Molecularly Imprinted Polymer Particles and Beads: A Survey of Modern Synthetic Techniques

2020 ◽  
Vol 16 ◽  
Author(s):  
Nasrullah Shah ◽  
Zubair Ullah Khan ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Stationary Phases ◽  
Special Focus ◽  
Specific Function ◽  
Separation And Purification ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Technology ◽  
Shape And Size

Abstract: Molecular imprinting technology is based on incorporating template molecules in the polymer matrix followed by their extraction to leave specific cavities similar in shape and size to the incorporated template molecules. The resultant molecularly imprinted polymers (MIPs) then show antibody-like and enzyme-like behavior. MIPs are used as selective adsorbents, stationary phases, sensors, drug delivery agents, ultrafiltration systems and as catalysts etc. To achieve a specific function, MIPs are synthesized in various forms like beads, particles, membranes, fibers and composites. MIP beads and particles have prime importance due to their use in multiple applications. In this article, we present a survey of various polymerization techniques used for the synthesis of MIP beads and particles along with special focus on the studies presenting their use in separation and purification

scholarly journals Selective Recognition of Gallic Acid Using Hollow Magnetic Molecularly Imprinted Polymers with Double Imprinting Surfaces

Polymers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 175
Author(s):  
Jiawei Li ◽  
Xinji Zhou ◽  
Yu Yan ◽  
Dianling Shen ◽  
Danqing Lu ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Molecularly Imprinted Polymers ◽  
Response Strength ◽  
Separation And Purification ◽  
Complex Matrix ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Better Than

Gallic acid is widely used in the field of food and medicine due to its diversified bioactivities. The extraction method with higher specificity and efficiency is the key to separate and purify gallic acid from complex biological matrix. Herein, using self-made core-shell magnetic molecularly imprinted polymers (MMIP) with gallic acid as template, a hollow magnetic molecularly imprinted polymer (HMMIP) with double imprinting/adsorption surfaces was prepared by etching the mesoporous silica intermediate layer of MMIP. The characterization and adsorption research showed that the HMMIP had larger specific surface area, higher magnetic response strength and a more stable structure, and the selectivity and saturated adsorption capacity (2.815 mmol/g at 318 K) of gallic acid on HMMIP were better than those of MMIP. Thus, in addition to MMIP, the improved HMMIP had excellent separation and purification ability to selectively extract gallic acid from complex matrix with higher specificity and efficiency.

Recent developments in molecularly imprinted polymer nanofibers and their applications

2015 ◽  
Vol 7 (18) ◽  
pp. 7406-7415 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Imprinted Polymer ◽  
Polymer Nanofibers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recent Developments ◽  
Analyte Detection

Molecularly imprinted polymers (MIPs) have been potential and versatile candidates for analyte detection.

Simple and selective detection of quercetin in extracts of plants and food samples by dispersive-micro-solid phase extraction based on core–shell magnetic molecularly imprinted polymers

2018 ◽  
Vol 42 (19) ◽  
pp. 16144-16153 ◽  
Author(s):  
Arash Asfaram ◽  
Maryam Arabi ◽  
Abbas Ostovan ◽  
Hossein Sadeghi ◽  
Mehrorang Ghaedi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Food Samples ◽  
Selective Detection ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymer ◽  
Magnetic Molecularly Imprinted Polymers

In the present study, a D-μ-SPE clean-up method was established for the analysis of quercetin in extracts of plants and food samples using a magnetic molecularly imprinted polymer as the sorbent by HPLC-UV detection.

