Editorial [Translational Research and Clinical Applications of Modern Imaging]

‘Translational research’ encompasses all activities that apply basic scientific research findings to clinical practice. Although it has taken almost 20 years since the first scientific discoveries, the approval of new ‘drugs’ such as Herceptin and Avastin represents a successful example. There has also been successful translation of science into the clinic in the field of otolaryngology.In the last decade, we have seen major developments in molecular biology and genetics. Two notable achievements have been the completion of the human genome project and the parallel advances in high-throughput molecular genomic and proteomic technologies. Linked with these events has been the enormous accumulation of new data which offers the promise of important future clinical applications.This review aims to discuss these major scientific developments, to demonstrate successes in thyroid translational research, and to summarise more recent research findings in thyroid disease which provide hope for the development of future clinical tools.

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TraIT, Translational research IT bridging the valley of death in translational medicine

10.1101/2020.05.18.052563 ◽

2020 ◽

Author(s):

Jan-Willem Boiten ◽

Rita Azevedo ◽

Kees van Bochove ◽

Marinel Cavelaars ◽

André Dekker ◽

...

Keyword(s):

Translational Research ◽

Translational Medicine ◽

Large Scale ◽

New Technology ◽

Clinical Applications ◽

User Support ◽

User Community ◽

On Line ◽

Valley Of Death

Translating new technology and biological findings into clinical applications is hampered by insufficient translational research IT. The Dutch Translational research IT (TraIT) initiative organizes, deploys, and manages data and workflows in an on-line “office suite”, supplemented with efficient training and user support. TraIT has been adopted by a wide user community providing an excellent large-scale demonstrator for the nation-wide Health-RI initiative.

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Protein biomarkers in gynecological cancers: The need for translational research towards clinical applications

Clínica e Investigación en Ginecología y Obstetricia ◽

10.1016/j.gine.2021.100735 ◽

2022 ◽

Vol 49 (2) ◽

pp. 100735

Author(s):

G. Kumarasamy ◽

G. Kaur

Keyword(s):

Translational Research ◽

Clinical Applications ◽

Gynecological Cancers ◽

Protein Biomarkers

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Synovial biopsies in clinical practice and research: current developments and perspectives

Clinical Rheumatology ◽

10.1007/s10067-020-05512-7 ◽

2020 ◽

Author(s):

Hanna Johnsson ◽

Aurélie Najm

Keyword(s):

Translational Research ◽

Clinical Applications ◽

Synovial Biopsy ◽

Ultrasound Guided ◽

Histological Studies ◽

Training Requirements ◽

The Past ◽

Cell Subpopulations ◽

And Training ◽

Clinical And Translational Research

AbstractSynovial biopsy techniques have developed and widely expanded over the past few years, in particular due to the development of ultrasound-guided procedures. This article reviews the different techniques, clinical applications, and the latest advances in translational research as well as current challenges and perspectives. The first part focuses on different techniques available for biopsy, along with their feasibility, success rate, tolerance, and training requirements. In the second part, clinical applications are described. Data on diagnostic performances are reported, especially regarding septic arthritis. Translational research applications are described and explained in the final part, from the early histological studies and the first description of pathotype to more recent technologies involving -omics. Latest developments involving single-cell RNA sequence analysis have allowed the discovery of new cell subpopulations with remarkable roles in RA pathophysiology. These studies pave the ground for the discovery of new therapeutic targets and the implementation of personalized therapy in RA. Key Point•This review provides an overview of synovial biopsy techinques and applications especially in clinical and translational research.

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Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2012.10.039 ◽

2013 ◽

Vol 46 (6) ◽

pp. 466-479 ◽

Cited By ~ 56

Author(s):

Meike de Wit ◽

Remond J.A. Fijneman ◽

Henk M.W. Verheul ◽

Gerrit A. Meijer ◽

Connie R. Jimenez

Keyword(s):

Colorectal Cancer ◽

Translational Research ◽

Biomarker Discovery ◽

Clinical Applications

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Pathways from science findings to health benefits

Psychological Medicine ◽

10.1017/s003329170800398x ◽

2008 ◽

Vol 39 (4) ◽

pp. 529-542 ◽

Cited By ~ 15

Author(s):

M. Rutter ◽

R. Plomin

Keyword(s):

Translational Research ◽

Applied Research ◽

Health Benefits ◽

Time Frame ◽

Clinical Applications ◽

Experimental Medicine ◽

False Dichotomy ◽

Challenges And Opportunities ◽

Basic And Applied Research ◽

Bridging Studies

There have been numerous exhortations for more ‘translational research’. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscience findings that might be relevant for translation, and then by a discussion of the challenges and opportunities in relation to mental disorders. The time-frame for the pathway from science findings to health benefits is usually long, and generally requires an interactive interplay among different scientific strategies. There is a false dichotomy between so-called basic and applied research and translation needs to proceed from the bedside to the laboratory as well as in the opposite direction. There is a key need for bridging research of the hypothesis-testing experimental medicine variety. Health benefits may involve either public health considerations or the treatment of individual patients, or both. There are now some opportunities for direct translational research but there is a much greater need for hypothesis-based bridging studies that occupy a crucial mid-phase in the pathway from science findings to health benefits.

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