scholarly journals Tryptophan depletion and its implications for psychiatry

2001 ◽  
Vol 178 (5) ◽  
pp. 399-405 ◽  
Author(s):  
Caroline Bell ◽  
Jolane Abrams ◽  
David Nutt
Keyword(s):  
Systematic Review ◽  
Panic Disorder ◽  
Clinical Studies ◽  
Memory Impairment ◽  
Marked Reduction ◽  
Current Status ◽  
Tryptophan Depletion ◽  
Plasma Tryptophan ◽  
The Past ◽  
Preclinical And Clinical Studies

BackgroundOver the past 10 years the technique of tryptophan depletion has been used increasingly as a tool for studying brain serotonergic systems.AimsTo review the technique of tryptophan depletion and its current status as a tool for investigating psychiatric disorders.MethodSystematic review of preclinical and clinical studies.ResultsTryptophan depletion produces a marked reduction in plasma tryptophan and consequently brain serotonin (5-HT) synthesis and release. In healthy volunteers the effects of tryptophan depletion are influenced by the characteristics of the subjects and include some mood lowering, some memory impairment and an increase in aggression. In patients with depression tryptophan depletion tends to result in no worsening of depression in untreated subjects but a relapse in those who have responded to antidepressants (particularly serotonergic agents). In panic disorder the results are similar.ConclusionsThe findings that tryptophan depletion produces a relapse of symptoms in patients with depression and panic disorder who have responded to treatment with antidepressants suggests that enhanced 5-HT function is important in maintaining response in these conditions.

scholarly journals Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis

2020 ◽  
Vol 19 ◽  
pp. 153473542095944
Author(s):  
Jing Guo ◽  
Lixia Pei ◽  
Lu Chen ◽  
Hao Chen ◽  
Dongmei Gu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Acupuncture Therapy ◽  
Supportive Care ◽  
Bibliometric Analysis ◽  
Integrative Medicine ◽  
Clinical Studies ◽  
Current Status ◽  
Cancer Center ◽  
Future Research ◽  
The Past

Purpose: Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the current status and trends in this field over the past 2 decades. Methods: Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was used for co-authorship network of countries/institutions, dual-map analysis, and detecting the keywords with citation bursts. VOSviewer was used to construct networks based on co-authorship and co-citation analysis of authors, and co-occurrence of keywords. Results: A total of 927 articles and reviews were included in the final analysis. The number of publications has steadily increased with some fluctuations among years. The country and institution contributing most to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was the most productive author and Molassiotis A ranked first in the cited authors. The co-occurrence analysis revealed 5 clusters (including “clinical trials,” “clinical studies on chemotherapy/radiation-induced symptoms,” “CAM therapy for cancer,” “clinical studies on vasomotor symptoms,” and “systematic reviews”). Most recent keyword bursts were “neuropathic pain,” “arthralgia,” “prevention,” “supportive care,” and “integrative medicine”. Conclusions: The annual publication output would increase rapidly in the next decade, which shows a promising future in this research field. Future research hotspots would focus on the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive care, and integrative medicine.

scholarly journals Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience

2019 ◽  
Vol 2019 ◽  
pp. 1-31 ◽  
Author(s):  
Cem Simsek ◽  
Ece Esin ◽  
Suayib Yalcin
Keyword(s):  
Clinical Studies ◽  
Lower Cost ◽  
Metronomic Chemotherapy ◽  
Maximum Tolerated Dose ◽  
Cancer Management ◽  
The Past ◽  
Promising Therapeutic Approach ◽  
Treatment Models ◽  
Dose Dense ◽  
Preclinical And Clinical Studies

Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts’ immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies. The evidence of metronomic chemotherapy for personalized medicine is growing, starting with unfit elderly patients and also for palliative treatment. The literature reviewed in this article mainly demonstrates that metronomic chemotherapy is advantageous for selected patients and for certain types of malignancies, which make it a promising therapeutic approach for filling in the gaps. More clinical studies are needed to establish a solidified role for metronomic chemotherapy with other treatment models in modern cancer management.

Tissue Engineering of the Urethra: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies

2017 ◽  
Vol 72 (4) ◽  
pp. 594-606 ◽  
Author(s):  
Luuk R.M. Versteegden ◽  
Paul K.J.D. de Jonge ◽  
Joanna IntHout ◽  
Toin H. van Kuppevelt ◽  
Egbert Oosterwijk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tissue Engineering ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Preclinical And Clinical Studies

scholarly journals Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hector Lafuente ◽  
Ibon Jaunarena ◽  
Eukene Ansuategui ◽  
Arantza Lekuona ◽  
Ander Izeta
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Cell Types ◽  
Lymphatic Drainage ◽  
Secondary Lymphedema ◽  
Disease Outcomes ◽  
Underlying Mechanisms ◽  
Preclinical And Clinical Studies ◽  
Positive Effect

Abstract Background Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in secondary lymphedema, but no meta-analysis has been performed to assess their efficacy. Methods We conducted a systematic review and meta-analysis of all available preclinical and clinical studies, with assessment of their quality and risk of bias. Results A total of 20 articles using diverse cell types were selected for analysis, including six clinical trials and 14 pre-clinical studies in three species. The meta-analysis showed a positive effect of cell-based therapies on relevant disease outcomes (quantification of edema, density of lymphatic capillaries, evaluation of the lymphatic flow, and tissue fibrosis). No significant publication bias was observed. Conclusion Cell-based therapies have the potential to improve secondary lymphedema. The underlying mechanisms remain unclear. Due to relevant heterogeneity between studies, further randomized controlled and blinded studies are required to substantiate the use of these novel therapies in clinical practice.

Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies

2020 ◽  
Vol 53 ◽  
pp. 101339 ◽  
Author(s):  
Anastasia S. Suraev ◽  
Nathaniel S. Marshall ◽  
Ryan Vandrey ◽  
Danielle McCartney ◽  
Melissa J. Benson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sleep Disorders ◽  
Clinical Studies ◽  
Preclinical And Clinical Studies

Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies

2021 ◽  
pp. canres.1258.2021
Author(s):  
Lin Yang ◽  
Andria R. Morielli ◽  
Emily Heer ◽  
Amy A. Kirkham ◽  
Winson Y. Cheung ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Treatment ◽  
Treatment Efficacy ◽  
Clinical Studies ◽  
Preclinical And Clinical Studies
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