Quercetin Molecularly Imprinted Polymers and its Application in the Separation and Analysis of Natural Products

2015 ◽  
Vol 1083 ◽  
pp. 46-50
Author(s):  
Rui Mei Liu ◽  
Lai Gui ◽  
Shi Feng Dai ◽  
Yan Ju Zhang ◽  
Zhi Gang Xu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Selective Extraction ◽  
Medicinal Herbs ◽  
Chinese Medicinal Herbs ◽  
Separation And Purification ◽  
Preparation Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Extraction And Purification ◽  
Effective Components

Molecularly imprinted polymers could selectively adsorb the target analytes from complex matrix. Chinese medicinal herbs had the characteristics of multi-component contents and complicated matrix. Molecularly imprinted polymers were very suitable for the selective extraction and purification of effective components in Chinese medicinal herbs. In this paper, the preparation methods of quercetin molecularly imprinted polymers and its applications in the separation and analysis of Chinese medicinal herbs were comprehensively reported. It would be a good reference for the selective separation and purification of quercetin in Chinese medicinal herbs.

scholarly journals Determination of sialic acid in serum samples by dispersive solid-phase extraction based on boronate-affinity magnetic hollow molecularly imprinted polymer sorbent

RSC Advances ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 5394-5401 ◽  
Author(s):  
Wei Huang ◽  
Xingyu Hou ◽  
Yukui Tong ◽  
Miaomiao Tian
Keyword(s):  
Sialic Acid ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Phase Extraction ◽  
Dispersive Solid Phase Extraction ◽  
Imprinted Polymer ◽  
Serum Samples ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Boronate-affinity magnetic hollow molecularly imprinted polymers were prepared with sialic acid (SA) as a template to selectively extract SA from serum samples coupled with HPLC-UV.

scholarly journals Reusable molecularly imprinted polymeric nanospheres for diclofenac removal from water samples

2020 ◽  
pp. 174751982092599
Author(s):  
Noha Amaly ◽  
Georges Istamboulie ◽  
Ahmed Y El-Moghazy ◽  
Thierry Noguer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Residue Removal ◽  
Pharmaceutical Pollutants ◽  
Polymer Nanospheres ◽  
Average Size

The preparation of efficient molecularly imprinted polymers materials (MIPs) for pharmaceutical residue removal is still a challenging task. Herein, we design uniformly molecularly imprinted polymer nanospheres via a precipitation polymerization method using methacrylic acid (MAA) as functional monomer and N,N-methylenebis(acrylamide) (MBAA) as a crosslinker for removal of diclofenac (DFC) as a model for pharmaceutical pollutants. Nanospheres with average size 200 nm were prepared with MAA:MBAA at a ratio of 1:7 and acetonitrile/toluene (1:1) as a porogenic solvent. The successful synthesis is evidenced by Fourier transform infrared spectroscopy, scanning electron microscopy, and with a particle size analyzer. The rebinding experiments confirmed that the more introduction of the carboxyl groups from MAA could remarkably improve the imprinting effect with a significantly increased imprinting factor and specific rebinding capacity reached 450 mg/g after 15 min. Furthermore, the adsorption capacity of the molecularly imprinted polymers is maintained above 85% after seven regeneration cycles, indicating that the molecularly imprinted polymers can be used multiple times. Moreover, the developed molecularly imprinted polymers show promising DFC removal efficiency from real water samples, which suggests that the prepared molecularly imprinted polymer nanospheres are promising in DFC separation.

scholarly journals MOLECULARLY IMPRINTED POLYMER NANOPARTICLES (MIP-NPs) APPLICATIONS IN ELECTROCHEMICAL SENSORS

2019 ◽  
pp. 1-6
Author(s):  
DIANE FAUZI ◽  
FEBRINA AMELIA SAPUTRI
Keyword(s):  
Molecularly Imprinted Polymers ◽  
High Stability ◽  
Electrochemical Sensors ◽  
Specific Binding ◽  
Environmental Contaminants ◽  
Polymer Nanoparticles ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Molecularly Imprinted Polymers (MIPs) is a polymer that binds together to form a specific binding site that is selective for certain analytes. Its high stability, its synthesize simplicity, and it can ease costs significantly make it was applied widely as a receptor instead of antibodies or enzymes. MIPs can be re-developed into MIPs nanoparticles (MIP-NPs) which have greater potential. MIPs use in electrochemical sensors have relevant applications in daily life and have been tested in human samples. Electrochemical sensors have been successfully functioned with MIP-NPs leading to real-time monitoring of drugs, pesticides, environmental contaminants, and secondary metabolites, as well as molecules with biological relevance. The aim of this review is to summarize the developments and applications of MIP-NPs as a selective recognition component in electrochemical sensors with special emphasis on their analytical applications.

