Variation in the Level of Thyroid Markers in Association with Inflammation in Patients with Type 2 Diabetes

2020 ◽  
Vol 20 (6) ◽  
pp. 924-929
Author(s):  
Khalid Siddiqui ◽  
Teena P. George ◽  
Salini Scaria Joy ◽  
Muhammad Mujammami
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Thyroid Hormones ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Tnf Α

Background: A possible relationship between thyroid hormones and glucose metabolism in diabetes has already been established. Objectives: We aimed to evaluate the thyroid function markers and their relationship with inflammation, which is considered as a pathogenic condition of diabetes. Methods: This cross-sectional study included 276 patients with type 2 diabetes. Serum levels of thyroid (TSH, FT4, and FT3) and inflammatory markers (CRP, IL-6, and TNF-α) were measured. Results: The mean age of the subjects was 55.2 years and mean diabetes duration of 16.8 years. The inflammatory markers showed significant differences with the tertiles of TSH and thyroid hormones. TSH was significantly correlated with inflammatory markers, IL-6 (r = 0.13, P = 0.020) and TNF-α (r = 0.17, P = 0.003), while FT4 had a correlation only with TNF-α (r = 0.25, P = <0.001). FT3 was negatively correlated with inflammatory marker IL-6 (r = -0.14, P = 0.020), HbA1c (r = -0.12, P = 0 .040), and HOMA-IR (r = -0.17, P = 0.010). Conclusion: Abnormalities in the thyroid hormone metabolism are related to the increased inflammatory activity as well as insulin resistance, and are associated with the disorders of glucose metabolism.

scholarly journals Lipid Profile Abnormalities in Bangladeshi Type 2 Diabetic Patients Attending a Tertiary Care Hospital: A Cross-Sectional Study

2019 ◽  
Vol 7 (1) ◽  
pp. 44-47
Author(s):  
Afsana Begum ◽  
SM Rezaul Irfan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Impaired lipid profile is commonly present in type 2 diabetes. We aimed to research serum lipid profile abnormalities hypothesizing that early detection and treatment of lipid abnormalitiescan minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM).A total 105patients with T2DM of age within the range of 30-45 years were selected& their Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycatedhaemoglobin (HbA1c) levels were evaluated. Significantly higher mean serum levels of TC, TG and LDL and significantly lower mean serum levels of HDL were noted in patients with diabetes . Significant correlations were observed between HbA1c value and serum levels of TC, TG and HDL (p<0.05) but no correlation of HbA1c value withlow density lipoprotein in diabetes patient.The study showed widespread lipid abnormalities in the course of diabetes triggered dyslipidemia as hypercholesterolemia, hypertriglyceridemia, elevated LDL and decreased HDL. Bangladesh Crit Care J March 2019; 7(1): 44-47

Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

2010 ◽  
Vol 5 (4) ◽  
pp. 421-426 ◽  
Author(s):  
Ines Cilenšek ◽  
Amela Hercegovac ◽  
Rifet Terzić ◽  
Mojca Petrovič ◽  
Daniel Petrovič
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Interleukin 8 ◽  
Sectional Study ◽  
Interleukin 18 ◽  
Cross Sectional

AbstractWe evaluated possible roles of interleukin-8 gene polymorphisms (1633T/C-rs2227543, 251A/T-rs4073) and interleukin-18 gene polymorphisms (-607C/A-rs1946518, -137G/C-rs187238) in the development of diabetic retinopathy (DR) in Caucasians with type 2 diabetes. 271 patients with DR and 113 without diabetic retinopathy were enrolled in this cross-sectional study. We did not observe an association between either interleukin-8 gene polymorphisms (1633T/C, 251A/T) or interleukin-18 gene polymorphisms (-607C/A, -137G/C) and diabetic retinopathy in Caucasians with type 2 diabetes. We did not find statistically significant differences in interleukin-8 serum levels between diabetics with the TT and AA genotype and those with other genotypes. The interleukin-18 serum levels between diabetics with the CC genotype of the -607C/A polymorphism and those with other genotypes (AA, AC) were not significantly different. Moreover, we did not observe a statistically significant effect of the tested polymorphisms of either interleukin-8 or interleukin-18 genes on serum levels in diabetics. In conclusion, our study indicates that the examined polymorphisms of interleukin-8 (1633T/C, 251A/T) and interleukin-18 (-607C/A or the -137G/C) genes are not genetic risk factors for diabetic retinopathy. Therefore, they may not be used as genetic markers for diabetic retinopathy in Caucasians with type 2 diabetes.

