The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide’s Toxicity

Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL.

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Network pharmacology-based analysis of the mechanisms of Tripterygium wilfordii Hook F on cardiovascular disease

10.22541/au.160133689.94946588 ◽

2020 ◽

Author(s):

Bingwu Huang ◽

Chengbin Huang ◽

Liuyan Zhu ◽

Lina Xie ◽

Yi Wang ◽

...

Keyword(s):

Cardiovascular Disease ◽

Network Pharmacology ◽

Tripterygium Wilfordii ◽

Tripterygium Wilfordii Hook F ◽

Tripterygium Wilfordii Hook

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Exploring the Pharmacological Mechanisms of Tripterygium Wilfordii Hook F against Cardiovascular Disease Using Network Pharmacology and Molecular Docking

10.21203/rs.3.rs-151905/v1 ◽

2021 ◽

Author(s):

Bingwu Huang ◽

Chengbin Huang ◽

Liuyan Zhu ◽

Lina Xie ◽

Yi Wang ◽

...

Keyword(s):

Cardiovascular Disease ◽

Drug Targets ◽

R Package ◽

Mitogen Activated Protein Kinase ◽

Network Pharmacology ◽

P Value ◽

Tripterygium Wilfordii ◽

Tripterygium Wilfordii Hook F ◽

The Core ◽

Tripterygium Wilfordii Hook

Abstract Background Tripterygium wilfordii Hook F (TwHF) has been used in traditional Chinese medicines (TCM) for treating cardiovascular disease (CVD). However, the underlying pharmacological mechanisms of the effects of TwHF against CVD remain elusive. This study revealed the pharmacological mechanisms of TwHF acting on CVD based on a pharmacology approach. Materials and Methods The active compounds were selected by Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) according to the absorption, distribution, metabolism, and excretion (ADME). The potential targets of TwHF were obtained by SwissTargetPrediction database. The CVD-related therapeutic targets were collected by the DrugBank, the GeneCards database and the OMIM database. Protein–protein interaction (PPI) network was generated by STITCH database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed by R package. The network of drug-targets-diseases-pathways was constructed by Cytoscape software. Results The 51 effective ingredients of TwHF and the 178 common targets of TwHF and CVD-related were collected. Furthermore, AKT1, amyloid precursor protein (APP), Mitogen-activated protein kinase 1 (MAPK), phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) and cellular tumor antigen p53 (TP53) was identified the core targets involved in the mechanism of TwHF on CVD. Top ten GO (biological processes, cellular components and molecular functions) and KEGG pathways were screened with a P value ≤ 0.01. Finally, we constructed the network of TwHF-targets-CVD-GO-KEGG. Conclusions These findings demonstrate that the main active compound of TwHF, the core targets and pathways maybe provide new insights into the development of a natural therapy for the prevention and treatment of CVD.

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The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review

Frontiers in Medicine ◽

10.3389/fmed.2021.747922 ◽

2021 ◽

Vol 8 ◽

Author(s):

Peng Liu ◽

Jing Zhang ◽

Yun Wang ◽

Zhengri Shen ◽

Chen Wang ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Molecular Mechanisms ◽

Tripterygium Wilfordii ◽

Active Compounds ◽

Tripterygium Wilfordii Hook F ◽

Traditional Chinese Herbal Medicine ◽

Tripterygium Wilfordii Hook ◽

Systematic Understanding

Tripterygium wilfordii Hook. f. (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol are predominantly active compounds isolated from TWHF. The effects and molecular mechanisms of TWHF and its active compounds have been investigated in recent years. Currently, it is becoming clearer that the effects of TWHF and its active compounds involve in anti-inflammation, anti-oxidative stress, anti-fibrosis, regulating autophagy, apoptosis, and protecting podocytes effect. This review presents an overview of the current findings related to the effects and mechanisms of TWHF and its active compounds in therapies of DN, thus providing a systematic understanding of the mechanisms and therapeutic targets by which TWHF and its active compounds affect cells and tissues in vitro and in vivo.

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Exploring the Pharmacological Mechanisms of Tripterygium wilfordii Hook F against Cardiovascular Disease Using Network Pharmacology and Molecular Docking

BioMed Research International ◽

10.1155/2021/5575621 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Bingwu Huang ◽

Chengbin Huang ◽

Liuyan Zhu ◽

Lina Xie ◽

Yi Wang ◽

...

Keyword(s):

Cardiovascular Disease ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Drug Targets ◽

Mitogen Activated Protein Kinase ◽

Network Pharmacology ◽

Tripterygium Wilfordii ◽

Tripterygium Wilfordii Hook F ◽

The Core ◽

Tripterygium Wilfordii Hook

Background. Tripterygium wilfordii Hook F (TwHF) has been used in traditional Chinese medicine (TCM) for treating cardiovascular disease (CVD). However, the underlying pharmacological mechanisms of the effects of TwHF on CVD remain elusive. This study revealed the pharmacological mechanisms of TwHF acting on CVD based on a pharmacology approach. Materials and Methods. The active compounds were selected from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database according to the absorption, distribution, metabolism, and excretion (ADME). The potential targets of TwHF were obtained from the SwissTargetPrediction database. The CVD-related therapeutic targets were collected from the DrugBank, the GeneCards database, and the OMIM database. Protein–protein interaction (PPI) network was generated by the STITCH database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed by R package. The network of drug-targets-diseases-pathways was constructed by the Cytoscape software. Results. The 41 effective ingredients of TwHF and the 178 common targets of TwHF and CVD-related were collected. Furthermore, AKT1, amyloid precursor protein (APP), mitogen-activated protein kinase 1 (MAPK), phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA), and cellular tumor antigen p53 (TP53) were identified as the core targets involved in the mechanism of TwHF on CVD. Top ten GO (biological processes, cellular components, and molecular functions) and KEGG pathways were screened with a P value ≤0.01. Finally, we constructed the network of TwHF-targets-CVD-GO-KEGG. Conclusions. These findings demonstrate that the main active compound of TwHF, the core targets, and pathways maybe provide new insights into the development of a natural therapy for the prevention and treatment of CVD.

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