Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs

2016 ◽  
Vol 17 (3) ◽  
pp. 248-255 ◽  
Author(s):  
Dominique Duchene ◽  
Roberta Cavalli ◽  
Ruxandra Gref
Keyword(s):  
Anticancer Drugs ◽  
Polymeric Nanoparticles

Coumarin polycaprolactone polymeric nanoparticles: light and tumor microenvironment activated cocktail drug delivery

2017 ◽  
Vol 5 (9) ◽  
pp. 1734-1741 ◽  
Author(s):  
S. Karthik ◽  
Avijit Jana ◽  
M. Selvakumar ◽  
Yarra Venkatesh ◽  
Amrita Paul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Highly Sensitive

Highly sensitive hypoxia (H2O2)-activated photoresponsive polymeric nanoparticles for cocktail delivery of anticancer drugs doxorubicin (Dox) and chlorambucil (Cbl) were developed.

scholarly journals Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Shakeri-Zadeh ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Ali Mohammad Sharifi ◽  
Mohammad-Bagher Shiran
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Chemotherapeutic Agents ◽  
Drug Uptake ◽  
Cancerous Cell ◽  
Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

scholarly journals Targeted Delivery System of Nanobiomaterials in Anticancer Therapy: From Cells to Clinics

2014 ◽  
Vol 2014 ◽  
pp. 1-23 ◽  
Author(s):  
Su-Eon Jin ◽  
Hyo-Eon Jin ◽  
Soon-Sun Hong
Keyword(s):  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Polymeric Nanoparticles ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Specific Receptors ◽  
Targeted Delivery System ◽  
Targeted Delivery Systems

Targeted delivery systems of nanobiomaterials are necessary to be developed for the diagnosis and treatment of cancer. Nanobiomaterials can be engineered to recognize cancer-specific receptors at the cellular levels and to deliver anticancer drugs into the diseased sites. In particular, nanobiomaterial-based nanocarriers, so-called nanoplatforms, are the design of the targeted delivery systems such as liposomes, polymeric nanoparticles/micelles, nanoconjugates, norganic materials, carbon-based nanobiomaterials, and bioinspired phage system, which are based on the nanosize of 1–100 nm in diameter. In this review, the design and the application of these nanoplatforms are discussed at the cellular levels as well as in the clinics. We believe that this review can offer recent advances in the targeted delivery systems of nanobiomaterials regardingin vitroandin vivoapplications and the translation of nanobiomaterials to nanomedicine in anticancer therapy.

Acid-Responsive Endosomolytic Polymeric Nanoparticles with Amplification of Intracellular Oxidative Stress for Prodrug Delivery and Activation

2021 ◽  
Author(s):  
Nannan Lu ◽  
Longchang Xi ◽  
Zengshi Zha ◽  
Yuheng Wang ◽  
Xinghua Han ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anticancer Drugs ◽  
High Efficiency ◽  
Polymeric Nanoparticles ◽  
In Situ Activation ◽  
Intracellular Oxidative Stress

Prodrug strategy especially in the field of chemotherapy of cancers possesses significant advantages to reduce the side toxicity of anticancer drugs. However, high-efficiency delivery and in situ activation of prodrugs...

scholarly journals Quality by design (QbD) approach in processing polymeric nanoparticles loading anticancer drugs by high pressure homogenizer

Heliyon ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. e03846
Author(s):  
Govind Soni ◽  
Ketaki Kale ◽  
Saritha Shetty ◽  
M.K. Gupta ◽  
Khushwant S. Yadav
Keyword(s):  
High Pressure ◽  
Anticancer Drugs ◽  
Quality By Design ◽  
Polymeric Nanoparticles ◽  
High Pressure Homogenizer
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