A Concise overview of phytochemistry, pharmacology and clinical aspects of Persian Cumin; Bunium persicum (Boiss.) B.Fedtsch

2020 ◽  
Vol 17 ◽  
Author(s):  
Mahkameh Moradi Mehrabadi ◽  
Mohammad M. Zarshenas
Keyword(s):  
Experimental Investigations ◽  
Clinical Aspects ◽  
Pharmacological Activities ◽  
Important Species ◽  
Bunium Persicum ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Antimicrobial And Antifungal Activities ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds

: Bunium persicum is one of the most medically and economically important species of Apiaceae family. Despite variety of phytochemical and experimental research on this species, there is no considerable update on all related outcomes. Accordingly, current work compiles an overview on Cumin’s phytochemical and pharmacological activities. Papers related to phytochemistry, pharmacology and clinical properties of B. persicum were filtered from databases as PubMed, ScienceDirect and Scopus with the term "Bunium persicum" till 15th May 2020. Genetic, pure pharmaceutical and agriculture papers were excluded. Moreover, traditional applications of this herb in Persian medicine were studied and included. In all, 54 papers reporting the compositions, Anticonvulsant, antinociceptive, anti-inflammatory, antioxidant, anti-glycation, antidiarrhea, anti-hematotoxic, anti-toxoplasmosis, hypoglycemic, larvicidal, scolicidal, anticholinergic and antihistaminic activities of B. persicum as well as reducing and stabilizing effects in nanoparticles. Three clinical trials have also been conducted on B. persicum. There are also numerous effects, cited in traditional manuscripts such as gastroprotective, kidney tonic, slimming activity and antidote for poisons. Most dominant chemical composition of Cumin is the essential oil, responsible for various potent antimicrobial and antifungal activities. The herb also contain phenolic and flavonoid compounds which reflect the antioxidant and anti-inflammatory activities. Many of the experimental and pharmacological studies on B. persicum have traces in traditional manuscripts. There are also medical aspects which have not yet been evaluated. Despite various experimental investigations, lack of extensive clinical studies which is currently limited to few trials on remarked activities of B. persicum is still remained to be covered.

Cytotoxicity and anti-inflammatory effects of polyherbal formulations, Joint Pain Spl and Rumalaya Forte on lipopolysaccharide induced inflammation in IC-21 macrophages

2021 ◽  
Vol 19 ◽  
Author(s):  
Arunagirinathan Koodalingam ◽  
Arumugam Rajalakshmi ◽  
Ezhumalai Parthiban
Keyword(s):  
Free Radical ◽  
Mtt Assay ◽  
Joint Pain ◽  
Inflammatory Activity ◽  
Scavenging Activity ◽  
Herbal Plants ◽  
Anti Inflammatory ◽  
Herbal Formulations ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds

Aim: To test the effectiveness of marketed polyherbal formulations on lipopolysaccharide induced inflammatory conditions in macrophages. Background: Usage of herbal compounds among patients suffered by arthritis and cancer is increasing every year. Many anti-inflammatory herbal products available in the market should be screened thoroughly for their possible mechanism of action. Objective: Joint Pain Spl (JPS) is a polyherbal dietary food supplement composed of 13 herbal plants and Rumalaya Forte (RF) is a polyherbal formulation comprising of 6 herbal plants were tested for its cytotoxicity, as well as antioxidant and anti-inflammatory activity in LPS treated IC-21 peritoneal macrophages. Methods: Commercially available JPS and RF powder was used to prepare the extract. The aqueous and methanol extracts were quantified for the presence of phenolic and flavonoid compound and confirmed with HPLC. In vitro DPPH free scavenging activity was performed. Cytotoxicity was tested by MTT assay. Anti-inflammatory activity was tested using lipopolysaccharide stimulated IC-21 peritoneal macrophage cells. Results: The phytochemical screening showed the presence of phenolic and flavonoid compounds in JPS and RF. The aqueous and methanol extracts of JPS and RF possesses significant DPPH free radical scavenging activity. MTT assay revealed that 90.64% (aqueous extract) and 92.21% (methanol extract) of exposed macrophages are viable even after 24h exposure of maximal tested concentrations of herbal formulations. Pre-treatment of JPS and RF on LPS induced IC-21 macrophages showed an reduction in nitric oxide production (maximal 79.95%) and high level of superoxide anion scavenging activity (maximal 82.5%) over control. Conclusion: The two tested poly herbal formulations such as JPS and RF possesses anti-inflammatory activity by modulating free radical generation in IC-21 macrophages. Thus the presence of the phenolic and flavonoid compounds may contribute to the antioxidant activity.

Antioxidant and Anti-inflammatory Activities of Selected Medicinal Plants Containing Phenolic and Flavonoid Compounds

2011 ◽  
Vol 59 (23) ◽  
pp. 12361-12367 ◽  
Author(s):  
Lin Zhang ◽  
Anjaneya S. Ravipati ◽  
Sundar Rao Koyyalamudi ◽  
Sang Chul Jeong ◽  
Narsimha Reddy ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Flavonoid Compounds ◽  
Anti Inflammatory ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds

scholarly journals Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fen Liu ◽  
Luning Li ◽  
Xinchen Tian ◽  
Dengtian Zhang ◽  
Wenxue Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Animal Models ◽  
Chemical Constituents ◽  
Herbal Drugs ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Comprehensive Exploitation ◽  
Paris Polyphylla ◽  
Pharmacological Studies ◽  
Anti Inflammatory

Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

scholarly journals Analytical Profile of an Unparalleled Drug Tinospora crispa W.R.T Guduchi

2021 ◽  
pp. 195-203
Author(s):  
S. Lekshmipriya ◽  
M. R. Pandya ◽  
Bijal Prajapati
Keyword(s):  
Research Study ◽  
Pharmacological Activities ◽  
Important Species ◽  
Traditional Medicines ◽  
Flavone Glycosides ◽  
Therapeutic Benefits ◽  
Research Article ◽  
The Family ◽  
Current Article ◽  
Anti Inflammatory

Introduction: Guduchi is a highly potential drug which is mentioned in Ayurveda classics. The clinical utility of this drug is widely known. The Tinospora species are wrapped under the broad spectrum Guduchiin the Ayurveda classics. Tinospora is one of the important genera of the family, consisting of about 15 species. Some medicinally important species includes T. cordifolia, T. malabarica, T. tomentosa, T. crispa, T. uliginosa, T. crispaetc. In the current article the drug Tinospora crispa is considered in detail.Tinospora crispa is used irrationally by the society owing to its various therapeutic benefits. Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae), found in the rainforests or mixed deciduous forests in Asia and Africa, is used in traditional medicines to treat numerous health conditions. Materials & Methods: A detailed review of the drug has been carried out through the available literature. After considering the review the analytical profiling of the drug has been done.The phytochemical analyses review of T. crispa revealed the presence of alkaloids, flavonoids, and flavone glycosides, triterpenes, diterpenes and diterpene glycosides, cis clerodane-type furanoditerpenoids, lactones, sterols, lignans, and nucleosides. The literary review showed that the crude extracts and isolated compounds of T. crispa possessed a broad range of pharmacological activities such as anti-inflammatory, antioxidant, immunomodulatory, cytotoxic, antimalarial, cardioprotective, and anti-diabetic activities.So, in the current research study a sincere attempt has been made to study regarding the drug Tinospora crispa through its analytical profile. Results: Through this research article able to make out the available literature and the analytical profile of the drug Tinospora crispa. Discussion: The current analytical profile reveals the presence of alkaloids, tannins, flavonoids, saponins etc which directly connects to the various activities like Anti-pyretic, Anti- inflammatory, Antioxidant etc of the drug Tinospora crispa. Conclusion: The current research study points towards the review of the drug and the analytical profile which is beneficial to carry out the next phase of research studies in connection with this drug Tinospora crispa.

scholarly journals Antioxidant and anti-inflammatory activities of selected medicinal plants and fungi containing phenolic and flavonoid compounds

2012 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
Patricia Diaz ◽  
Sang Chul Jeong ◽  
Samiuela Lee ◽  
Cheang Khoo ◽  
Sundar Rao Koyyalamudi
Keyword(s):  
Medicinal Plants ◽  
Flavonoid Compounds ◽  
Anti Inflammatory ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds

scholarly journals Potential uses of Hylocereus undatus (Haworth) Britton & Rose byproducts: antimicrobial activity and flavonoid content from aerial parts extracts

2019 ◽  
Vol 13 (51) ◽  
pp. 9-20
Author(s):  
Mariana Torres-Olvera ◽  
Juan Rodrigo Salazar ◽  
Inés Nogueda-Gutiérrez ◽  
Diego Soto-Cabrera ◽  
Anabelle Cerón-Nava ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Fatty Acid Esters ◽  
Total Phenolic ◽  
Dilution Method ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Hylocereus Undatus ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds ◽  
Acid Esters

To determine the possible uses of Hylocereus undatus aerial parts byproducts as anti-inflammatory and antimicrobial agents, the organic extracts were obtained and evaluated using the TPA-induced mice ear edema, and the tube-macro-dilution method respectively. The colorimetric quantification of total phenolic and flavonoid compounds as well as the identification by GC-MS of non-polar metabolites was performed. In the evaluation of anti-inflammatory activity, the methanolic extract showed 25.16 % of edema inhibition. In the anti-microbial assays, all extracts showed inhibition against all strains, mostly against C. albicans. On the other hand, all extracts showed the presence of polyphenols and flavonoids. Finally, the GC-MS analysis revealed the presence of β-sitosterol, and 4-methoxycynnamic acid and other non-polar molecules like fatty acid esters. The study demonstrated that H. undatus byproducts can be used as a source of antifungal agents.

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

2019 ◽  
Vol 25 (6) ◽  
pp. 715-728 ◽  
Author(s):  
Hai-Yue Lan ◽  
Bin Zhao ◽  
Yu-Li Shen ◽  
Xiao-Qin Li ◽  
Su-Juan Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southeast Asia ◽  
Clinical Application ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

Medicinal and Biological Significance of Phenoxazine Derivatives

2020 ◽  
Vol 20 ◽  
Author(s):  
Jaya Dwivedi ◽  
Neetu Yaduvanshi ◽  
Shruti Shukla ◽  
Sonika Jain
Keyword(s):  
Drug Resistance ◽  
Biological Significance ◽  
Biological Application ◽  
Pharmacological Activities ◽  
Resistance Reversal ◽  
Anti Inflammatory ◽  
Pharmacological Application

: Since 1887, phenoxazine derivatives have attracted attention of chemist due to its versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, antidepressant, analgesic and many other drug resistance reversal activities. This review covers detailed over-view on pharmacological application of phenoxazine nucleus, its chemistry and reactivity and also illustrating the incorporation of different group at different positions enhancing its biological application, besides some synthetic procedures.

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