Molecularly Imprinted Polymer and Computational Study of (E)-4-(2- cyano-3-(dimethylamino)acryloyl)benzoic Acid from Poly(ethylene terephthalate) Plastic Waste

2020 ◽  
Vol 16 (2) ◽  
pp. 119-137 ◽  
Author(s):  
Asmaa M. Fahim ◽  
Bartłomiej Wasiniak ◽  
Jerzy P. Łukaszewicz
Keyword(s):  
Benzoic Acid ◽  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Ethylene Terephthalate ◽  
Computational Study ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene

Background: Molecularly imprinted polymers (MIPs) are utilized in the separation of a pure compound from complex matrices. A stable template-monomer complex generates MIPs with the highest affinity and selectivity for the template. In this investigation, degradation of Poly(ethylene terephthalate) PET afforded the (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (4) (TAM) which used TAM as template which interacts with Methacrylic Acid (MAA) monomer, in the presence of CH3CN as progen. The TAM-MMA complex interactions are dependent on stable hydrogen bonding interaction between the carboxylic acid group of TAM and the hydroxyl group of MMA with minimal interference of porogen CH3CN. The DFT/B3LYP/6-31+G model chemistry was used to optimize their structures and frequency calculations. The binding energies between TAM with different monomers showed the most stable molar ratio of 1:4 which was confirmed through experimental analysis. Methods: The present work describes the synthesis of (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (4) (TAM) from PET waste and formation of molecularly imprinted polymer from TAM with the methacrylic acid monomer. The optimization of molecular imprinted was stimulated via DFT/B3LYP/6-31G (d). The imprinted polymer film was characterized via thermal analysis, pore size, FT-IR and scanning electron microscopy. Results: The most stable molecularly imprinted polymers (MIPs) showed binding energy of TAM(MMA4)=-2063.456 KJ/mol with a small value of mesopores (10-100 Å). Also, the sorption capability of TAM-MIPs showed 6.57 mg/g using STP-MIP-9VC. Moreover, the average pore size ranged between 0.2-1 nm with the BET surface about 300 m2/g. Conclusion: The proposed TAM exhibited a high degree of selectivity for MMA in comparison with other different monomers through hydrogen bond interaction, which was thermally stable, good reproducibility and excellent regeneration capacity and elucidated in the computational study and analytical analysis.

Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol

2004 ◽  
Vol 57 (8) ◽  
pp. 759 ◽  
Author(s):  
Lachlan Schwarz ◽  
Clovia I. Holdsworth ◽  
Adam McCluskey ◽  
Michael C. Bowyer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Competitive Binding ◽  
Imprinted Polymer ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Molecule ◽  
High Preference ◽  
Structural Analogues

Molecularly imprinted polymers (MIPs) selective for the phenolic contaminant 2,4,6-trichlorophenol (2,4,6-TCP) were prepared and evaluated in three porogens of differing character (hexane, acetonitrile, dichloromethane). Rebinding of 2,4,6-TCP was found to be most effective in dichloromethane (imprinting factor: 13.2). Competitive binding studies performed against a range of close structural analogues showed a high preference for the target molecule, although partial recognition towards 2,4-dichlorophenol was also observed. Specificity was found to be dependent upon the presence of ring chlorine on the target, which suggested that these atoms participate in secondary binding interactions that are essential for successful recognition in the polymer cavity.

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