A Systematic Review on Preclinical and Clinical Studies on the Use of Scaffolds for Bone Repair in Skeletal Defects

BackgroundOver the past 10 years the technique of tryptophan depletion has been used increasingly as a tool for studying brain serotonergic systems.AimsTo review the technique of tryptophan depletion and its current status as a tool for investigating psychiatric disorders.MethodSystematic review of preclinical and clinical studies.ResultsTryptophan depletion produces a marked reduction in plasma tryptophan and consequently brain serotonin (5-HT) synthesis and release. In healthy volunteers the effects of tryptophan depletion are influenced by the characteristics of the subjects and include some mood lowering, some memory impairment and an increase in aggression. In patients with depression tryptophan depletion tends to result in no worsening of depression in untreated subjects but a relapse in those who have responded to antidepressants (particularly serotonergic agents). In panic disorder the results are similar.ConclusionsThe findings that tryptophan depletion produces a relapse of symptoms in patients with depression and panic disorder who have responded to treatment with antidepressants suggests that enhanced 5-HT function is important in maintaining response in these conditions.

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Tissue Engineering of the Urethra: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies

European Urology ◽

10.1016/j.eururo.2017.03.026 ◽

2017 ◽

Vol 72 (4) ◽

pp. 594-606 ◽

Cited By ~ 32

Author(s):

Luuk R.M. Versteegden ◽

Paul K.J.D. de Jonge ◽

Joanna IntHout ◽

Toin H. van Kuppevelt ◽

Egbert Oosterwijk ◽

...

Keyword(s):

Systematic Review ◽

Tissue Engineering ◽

Clinical Studies ◽

Meta Analysis ◽

Preclinical And Clinical Studies

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Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis

Stem Cell Research & Therapy ◽

10.1186/s13287-021-02632-y ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Hector Lafuente ◽

Ibon Jaunarena ◽

Eukene Ansuategui ◽

Arantza Lekuona ◽

Ander Izeta

Keyword(s):

Systematic Review ◽

Clinical Studies ◽

Meta Analysis ◽

Cell Types ◽

Lymphatic Drainage ◽

Secondary Lymphedema ◽

Disease Outcomes ◽

Underlying Mechanisms ◽

Preclinical And Clinical Studies ◽

Positive Effect

Abstract Background Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in secondary lymphedema, but no meta-analysis has been performed to assess their efficacy. Methods We conducted a systematic review and meta-analysis of all available preclinical and clinical studies, with assessment of their quality and risk of bias. Results A total of 20 articles using diverse cell types were selected for analysis, including six clinical trials and 14 pre-clinical studies in three species. The meta-analysis showed a positive effect of cell-based therapies on relevant disease outcomes (quantification of edema, density of lymphatic capillaries, evaluation of the lymphatic flow, and tissue fibrosis). No significant publication bias was observed. Conclusion Cell-based therapies have the potential to improve secondary lymphedema. The underlying mechanisms remain unclear. Due to relevant heterogeneity between studies, further randomized controlled and blinded studies are required to substantiate the use of these novel therapies in clinical practice.

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