scholarly journals A Cross-sectional Study of Serum Levels of Zinc, Copper and Magnesium in Type 2 Diabetes Mellitus in South Indian Urban Population

2021 ◽  
Author(s):  
HU Hemanth Gowda ◽  
Harish Rangareddy
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Zinc ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Insulin Metabolism ◽  
Type 2 Dm

Introduction: Variability in the levels of these trace elements may reflect altered insulin metabolism and poor glycaemic control in the background of elevated oxidative stress. Mineral metabolism is another entity that may be disrupted by diabetes mellitus. Conversely, there are studies implicating early imbalances of trace elements in upsetting glucose homeostasis and insulin metabolism. Aim: To estimate and compare serum zinc, copper and magnesium in Type 2 Diabetes Mellitus (DM) patients with non diabetic controls and to correlate the serum zinc, copper and magnesium with Glycated Haemoglobin levels in Type 2 DM. Materials and Methods: This cross-sectional study was conducted at the Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India. The study included 30 Type 2 DM patients and 30 healthy, age and gender matched controls without Type 2 DM. Their serum levels of zinc, copper and magnesium were measured and compared. Statistical Package for the Social Sciences (SPSS) version 16 software was used to perform the statistical analysis. The data obtained was subjected to descriptive statistical analysis. Results: Mean±SD of serum zinc in Type 2 DM and controls was 93.44±46.99 μg/dL and 121.74±37.15 μg/dL, respectively. Serum zinc was significantly decreased in Type 2 DM. However, there was no significant alteration with respect to serum copper and magnesium. Pearson’s correlation analysis showed that the association between HbA1c with zinc (r=0.069, p=0.718), copper (r= -0.094, p=0.622) and magnesium (r=0.116, p=0.543) was random. Conclusion: Zinc deficiency noticed in Type 2 DM patients may be due to increased excretion in urine. Zinc oral preparations are cheap and easily available. Considering these, it can be further explored if micronutrient supplementation would help to improve the glycaemic variability in Type 2 DM.

scholarly journals DIFFERENCES OF VITAMIN D LEVELS IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETES MELLITUS ( DM ) PATIENTS

2019 ◽  
Vol 26 (1) ◽  
pp. 18
Author(s):  
Adhisti Adhisti Azlin ◽  
Ratna Akbari Ganie ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Dm Type 2

Vitamin D as an immunomodulator, plays an important role in controlling glycemic levels and decreasing diabetes complications. HbA1c is a marker of glycemic control which is known to have association with vitamin D. This study aims to see the differences in vitamin D serum levels and glycemic index in patients with type 2 DM.The design of this study is cross-sectional study and it was performed in RSUP HAM in December 2017 until March 2018. DM type 2 patients were classified based on HbA1c <7% controlled and ≥ 7% uncontrolled. Vitamin D serum levels were examined using the Enzyme-Linked Fluourescent Assay (ELFA) method., differences in vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were assessed by using independent t-test, and the differences of HbA1c level were assessed using Mann-Whitney-U test.45 patients with type 2 DM were divided into controlled (HbA1c <7%) and uncontrolled patients (HbA1c ≥ 7%). There was no difference in vitamin D serum levels between controlled and uncontrolled DM Type 2 patients (p = 0,310).

Large-Scale Cross-Sectional Study of the Problem Areas in Diabetes Survey among Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2393-PUB
Author(s):  
KENICHIRO TAKAHASHI ◽  
MINORI SHINODA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
TADASHI YAMAKAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Large Scale ◽  
Japanese Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetes Survey
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