Changes in physiological variables in patients with diffuse interstitial lung disease in the six-minute walk test

Objective: Diffuse Interstitial Lung Disease (DILD) is a pathology with a high mortality rate in Colombia as well as around the world. Linking patients to pulmonary rehabilitation programs is essential to improve their quality of life and aerobic capacity; thus, all patients perform the six-minute walk test (6-MWT). This study aimed to describe the changes in physiological and aerobic capacity-related variables in patients with DILD in the 6-MWT at admission to a pulmonary rehabilitation program and determine possible differences between patients with idiopathic pulmonary fibrosis (IPF) and other DILDs. Methods: This is a cross-sectional descriptive study on patients with DILD who performed the 6-MWT between January 2017 and February 2019. Sociodemographic, clinical, physiological, and exercise tolerance variables were taken into account at four different times of the 6-MWT: Rest time, the end, and the first and the fifth minute after the end of the test. The Human Ethics Committee endorsed the study, and all participants signed the informed consent form. Results: There were 64 patients with DILD. The average age was 60.84 years, 53.1% were female, 73.4% required home oxygen, and 53.1% had a diagnosis of IPF. There were no statistically significant differences in the heart rate (HR), respiratory rate (RR), peripheral oxygen saturation (SpO2), Borg scale, and fatigue in lower limbs at the four evaluated moments of the test for both groups of patients with DILD (p=0.000); moreover, the FEV1/FVC ratio for patients with other DILD was higher (p=0.000). The distance traveled for IPF was 339.26±124.84, while for other DILDs, it was 365.63±113.00 (p=0.382). Conclusions: Patients with other DILDs have better FEV1/FVC and travel longer distances with less dyspnea and fatigue than patients with IPF during the 6-MWT. Both groups' HR, RR, SpO2, Borg, and fatigue variables presented significant changes during the 6-MWT.

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Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease

Canadian Respiratory Journal ◽

10.1155/2016/3837182 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Osamu Nishiyama ◽

Ryo Yamazaki ◽

Hiroyuki Sano ◽

Takashi Iwanaga ◽

Yuji Higashimoto ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Walk Test ◽

Walk Distance ◽

Right Heart ◽

Pulmonary Hemodynamics ◽

Physiological Variables ◽

Six Minute Walk Test ◽

Right Heart Catheter ◽

Minute Walk

Background. Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT outcomes in patients with interstitial lung disease (ILD).Methods. Between June 2010 and December 2012, consecutive patients with ILD who underwent evaluation, including pulmonary function test, hemodynamic studies with right-heart catheter, and 6MWT as routine general practice, were recruited. Correlates of 3 outcomes of 6MWT were examined to reveal significant predictors.Results. Forty-six patients consisting of 20 with idiopathic pulmonary fibrosis, 14 with collagen vascular disease associated ILD, and 12 with other idiopathic interstitial pneumonia were recruited (mean % predicted FVC:76.7±17.1%). Several physiological variables, including mean pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), were correlated with each 6MWT outcome. Stepwise multivariate regression analyses showed that % predicted FVC and % predicted DLco were independent predictors of walk distance (r2=0.35,p=0.0002). For SpO2at the end of 6MWT, % predicted DLco and PVR were selected as independent predictors (r2=0.46,p<0.0001). For dyspnea at the end of 6MWT, % predicted DLco was only one predictor (r2=0.18,p=0.005).Conclusion. Mean PAP had little impact on 6MWT outcomes in ILD patients who were nonselectively recruited, although PVR was one of predictors of desaturation.

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