scholarly journals Niosomes: a review of their structure, properties, methods of preparation, and medical applications

2018 ◽  
Vol 11 (4) ◽  
pp. 301-314 ◽  
Author(s):  
Pei Ling Yeo ◽  
Chooi Ling Lim ◽  
Soi Moi Chye ◽  
Anna Pick Kiong Ling ◽  
Rhun Yian Koh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Nonionic Surfactants ◽  
Serum Proteins ◽  
Pharmaceutical Compounds ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
Structural Components ◽  
Hydrophilic Drugs ◽  
Structure Properties

AbstractTarget-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes’ structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

Novel Ciprofloxacin Derivatives for Polymer-Based Drug Delivery Systems

2018 ◽  
Vol 762 ◽  
pp. 36-41
Author(s):  
Tatjana Gerasimova ◽  
Vitālijs Rjabovs ◽  
Māris Turks
Keyword(s):  
Drug Delivery ◽  
Functional Groups ◽  
Drug Delivery Systems ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
Covalent Attachment ◽  
Fluoroquinolone Antibiotic ◽  
Derivatives Of

Novel derivatives of fluoroquinolone antibiotic ciprofloxacin were synthesized. The modifications of both the N- and C-termini were focused on introduction of functionalized linkers that can be used for covalent attachment to natural or synthetic polymers with appropriate functional groups.

scholarly journals Comparison of Polydopamine-Coated Mesoporous Silica Nanorods and Spheres for the Delivery of Hydrophilic and Hydrophobic Anticancer Drugs

2019 ◽  
Vol 20 (14) ◽  
pp. 3408 ◽  
Author(s):  
Anna-Karin Pada ◽  
Diti Desai ◽  
Kaiyao Sun ◽  
Narayana Prakirth Govardhanam ◽  
Kid Törnquist ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Hydrophilic Drugs

Mesoporous silica nanoparticles (MSNs) have been widely studied as drug delivery systems in nanomedicine. Surface coating of MSNs have enabled them to perform efficiently in terms of bioavailability, biocompatibility, therapeutic efficacy and targeting capability. Recent studies have suggested the use of polydopamine (PDA) as a facilitative coating for MSNs that provides sustained and pH-responsive drug release, owing to the adhesive “molecular-glue” function of PDA. This further endows these hybrid MSN@PDA particles with the ability to carry large amounts of hydrophilic drugs. In this study, we expand the feasibility of this platform in terms of exploring its ability to also deliver hydrophobic drugs, as well as investigate the effect of particle shape on intracellular delivery of both a hydrophilic and hydrophobic anticancer drug. MSN@PDA loaded with doxorubicin (hydrophilic) and fingolimod (hydrophobic) was studied via a systematic in vitro approach (cellular internalization, intracellular drug distribution and cytotoxicity). To promote the cellular uptake of the MSN@PDA particles, they were further coated with a polyethylene imine (PEI)-polyethylene glycol (PEG) copolymer. Drug-loaded, copolymer-coated MSN@PDA showed effective cellular uptake, intracellular release and an amplified cytotoxic effect with both doxorubicin and fingolimod. Additionally, rods exhibited delayed intracellular drug release and superior intracellular uptake compared to spheres. Hence, the study provides an example of how the choice and design of drug delivery systems can be tuned by the need for performance, and confirms the PDA coating of MSNs as a useful drug delivery platform beyond hydrophilic drugs.

Chitosan Based Nanoparticles in Drug Delivery

2009 ◽  
Vol 2 (2) ◽  
pp. 517-522 ◽  
Author(s):  
J. K. Patel ◽  
N. P. Jivani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chitosan Nanoparticles ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
Natural Polymers ◽  
Different Characteristics ◽  
Hydrophilicity And Hydrophobicity ◽  
Nanoparticulate Systems ◽  
Natural And Synthetic

Nanoparticles have gained considerable attention in recent years as one of the most promising drug delivery systems owing to their unique potentials via combining the different characteristics of hydrophilicity and hydrophobicity with a nanoparticle (e.g., very small size). Several polymeric nanoparticulate systems have been prepared and characterized in recent years, based on both natural and synthetic polymers, each with its own advantages and drawbacks. Among the natural polymers, chitosan has been studied extensively for preparation of nanoparticles.  Chitosan nanoparticles have been reported with different characteristics with respect to drug delivery. This review presents various types of chitosan based nanoparticles in drug delivery.

Drug Delivery Systems and Strategies to Overcome the Barriers of Brain

2021 ◽  
Vol 28 ◽  
Author(s):  
Yogesh Garg ◽  
Deepak N Kapoor ◽  
Abhishek Kumar Sharma ◽  
Amit Bhatia
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Brain Barrier ◽  
Olfactory Pathway ◽  
Hydrophilic Drugs ◽  
Blood Brain ◽  
Effective Delivery ◽  
The Brain

Abstract: The transport of drugs to the central nervous system is the most challenging task for conventional drug delivery systems. Reduced permeability of drugs through the blood-brain barrier is a major hurdle in delivering drugs to the brain. Hence, various strategies for improving drug delivery through the blood-brain barrier are currently being explored. Novel drug delivery systems (NDDS) offer several advantages, including high chemical and biological stability, suitability for both hydrophobic and hydrophilic drugs, and can be administered through different routes. Furthermore, the conjugation of suitable ligands with these carriers tend to potentiate targeting to the endothelium of the brain and could facilitate the internalization of drugs through endocytosis. Further, the intranasal route has also shown potential, as a promising alternate route, for the delivery of drugs to the brain. This can deliver the drugs directly to the brain through the olfactory pathway. In recent years, several advancements have been made to target and overcome the barriers of the brain. This article deals with a detailed overview of the diverse strategies and delivery systems to overcome the barriers of the brain for effective delivery of drugs.

