scholarly journals Synovial biopsies in clinical practice and research: current developments and perspectives

Author(s):  
Hanna Johnsson ◽  
Aurélie Najm

AbstractSynovial biopsy techniques have developed and widely expanded over the past few years, in particular due to the development of ultrasound-guided procedures. This article reviews the different techniques, clinical applications, and the latest advances in translational research as well as current challenges and perspectives. The first part focuses on different techniques available for biopsy, along with their feasibility, success rate, tolerance, and training requirements. In the second part, clinical applications are described. Data on diagnostic performances are reported, especially regarding septic arthritis. Translational research applications are described and explained in the final part, from the early histological studies and the first description of pathotype to more recent technologies involving -omics. Latest developments involving single-cell RNA sequence analysis have allowed the discovery of new cell subpopulations with remarkable roles in RA pathophysiology. These studies pave the ground for the discovery of new therapeutic targets and the implementation of personalized therapy in RA. Key Point•This review provides an overview of synovial biopsy techinques and applications especially in clinical and translational research.

1991 ◽  
Vol 7 (03) ◽  
pp. 176-182
Author(s):  
John Walker Hartigan

The naval shipyards are in the process of installing a system for identifying and recording specific job-related skills in their industrial workforce. The system, called the Shipyard Skills Tracking System (SSTS), is intended initially to support middle-level management in allocating their workforce properly for critical tasks and in accurately factoring personnel availability and training requirements into the planning for upcoming work. SSTS is supported by sophisticated computer programs which are integrated into other shipyard administrative programs. Data entry, ever the bugaboo of large-scale tracking programs, is minimized by using data links to other job-related programs for most of the information. The programs have been successfully field-tested at one naval shipyard and, starting in November 1989, began undergoing phased installation at all eight government yards. Discussion John D. Prebula, Pearl Harbor Naval Shipyard This paper is an excellent overview of how shipyards will track qualifications, skills, skill level, and other data needed to assign work. The SSTS is a good example of what can happen when appropriate technology is used to satisfy similar needs at a number of naval shipyards. The naval shipyards had a problem where they knew a great deal about the training and qualifications of individuals but had poor means of retrieving the information on their skill level. Attempts in the past to document and retain the information on skill levels and experience were generally unsuccessful because of the large amount of information and the continuing changes in the information. The SSTS successfully linked new microcomputer technology and training information in the shipyard main-frame computer. This allows information to be maintained currently and easily without the large duplication of effort that had been necessary in the past. Pearl Harbor Naval Shipyard's supervisors are looking forward to full implementation of the SSTS and believe that if properly implemented it will be of benefit to the shipyard. Mr. Hartigan does an excellent job of listing and explaining the important features of the SSTS and uses the example of a new supervisor trying to provide someone for a "tiger team" effort. While such a system is definitely a benefit to new supervisors it is also a great benefit to supervisors who have been on the job and know the people rather well. An experienced supervisor who is familiar with his people is still not likely to know such things as:who has passports, the currency of medical exams, the currency of inoculations, and, the other things necessary to be checked out before someone can be sent overseas or to a specific shipyard job. When the workforce is composed of a large number of temporary or more transient workers (as shipyards are being asked to become), the importance of a system to track skills becomes more important than ever. The SSTS, as the author explains so well, is not just another system of tracking qualifications. Rather, it marries together qualifications, skills, skill levels, some select training, medical qualifications and selected attributes such as the possession of a passport. This database is updated for training and qualification whenever the shipyard's mainframe is updated for these trainings and qualifications. The SSTS is manually updated for the specific attributes and skills. It was the marrying of the microcomputer technology to the shipyard's main-frame computer that allowed such a system to come into existence without the need for the purchase of additional computer equipment. As planned, the shipyard's SSTS system will be applicable to the production department workers for all ships in the shipyard and will be applied to selected engineering and inspection codes. One significant item in the paper is the mention that not only are the skills and experience reported and tracked, but the degree of expertise in each of these skills is also tracked. Mr. Hartigan uses the words "accomplished a battery replacement successfully." This allows the shipyard not only to track who has performed specific skills or tasks, but to know at what level they are capable of performing. This is done by a tie between the timekeeping system and the SSTS, allowing the supervisors to annotate the skill level when an individual has done a specific skill by entering the appropriate coding on the timekeeping sheet. This timekeeping entry also provides direct input into the SSTS.


