Current Designs and Developments of Fucoidan-based Formulations for Cancer Therapy

2020 ◽  
Vol 20 (12) ◽  
pp. 933-941 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Agent ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Functional Material ◽  
Nanostructure Materials ◽  
Bioactive Properties ◽  
Review Current ◽  
Structure Properties

Background: Natural nanostructure materials have been involved in antitumor drug delivery systems due to their biocompatibility, biodegradation, and bioactive properties. Methods: These materials have contributed to advanced drug delivery systems in the roles of both bioactive compounds and delivery nanocarriers. Fucoidan, a valuable ocean material used in drug delivery systems, has been exploited in research on cancer and a variety of other diseases. Results: Although the uniqueness, structure, properties, and health benefits of fucoidan have been mentioned in various prominent reviews, current developments and designs of fucoidan-based formulations still need to be assessed to further develop an effective anticancer therapy. In this review, current important formulations using fucoidan as a functional material and as an anticancer agent will be discussed. This article will also provide a brief principle of the methods that incorporate functional nanostructure materials in formulations exploiting fucoidan. Conclusion: Current research and future perspectives on the use of fucoidan in anticancer therapy will advance innovative and important products for clinical uses.

Linalool bioactive properties and potential applicability in drug delivery systems

2018 ◽  
Vol 171 ◽  
pp. 566-578 ◽  
Author(s):  
Irina Pereira ◽  
Patrícia Severino ◽  
Ana C. Santos ◽  
Amélia M. Silva ◽  
Eliana B. Souto
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Bioactive Properties ◽  
Potential Applicability

Receptor-Based Combinatorial Nanomedicines

2021 ◽  
pp. 339-355
Author(s):  
Harshita Abul Barkat ◽  
Md Abul Barkat ◽  
Mohamad Taleuzzaman ◽  
Sabya Sachi Das ◽  
Md. Rizwanullah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Multiple Drug ◽  
Conventional Drug ◽  
Drug Regimens

Nanotechnology-based drug-delivery systems, as an anticancer therapy tool, have shown significant potentials for the diagnosis and treatment of cancer. Recent studies have demonstrated that cancer therapy could be efficiently achieved by combinatorial therapies, approaches using multiple drug regimens for targeting cancers. However, their usages have been limited due to shorter half-lives of chemotherapeutic agents, insignificant targetability to tumor sites and suboptimal levels of co-administered conventional drug moieties. Thus, nanotechnology-based drug-delivery systems with effective targetability have played a crucial role to overcome the limitations and challenges associated with conventional therapies and also have provided greater therapeutic efficacy. Herein, the authors have focused on various drug-incorporated combinatorial nanocarrier systems, the significance of various receptors-associated strategies, and various targeted delivery approaches for chemotherapeutic agents.

scholarly journals Niosomes: a review of their structure, properties, methods of preparation, and medical applications

2018 ◽  
Vol 11 (4) ◽  
pp. 301-314 ◽  
Author(s):  
Pei Ling Yeo ◽  
Chooi Ling Lim ◽  
Soi Moi Chye ◽  
Anna Pick Kiong Ling ◽  
Rhun Yian Koh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Nonionic Surfactants ◽  
Serum Proteins ◽  
Pharmaceutical Compounds ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
Structural Components ◽  
Hydrophilic Drugs ◽  
Structure Properties

AbstractTarget-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes’ structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

Supramolecular polymer nanocapsules by enzymatic covalent condensation: biocompatible and biodegradable drug-delivery systems for chemo-photothermal anticancer therapy

2019 ◽  
Vol 10 (26) ◽  
pp. 3566-3570 ◽  
Author(s):  
Shengda Liu ◽  
Zupeng Huang ◽  
Fei Li ◽  
Tengfei Yan ◽  
Shuang Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Supramolecular Polymer ◽  
Biodegradable Drug Delivery Systems

Supramolecular polymer nanocapsules were constructed by enzymatic covalent condensation and they acted as drug-delivery systems for chemo-photothermal anticancer therapy.

scholarly journals Drug delivery systems based on biocompatible imino-chitosan hydrogels for local anticancer therapy

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 1080-1090 ◽  
Author(s):  
Daniela Ailincai ◽  
Liliana Tartau Mititelu ◽  
Luminita Marin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Chitosan Hydrogels

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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