scholarly journals RECENT ADVANCES IN ELASTIN-BASED BIOMATERIALS

2020 ◽  
Vol 23 ◽  
pp. 314-332
Author(s):  
María Luisa Del Prado Audelo ◽  
Néstor Mendoza-Muñoz ◽  
Lidia Escutia-Guadarrama ◽  
David Giraldo-Gomez ◽  
Maykel González-Torres ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
The Other ◽  
Main Components ◽  
Similar Conformation

Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformation and structure to elastin, but these possess the advantage of solubility in aqueous mediums. Due to their biological activities and physicochemical properties, elastin and related peptides may be applied as biomaterials to develop diverse biomedical devices, including scaffolds, hydrogels, and drug delivery systems for tissue engineering. Likewise, the combination of elastin with natural or synthetic polymers has demonstrated to improve the mechanical properties of biomedical products and drug delivery systems. Here we comprehensively describe the physicochemical properties and physiological functions of elastin. Moreover, we offer an overview of the use of elastin and its derivative polymers as biomaterials to develop scaffolds and hydrogels for tissue engineering. Finally, we discuss some perspectives on the employment of these biopolymers to fabricate new biomedical products.

scholarly journals Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1191 ◽  
Author(s):  
Saliha Durak ◽  
Monireh Esmaeili Rad ◽  
Abuzer Alp Yetisgin ◽  
Hande Eda Sutova ◽  
Ozlem Kutlu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Defense Mechanisms ◽  
Drug Delivery Systems ◽  
Genetic Disorders ◽  
Drug Loading ◽  
Active Role ◽  
Delivery Systems ◽  
Drug Bioavailability ◽  
Hydrophilic Drugs ◽  
Complex Anatomy

The eye is a complex organ consisting of several protective barriers and particular defense mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual impairments it is essential to provide necessary drugs through the appropriate delivery routes and vehicles. The topical route of administration, as the most commonly used approach, maybe inefficient due to low drug bioavailability. New generation safe, effective, and targeted drug delivery systems based on nanocarriers have the capability to circumvent limitations associated with the complex anatomy of the eye. Nanotechnology, through various nanoparticles like niosomes, liposomes, micelles, dendrimers, and different polymeric vesicles play an active role in ophthalmology and ocular drug delivery systems. Niosomes, which are nano-vesicles composed of non-ionic surfactants, are emerging nanocarriers in drug delivery applications due to their solution/storage stability and cost-effectiveness. Additionally, they are biocompatible, biodegradable, flexible in structure, and suitable for loading both hydrophobic and hydrophilic drugs. These characteristics make niosomes promising nanocarriers in the treatment of ocular diseases. Hereby, we review niosome based drug delivery approaches in ophthalmology starting with different preparation methods of niosomes, drug loading/release mechanisms, characterization techniques of niosome nanocarriers and eventually successful applications in the treatment of ocular disorders.

Current Designs and Developments of Fucoidan-based Formulations for Cancer Therapy

2020 ◽  
Vol 20 (12) ◽  
pp. 933-941 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Agent ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Functional Material ◽  
Nanostructure Materials ◽  
Bioactive Properties ◽  
Review Current ◽  
Structure Properties

Background: Natural nanostructure materials have been involved in antitumor drug delivery systems due to their biocompatibility, biodegradation, and bioactive properties. Methods: These materials have contributed to advanced drug delivery systems in the roles of both bioactive compounds and delivery nanocarriers. Fucoidan, a valuable ocean material used in drug delivery systems, has been exploited in research on cancer and a variety of other diseases. Results: Although the uniqueness, structure, properties, and health benefits of fucoidan have been mentioned in various prominent reviews, current developments and designs of fucoidan-based formulations still need to be assessed to further develop an effective anticancer therapy. In this review, current important formulations using fucoidan as a functional material and as an anticancer agent will be discussed. This article will also provide a brief principle of the methods that incorporate functional nanostructure materials in formulations exploiting fucoidan. Conclusion: Current research and future perspectives on the use of fucoidan in anticancer therapy will advance innovative and important products for clinical uses.

scholarly journals Niosomes as Nanoparticular Drug Carriers: Fundamentals and Recent Applications

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Didem Ag Seleci ◽  
Muharrem Seleci ◽  
Johanna-Gabriela Walter ◽  
Frank Stahl ◽  
Thomas Scheper
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Nonionic Surfactants ◽  
Drug Carriers ◽  
Delivery Systems ◽  
The Body ◽  
Scientific Journals ◽  
Preparation Methods ◽  
Different Types ◽  
Self Association

Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area of action within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Based on their biodegradable, biocompatible, and nonimmunogenic structure, niosomes are promising drug carriers that are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. In recent years, numerous research articles have been published in scientific journals reporting the potential of niosomes to serve as a carrier for the delivery of different types of drugs. The present review describes preparation methods, characterization techniques, and recent studies on niosomal drug delivery systems and also gives up to date information regarding recent applications of niosomes in drug delivery.

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