1975 ◽  
Vol 5 (4) ◽  
pp. 261-275
Author(s):  
Roger H. Bezdek ◽  
Barry Getzel

This paper presents estimates of the education and training requirements for detailed scientific and engineering occupations. GED and SVP levels are translated into yearly equivalents and the variances in these requirements are derived for the same occupation in different industries and for different occupations in the same industry. The changes in education and training requirements for scientists and engineers in the past decade are estimated and educational attainment in these occupations is compared to occupational requirements. Some implications of the findings presented here are briefly discussed and several serious deficiencies in U.S. occupational data are identified.


Author(s):  
Glenn Martin ◽  
Sae Schatz ◽  
Clint Bowers ◽  
Charles E. Hughes ◽  
Jennifer Fowlkes ◽  
...  

We discuss our current efforts at developing automatic scenario generation software. We begin by explaining the rationale, and then review successful previous efforts. We discuss the lessons-learned from the past work, and the conceptual pieces that are required to generate operationally-valid scenarios that support effective training. We then present the conceptual design of our scenario generation approach, which uses novel procedural modeling approaches to ensure operational and training requirements are adequately met.


2020 ◽  
Vol 16 (4) ◽  
pp. 291-300
Author(s):  
Zhenyu Gao ◽  
Yixing Li ◽  
Zhengxin Wang

AbstractThe recently concluded 2019 World Swimming Championships was another major swimming competition that witnessed some great progresses achieved by human athletes in many events. However, some world records created 10 years ago back in the era of high-tech swimsuits remained untouched. With the advancements in technical skills and training methods in the past decade, the inability to break those world records is a strong indication that records with the swimsuit bonus cannot reflect the real progressions achieved by human athletes in history. Many swimming professionals and enthusiasts are eager to know a measure of the real world records had the high-tech swimsuits never been allowed. This paper attempts to restore the real world records in Men’s swimming without high-tech swimsuits by integrating various advanced methods in probabilistic modeling and optimization. Through the modeling and separation of swimsuit bias, natural improvement, and athletes’ intrinsic performance, the result of this paper provides the optimal estimates and the 95% confidence intervals for the real world records. The proposed methodology can also be applied to a variety of similar studies with multi-factor considerations.


Author(s):  
LaKaija J. Johnson ◽  
Jolene Rohde ◽  
Mary E. Cramer ◽  
Lani Zimmerman ◽  
Carol R. Geary ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Muna Abed Rabbo ◽  
Yara Khodour ◽  
Laurie S. Kaguni ◽  
Johnny Stiban

AbstractJohann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late nineteenth century, but it was only in the past fifty years that SL research surged in importance and applicability. Currently, sphingolipids and their metabolism are hotly debated topics in various biochemical fields. Similar to other macromolecular reactions, SL metabolism has important implications in health and disease in most cells. A plethora of SL-related genetic ailments has been described. Defects in SL catabolism can cause the accumulation of SLs, leading to many types of lysosomal storage diseases (LSDs) collectively called sphingolipidoses. These diseases mainly impact the neuronal and immune systems, but other systems can be affected as well. This review aims to present a comprehensive, up-to-date picture of the rapidly growing field of sphingolipid LSDs, their etiology, pathology, and potential therapeutic strategies. We first describe LSDs biochemically and briefly discuss their catabolism, followed by general aspects of the major diseases such as Gaucher, Krabbe, Fabry, and Farber among others. We conclude with an overview of the available and potential future therapies for many of the diseases. We strive to present the most important and recent findings from basic research and clinical applications, and to provide a valuable source for understanding these disorders.


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