◽  
Oxidative Cyclization ◽  
Biologically Active ◽  
Organoselenium Compounds ◽  
X Ray ◽  
Synthetic Work

AbstractIsoselenocyanates (ISCs) are a class of organoselenium compounds that have been recognized as potential chemotherapeutic and chemopreventative agents against cancer(s) and infectious diseases. ISC compounds are chemically analogous to their isosteric relatives, isothiocyanates (ITCs); however, they possess increased biological activity, such as enhanced cytotoxicity against cancer cells. ISCs not only serve as significant products, but also as precursors and essential intermediates for a variety of organoselenium compounds, such as selenium-containing heterocycles, which are biologically active. While syntheses of ISCs have become less difficult to accomplish, the syntheses of selenium-containing heterocycles are often difficult due to the use of highly toxic selenium reagents. Because of this, ISCs can serve as versatile reagents for the preparation of these heterocycles. In this review, the classical and recent syntheses of ISCs will be discussed, along with notable and recent synthetic work employing ISCs to access novel selenium-containing heterocycles.1 Introduction1.1 Selenium and Health2 Isoselenocyanates2.1 Preparation of Isoselenocyanates3 Selenium-Containing Heterocycles3.1 Notable Synthetic Work3.2 Recent Synthetic Work3.2.1 Synthesis of N-(3-Methyl-4-phenyl-3H-selenazol-2-ylidene)benzamide­ Derivatives3.2.2 Synthesis and X-ray Studies of Diverse Selenourea Derivatives3.2.3 Synthesis of Heteroarene-Fused [1,2,4]Thiadiazoles/Selenadiazoles via Iodine-Promoted [3+2] Oxidative Cyclization3.2.4 2-Amino-1,3-selenazole Derivatives via Base-Promoted Multicomponent Reactions4 Conclusion

1,2,3-Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3-Dipolar Cycloadditions

2014 ◽  
Vol 2014 (16) ◽  
pp. 3289-3306 ◽  
Author(s):  
Antonino Lauria ◽  
Riccardo Delisi ◽  
Francesco Mingoia ◽  
Alessio Terenzi ◽  
Annamaria Martorana ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloadditions

scholarly journals Synthesis and study biological activity of new heterocyclic compounds based on sugar

2020 ◽  
Author(s):  
Ehab K. Obaid ◽  
Rahmah H. Abdullah ◽  
Hussein Abdulkadim Hasan ◽  
Najlaa N. Hussein ◽  
Maha A. Khalaf ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds

Scope and Post-Transformations for the Borane-Isocyanide Multicomponent Reactions: Concise Access to Structurally Diverse Heterocyclic Compounds

2013 ◽  
Vol 355 (16) ◽  
pp. 3273-3284 ◽  
Author(s):  
Nicola Kielland ◽  
Esther Vicente-García ◽  
Marc Revés ◽  
Nicolas Isambert ◽  
María José Arévalo ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions

Synthesis and biological activity of some more heterocyclic compounds containing benzothiophene moiety

2011 ◽  
Vol 32 (3) ◽  
pp. 235-247 ◽  
Author(s):  
Gadada Naganagowda ◽  
Patchanita Thamyongkit ◽  
Runchana Klai-U-dom ◽  
Waraporn Ariyakriangkrai ◽  
Arithat Luechai ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds

scholarly journals One pot synthesis of 3, 4-dihydropyrimidine-2(1H)-thiones using orange peel powder under ultrasonic irradiation

2020 ◽  
Vol 9 (1) ◽  
pp. 919-923
Keyword(s):  
Reaction Time ◽  
Ultrasonic Irradiation ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Orange Peel ◽  
Biologically Active ◽  
High Yield ◽  
Atom Economy ◽  
One Pot ◽  
The Past

Biginelli, an important multicomponent reaction provides an avenue for the synthesis of different biologically active heterocyclic compounds. During the past decade, one pot multicomponent reactions have attracted the attention of organic and medicinal chemists due to high atom economy, time and enery saving convergent nature. The present manuscript reports a simple one pot three component synthesis of 3, 4-dihydroprimidin-2(1H)-thiones from various diversely substituted aldehydes, ethyl acetoacetate and thiourea using a orange peel powder as a natural catalyst on ultrasonic irradiation in aqueous medium as the solvent. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature.

The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions

2019 ◽  
Vol 23 (4) ◽  
pp. 1029-1064
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Razieh Moradi ◽  
Tahereh Ahmadi ◽  
Parisa Gholamzadeh
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Molecular Diversity
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