Protein biomarkers in gynecological cancers: The need for translational research towards clinical applications

2022 ◽  
Vol 49 (2) ◽  
pp. 100735
Author(s):  
G. Kumarasamy ◽  
G. Kaur
Keyword(s):  
Translational Research ◽  
Clinical Applications ◽  
Gynecological Cancers ◽  
Protein Biomarkers

Thyroid cancer: are molecular studies making any difference?

2007 ◽  
Vol 121 (10) ◽  
pp. 917-926
Author(s):  
D S Kim
Keyword(s):  
Thyroid Cancer ◽  
Translational Research ◽  
Human Genome Project ◽  
Clinical Applications ◽  
Genome Project ◽  
New Drugs ◽  
Molecular Studies ◽  
Research Findings ◽  
Clinical Tools ◽  
The Human Genome Project

‘Translational research’ encompasses all activities that apply basic scientific research findings to clinical practice. Although it has taken almost 20 years since the first scientific discoveries, the approval of new ‘drugs’ such as Herceptin and Avastin represents a successful example. There has also been successful translation of science into the clinic in the field of otolaryngology.In the last decade, we have seen major developments in molecular biology and genetics. Two notable achievements have been the completion of the human genome project and the parallel advances in high-throughput molecular genomic and proteomic technologies. Linked with these events has been the enormous accumulation of new data which offers the promise of important future clinical applications.This review aims to discuss these major scientific developments, to demonstrate successes in thyroid translational research, and to summarise more recent research findings in thyroid disease which provide hope for the development of future clinical tools.

scholarly journals Tumor-Associated Glycans and Their Role in Gynecological Cancers: Accelerating Translational Research by Novel High-Throughput Approaches

Metabolites ◽  
2012 ◽  
Vol 2 (4) ◽  
pp. 913-939 ◽  
Author(s):  
Tatiana Pochechueva ◽  
Francis Jacob ◽  
Andre Fedier ◽  
Viola Heinzelmann-Schwarz
Keyword(s):  
Translational Research ◽  
High Throughput ◽  
Gynecological Cancers

scholarly journals TraIT, Translational research IT bridging the valley of death in translational medicine

2020 ◽  
Author(s):  
Jan-Willem Boiten ◽  
Rita Azevedo ◽  
Kees van Bochove ◽  
Marinel Cavelaars ◽  
André Dekker ◽  
...  
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Large Scale ◽  
New Technology ◽  
Clinical Applications ◽  
User Support ◽  
User Community ◽  
On Line ◽  
Valley Of Death

Translating new technology and biological findings into clinical applications is hampered by insufficient translational research IT. The Dutch Translational research IT (TraIT) initiative organizes, deploys, and manages data and workflows in an on-line “office suite”, supplemented with efficient training and user support. TraIT has been adopted by a wide user community providing an excellent large-scale demonstrator for the nation-wide Health-RI initiative.

Accelerating protein biomarker discovery and translation from proteomics research for clinical utility

Bioanalysis ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 1469-1481
Author(s):  
Jiwen Chen ◽  
Naiyu Zheng
Keyword(s):  
Clinical Utility ◽  
Biomarker Discovery ◽  
Clinical Applications ◽  
Clinical Perspective ◽  
Significant Progress ◽  
Clinical Implementation ◽  
Protein Biomarkers ◽  
Protein Biomarker ◽  
The Past ◽  
Proteomics Research

Discovery proteomics research has made significant progress in the past several years; however, the number of protein biomarkers deployed in clinical practice remains rather limited. There are several scientific and procedural gaps between discovery proteomics research and clinical implementation, which have contributed to poor biomarker validity and few clinical applications. The complexity and low throughput of proteomics approaches have added additional barriers for biomarker assay translation to clinical applications. Recently, targeted proteomics have become a powerful tool to bridge the biomarker discovery to clinical validation. In this perspective, we discuss the challenges and strategies in proteomics research from a clinical perspective, and propose several recommendations for discovery proteomics research to accelerate protein biomarker discovery and translation for future clinical applications.

scholarly journals Synovial biopsies in clinical practice and research: current developments and perspectives

