Anti-cancer Research on Arnebiae Radix-derived Naphthoquinone in Recent Five Years

Background: In recent years, many naphthoquinone compounds with anticancer activity have been identified in Arnebiae Radix, and some of them have the potential to be developed into anticancer drugs. Objective: This article aimed to provide a comprehensive overview of the anticancer effects of naphthoquinone compounds through a detailed review of literature and Chinese patents, and discuss their potential to be developed as anticancer drugs for clinical application. Methods: Research papers were collected through the databases of PubMed, Cnki and SciDirect using keyword searches “naphthoquinone compounds” and “anticancer”. The keywords of “shikonin” and “shikonin derivatives” were also used in PubMed, Cnki and SciDirect databases to collect research articles. The Chinese patents were collected using the Cnki patent database. Results: Naphthoquinone compounds have been found to possess anti-cancer activity, and their modes of action are associated with inducing apoptosis, inhibiting cancer cell proliferation, promoting autophagy in cancer cells, anti-cancer angiogenesis and inhibition of cell adhesion, invasion and metastasis, inhibiting glycolysis and inhibiting DNA topoisomerase activity. Conclusion: Most of the naphthoquinone compounds show effective anti-cancer activity in vitro. The structure modification of naphthoquinone aims to develop anti-cancer drugs with high efficacy and low toxicity.

Download Full-text

Anti-cancer activity of quercetin, gallic acid, and ellagic acid against hepg2 and hct 116 cell lines: in vitro

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2016.7.4.b584-592 ◽

2016 ◽

Vol 7 (4) ◽

Cited By ~ 1

Author(s):

AHMED ABD-RABOU A ◽

AZIZA SHALBY B ◽

HANAA AHMED H

Keyword(s):

Gallic Acid ◽

Cell Lines ◽

Ellagic Acid ◽

Anti Cancer ◽

Hct 116 ◽

Cancer Activity

Download Full-text

Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro

3 Biotech ◽

10.1007/s13205-020-02570-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Anuradha Barigela ◽

Bhima Bhukya

Keyword(s):

Pediococcus Acidilactici ◽

Gut Inflammation ◽

Anti Cancer ◽

Cancer Activity

Download Full-text

Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév.

RSC Advances ◽

10.1039/c6ra26361e ◽

2017 ◽

Vol 7 (6) ◽

pp. 3408-3412 ◽

Cited By ~ 11

Author(s):

Long Ma ◽

Haiyan Liu ◽

Lingpei Meng ◽

Ping Qin ◽

Botao Zhang ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Anti Cancer ◽

Saponin Fraction ◽

Cancer Activity

Triterpenoidal saponins fraction isolated from a traditional Chinese medicine Conyza blinii H. Lév. demonstrates anti-cancer activity both in vitro and in vivo.

Download Full-text

Design and synthesis of novel benzimidazoles containing 1,2,3-triazolesas in vitro, anticancer and anti-oxidant agents

Research Journal of Chemistry and Environment ◽

10.25303/2511rjce104109 ◽

2021 ◽

Vol 25 (11) ◽

pp. 104-109

Author(s):

Gullapelli Kumaraswamy ◽

Ravichandar Maroju ◽

Srinivas Bandari ◽

Gouthami Dasari ◽

Gullapelli Sadanandam

Keyword(s):

Spectroscopic Methods ◽

Moderate Activity ◽

Design And Synthesis ◽

Anti Cancer ◽

Excellent Activity ◽

Test Organisms ◽

Anti Oxidant ◽

High Yields ◽

Cancer Activity

A novel series of 2-(1-((1-substitutedphenyl-1H-1,2,3- triazol-4-yl)methoxy)ethyl)-1-((1-substituted phenyl- 1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazole (3a-j)derivatives was synthesized in moderate to high yields. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopic methods. The title compounds were screened for their anti-oxidant activity and anti-cancer activity. The cancer activity results reveal that the compounds 3j, 3b and 3f are showing promising activity and remaining compounds exhibited moderate activity against all the tested cancer cell lines. The anti-oxidant activity also shows that the compounds 3c and 3d have shown excellent activity and remaining compounds were also found to exhibit moderate activity against the test organisms employed.

Download Full-text

Synthesis, Electronic Structure and Anti-Cancer Activity of the Phenyl Substituted Pyrazolo[1,5-a][1,3,5]triazines

Current Organic Chemistry ◽

10.2174/1385272825666210607004536 ◽

2021 ◽

Vol 25 ◽

Author(s):

Evgenia S. Veligina ◽

Nataliya V. Obernikhina ◽

Stepan G. Pilyo ◽

Oleksiy D. Kachkovsky ◽

Volodymyr S. Brovarets

Keyword(s):

Electronic Transition ◽

Lone Electron Pair ◽

Electron Pair ◽

Anti Cancer ◽

Protein Molecules ◽

Biological Affinity ◽

Cancer Types ◽

Derivatives Of ◽

Cancer Activity

: Background: Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5- a][1,3,5]triazines was carried out and evaluated in vitro for their anticancer activity against a panel of 60 cell lines derived from nine cancer types. The joint quantum-chemical and experimental study of the influence of the extended πconjugated phenyl substituents on the electron structure of the pyrazolo[1,5-a][1,3,5]triazines as Pharmacophores were performed. It is shown that the decrease in the barriers to the rotation of phenyl substituents in compounds 1-7 possibly leads to an increase in the anti-cancer activity, which is in agreement with the change in the parameter biological affinity ϕ0. Analysis of the S0 → S1 electronic transitions (π→π*) of the pyrazolo[1,5-a][1,3,5]triazines shows that an increase in their intensity correlates with anti-cancer activity. Thus, the introduction of phenyl substituents increases the likelihood of investigated pyrazolo[1,5-a][1,3,5]triazines interacting with protein molecules (Biomolecule) by the π stacking mechanism. In both methyl and phenyl derivatives of pyrazolo[1,5-a][1,3,5]triazines, the second electronic transition includes the n-MO (the level of the lone electron pair in two-coordinated nitrogen atoms). The highest intensity of the η→π* electronic transition is observed in pyrazolo[1,5-a][1,3,5]triazine with pyridine residue, which does not exhibit anti-cancer activity, but exhibits antiviral activity [13]. It can be assumed that the possibility of the formation of [Pharmacophore-Biomolecule] complex by hydrogen bonding ([H-B]) mechanism with protein molecules increases.

Download Full-text