The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran

Background: Dyslipidemia is recognized as an important factor in the incidence of Preterm Birth (PTB). The early diagnosis of factors affecting PTB is important in the reduction of maternalneonatal complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB in women from the Guilan province of Iran. Method: The current investigation was a prospective cohort study on 378 pregnant women in Rasht city (Guilan province), during 2018-2019. Samples were randomly selected among pregnant women who referred to Al-Zahra hospital. Association of the lipid profiles: Total Cholesterol (TC), High- Density Lipoprotein (HDLC), Low-Density Lipoprotein (LDLC), and Triglycerides (TG) with PTB was assessed using the Chi-square, Fisher tests and logistic regression analysis. Results: Our findings showed that of the evaluated lipid profiles, TG and TC had the highest predictive power with AUC =0.833 (95٪, CI: 0.736-0.930) and 0.772 (95%, CI: 0.676-0.867), respectively; also, their sensitivity and specificity were 83.3%, 70.2% and 83.3%, 66.1%, respectively. Moreover, abnormal LDL concentrations increase the risk of PTB by two folds (P < 0.05). Conclusion: It seems that by controlling the lipid profiles of pregnant women, the risk of PTB could be reduced.

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Uterocervical angle measurement for preterm birth prediction in singleton pregnant women with no history of preterm birth and normal cervical length: A prospective cohort study

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2020.06.020 ◽

2020 ◽

Vol 252 ◽

pp. 30-35

Author(s):

Rapphon Sawaddisan ◽

Ounjai Kor-anantakul ◽

Ninlapa Pruksanusak ◽

Alan Geater

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Pregnant Women ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cervical Length ◽

Angle Measurement ◽

History Of

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Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study

BMJ ◽

10.1136/bmj.n422 ◽

2021 ◽

pp. n422

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Specific Mortality

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Low density lipoprotein cholesterol is associated with increased risk of cardiovascular disease in participants over 70 years old: a prospective cohort study

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2021.10.009 ◽

2021 ◽

Author(s):

Xin Su ◽

Deqiang Zheng ◽

Meiping Wang ◽

Yingting Zuo ◽

Jing Wen ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Increased Risk

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Diabetes mellitus, but not small dense low-density lipoprotein, is predictive of cardiovascular disease: A Korean community-based prospective cohort study

Journal of Diabetes Investigation ◽

10.1111/jdi.12091 ◽

2013 ◽

Vol 4 (6) ◽

pp. 546-551 ◽

Cited By ~ 4

Author(s):

Sunghwan Suh ◽

Hyung-Doo Park ◽

Sang-Man Jin ◽

Hye Jeong Kim ◽

Ji Cheol Bae ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Disease ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Community Based

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Predictive Value of Second-Trimester Maternal Lipid Profiling in Early-Onset Pre-eclampsia: A Prospective Cohort Study and Nomogram

Frontiers in Medicine ◽

10.3389/fmed.2021.688312 ◽

2021 ◽

Vol 8 ◽

Author(s):

Juan Li ◽

Juefei Lu ◽

Mengni Wang ◽

Wen Hu ◽

Neng Jin ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Lipid Profile ◽

Prospective Cohort Study ◽

Predictive Value ◽

Early Onset ◽

Prospective Cohort ◽

Density Lipoprotein ◽

Second Trimester ◽

Lipid Profiling

Purpose: Maternal lipid profile in second trimester has rarely been investigated in the risk assessment for pre-eclampsia (PE). Since early-onset PE often companied by much worse clinical outcomes, thus, we aimed to evaluate the predictive value of second-trimester maternal lipid profiling for early-onset PE.Methods: A prospective cohort study was conducted to measure the second-trimester maternal lipid profile of pregnant women from January to December 2019. The pairwise association between maternal lipid profile and PE onset or pregnancy termination time was quantified. Multiple logistic regression was preformed to define risk factors for early-onset PE, and a nomogram for early-onset PE was developed. The net benefit of our model was evaluated by calibration curve and decision curve analyses.Results: We enrolled 5,908 pregnant women and they were divided into healthy (n = 5,789), late-onset PE (n = 64), and early-onset PE (n = 55) groups. Total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) were elevated in patients with PE, while high-density lipoprotein cholesterol (HDL-c) was decreased in patients with PE. TC, TG, and LDL-c were negatively correlated with PE onset time or gestational week at delivery. Receiver operating characteristic curves (ROC) defined the cutoff values of TG and HDL-c, and the final regression model included five statistically significant risk predictors for early-onset PE (maternal age of ≥35 years, multipara, pre-pregnancy body mass index (BMI) ≥25 kg/m2, second trimester TG ≥ 2.59 mmol/L and second trimester HDL-c ≤ 2.03 mmol/L. The nomogram had an excellent diagnostic performance (area under the curve = 0.912, sensitivity = 92.7%, and specificity = 76%) and was further validated with good calibration and positive net benefits in a decision curve analysis.Conclusions: An abnormally increased TG concentration and a decreased HDL-c concentration might serve as predictors of early-onset PE. Whether blood lipid-lowering measures can improve severe PE prognosis require further clarification.

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