2020 ◽  
Author(s):  
Hanna Johnsson ◽  
Aurélie Najm
Keyword(s):  
Translational Research ◽  
Clinical Applications ◽  
Synovial Biopsy ◽  
Ultrasound Guided ◽  
Histological Studies ◽  
Training Requirements ◽  
The Past ◽  
Cell Subpopulations ◽  
And Training ◽  
Clinical And Translational Research

AbstractSynovial biopsy techniques have developed and widely expanded over the past few years, in particular due to the development of ultrasound-guided procedures. This article reviews the different techniques, clinical applications, and the latest advances in translational research as well as current challenges and perspectives. The first part focuses on different techniques available for biopsy, along with their feasibility, success rate, tolerance, and training requirements. In the second part, clinical applications are described. Data on diagnostic performances are reported, especially regarding septic arthritis. Translational research applications are described and explained in the final part, from the early histological studies and the first description of pathotype to more recent technologies involving -omics. Latest developments involving single-cell RNA sequence analysis have allowed the discovery of new cell subpopulations with remarkable roles in RA pathophysiology. These studies pave the ground for the discovery of new therapeutic targets and the implementation of personalized therapy in RA. Key Point•This review provides an overview of synovial biopsy techinques and applications especially in clinical and translational research.

Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications

2013 ◽  
Vol 46 (6) ◽  
pp. 466-479 ◽  
Author(s):  
Meike de Wit ◽  
Remond J.A. Fijneman ◽  
Henk M.W. Verheul ◽  
Gerrit A. Meijer ◽  
Connie R. Jimenez
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
Biomarker Discovery ◽  
Clinical Applications

Pathways from science findings to health benefits

2008 ◽  
Vol 39 (4) ◽  
pp. 529-542 ◽  
Author(s):  
M. Rutter ◽  
R. Plomin
Keyword(s):  
Translational Research ◽  
Applied Research ◽  
Health Benefits ◽  
Time Frame ◽  
Clinical Applications ◽  
Experimental Medicine ◽  
False Dichotomy ◽  
Challenges And Opportunities ◽  
Basic And Applied Research ◽  
Bridging Studies

There have been numerous exhortations for more ‘translational research’. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscience findings that might be relevant for translation, and then by a discussion of the challenges and opportunities in relation to mental disorders. The time-frame for the pathway from science findings to health benefits is usually long, and generally requires an interactive interplay among different scientific strategies. There is a false dichotomy between so-called basic and applied research and translation needs to proceed from the bedside to the laboratory as well as in the opposite direction. There is a key need for bridging research of the hypothesis-testing experimental medicine variety. Health benefits may involve either public health considerations or the treatment of individual patients, or both. There are now some opportunities for direct translational research but there is a much greater need for hypothesis-based bridging studies that occupy a crucial mid-phase in the pathway from science findings to health benefits.

Clinical application of protein biomarkers in lupus erythematosus and lupus nephritis

Lupus ◽  
2018 ◽  
Vol 27 (10) ◽  
pp. 1582-1590 ◽  
Author(s):  
S Qi ◽  
Q Chen ◽  
D Xu ◽  
N Xie ◽  
Y Dai
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Clinical Applications ◽  
Protein Biomarkers ◽  
Systemic Lupus ◽  
Multiple Organs ◽  
Cytokines And Chemokines ◽  
Clinical Differential Diagnosis ◽  
Circulating Autoantibodies ◽  
New Protein

Systemic lupus erythematosus (SLE) is a type of autoimmune disease that damages multiple organs, including the heart, joints, liver and kidneys. The main characteristics of SLE are the deposition of circulating autoantibodies; autoantigen complexes in the renal system; and abnormal expression of complements, cytokines and chemokines. Lupus nephritis (LN) is the most serious manifestation of SLE and is characterized by inflammation of the kidney. This review summarizes recent clinical applications of protein biomarkers including autoantibodies, complements, cytokines and chemokines and some new protein biomarkers in SLE and LN. The clinical differential diagnosis of protein biomarkers related to prognosis and diagnosis is discussed and highlighted. Protein biomarkers play crucial roles in the study of SLE and LN. Useful biomarkers will provide insights into effective treatments for these diseases.

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