Prospect for type 2 diabetes mellitus in the combination of exercise and synbiotic: a perspective

: Change in gut microbiome diversity (the so-called dysbiosis) is correlated with insulin resistance conditions. Exercise is typically one of the first management for people with type 2 diabetes mellitus (T2DM), which is generally well-known for improved glucose regulation. The new design of prebiotic and probiotic, like synbiotic form, to target specific diseases is needed for additional studies. While the effectiveness of exercise and the combination of exercise and synbiotic prescription seems promising, this review discusses the possibility of these agents to increase the diversity of gut microbiota and therefore could enhance short-chain fatty acid (SCFA). In particular, the interaction of synbiotic towards gut microbiota, the mechanism of exercise in improving gut microbiota, and the prospect of the synergistic effect of the combination of synbiotic and exercise to improve insulin sensitivity is addressed.