scholarly journals A Cross-sectional Study of Serum Levels of Zinc, Copper and Magnesium in Type 2 Diabetes Mellitus in South Indian Urban Population

Author(s):  
HU Hemanth Gowda ◽  
Harish Rangareddy

Introduction: Variability in the levels of these trace elements may reflect altered insulin metabolism and poor glycaemic control in the background of elevated oxidative stress. Mineral metabolism is another entity that may be disrupted by diabetes mellitus. Conversely, there are studies implicating early imbalances of trace elements in upsetting glucose homeostasis and insulin metabolism. Aim: To estimate and compare serum zinc, copper and magnesium in Type 2 Diabetes Mellitus (DM) patients with non diabetic controls and to correlate the serum zinc, copper and magnesium with Glycated Haemoglobin levels in Type 2 DM. Materials and Methods: This cross-sectional study was conducted at the Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India. The study included 30 Type 2 DM patients and 30 healthy, age and gender matched controls without Type 2 DM. Their serum levels of zinc, copper and magnesium were measured and compared. Statistical Package for the Social Sciences (SPSS) version 16 software was used to perform the statistical analysis. The data obtained was subjected to descriptive statistical analysis. Results: Mean±SD of serum zinc in Type 2 DM and controls was 93.44±46.99 μg/dL and 121.74±37.15 μg/dL, respectively. Serum zinc was significantly decreased in Type 2 DM. However, there was no significant alteration with respect to serum copper and magnesium. Pearson’s correlation analysis showed that the association between HbA1c with zinc (r=0.069, p=0.718), copper (r= -0.094, p=0.622) and magnesium (r=0.116, p=0.543) was random. Conclusion: Zinc deficiency noticed in Type 2 DM patients may be due to increased excretion in urine. Zinc oral preparations are cheap and easily available. Considering these, it can be further explored if micronutrient supplementation would help to improve the glycaemic variability in Type 2 DM.




2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Alessandra Teixeira Neto Zucatti ◽  
Tatiana Pedroso de Paula ◽  
Luciana Verçoza Viana ◽  
Rafael DallAgnol ◽  
Felipe Vogt Cureau ◽  
...  

The aim of this study is to evaluate the association between usual physical activity and 24 h blood pressure (BP) profile in people with type 2 diabetes mellitus (DM). This is a cross-sectional study of 151 participants with type 2 DM. Usual physical activity was assessed by step counting and self-reported questionnaire. BP was measured in office and by 24 h ambulatory BP monitoring (ABPM; 24 h, daytime and nighttime). Mean participant age was 61.1 ± 8.4 years, 64% was women, and mean duration of diabetes was 14.3 ± 8.5 years. Ninety-two percent of participants had hypertension, and office BP was 138 ± 18/78 ± 10 mmHg. Inverse correlations were observed between step count and 24 h BP (systolic, r=−0.186; p=0.022), daytime BP (systolic, r=−0.198; p=0.015), and nighttime BP (pulse pressure, r=−0.190; p=0.019). People were categorized into tertiles of daily step count, and the 1st tertile had higher 24 h systolic BP, daytime systolic BP, daytime mean BP, and daytime systolic BP load than those in the other tertiles, even after adjusting for age and HbA1c. Participants with type 2 DM and low levels of physical activity exhibit higher 24 h and daytime systolic ambulatory BP values as compared with those who performed more steps per day, even after adjustments for confounding factors.



2021 ◽  
Vol 67 (6) ◽  
pp. 417-423
Author(s):  
Sadako MATSUI ◽  
Chika HIRAISHI ◽  
Ryo SATO ◽  
Takai KOJIMA ◽  
Kiyotaka ANDO ◽  
...  


2019 ◽  
Vol 7 (1) ◽  
pp. 44-47
Author(s):  
Afsana Begum ◽  
SM Rezaul Irfan

Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Impaired lipid profile is commonly present in type 2 diabetes. We aimed to research serum lipid profile abnormalities hypothesizing that early detection and treatment of lipid abnormalitiescan minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM).A total 105patients with T2DM of age within the range of 30-45 years were selected& their Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycatedhaemoglobin (HbA1c) levels were evaluated. Significantly higher mean serum levels of TC, TG and LDL and significantly lower mean serum levels of HDL were noted in patients with diabetes . Significant correlations were observed between HbA1c value and serum levels of TC, TG and HDL (p<0.05) but no correlation of HbA1c value withlow density lipoprotein in diabetes patient.The study showed widespread lipid abnormalities in the course of diabetes triggered dyslipidemia as hypercholesterolemia, hypertriglyceridemia, elevated LDL and decreased HDL. Bangladesh Crit Care J March 2019; 7(1): 44-47



2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Victor Mogre ◽  
Robert Abedandi ◽  
Zenabankara S. Salifu

Type 2 diabetes mellitus (type 2 DM) has become a disease of public health concern worldwide. Obesity and elevated blood pressure have been shown to be comorbidities of type 2 DM. In this cross-sectional study in Tamale, Ghana, we determined the prevalence of abdominal obesity among type 2 DM patients. Furthermore, we examined the demographic, clinical, and anthropometric predictors of increasing waist circumference in this population. Three hundred type 2 DM patients attending the outpatient diabetes clinic of the Tamale Teaching Hospital, Ghana, were recruited for the study. Waist circumference (WC) and hip circumferences were measured appropriately. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) and fasting plasma glucose (FPG) were taken from the personal health record files of patients. Demographic data were obtained. Pearson correlation and multiple linear regression models were employed to identify predictors of increasing WC. The prevalence of abdominal obesity was 77.0% and was significantly higher in women than in men. A positive correlation was observed between waist-to-hip ratio (WHR) and WC (r=0.56, P<0.001), female gender (r=0.73, P<0.001), and age (r=0.20, P<0.001). A high prevalence of abdominal obesity was observed. Predictors of increasing WC were gender, age, FPG, and WHR.



Author(s):  
Rofana Aghniya ◽  
◽  
Bhisma Murti ◽  
Didik Gunawan Tamtomo ◽  
Hanung Prasetya ◽  
...  

Background: The prevalence of depression is two to three times higher in diabetic patients, while most cases remain undiagnosed. The quality of life is substantially and adversely affected by depression. This study aimed to estimate the effect of depression comorbidity on patients’ quality of life with type 2 diabetes mellitus. Subjects and Method: This was a meta-analysis and systematic review. The study was conducted by collecting published articles from PubMed, ProQuest, Science Direct, Scopus, Spinger Link, Clinical Key, and Google Scholar databases. Keywords used “comorbidity depression and DM”, “depression and quality of life and DM and cross sectional study”, “depression and quality of life and DM and adjusted odd ratio”, “depression or diabetes”, “depression or quality of life or DM or adjusted odd ratio”. The study criteria were full text, using cross-sectional study design, and reporting adjusted Odds Ratio (aOR). The selected articles were analyzed using Revman 5.3 with fixed effect models. Results: 8 studies from Uganda, Iran, United States, United Kingdom, Australia, Nigeria, Brazil, and Nepal, were selected for this study. Current study reported that type 2 DM patients with depression had lower quality of life than those without depression (aOR= 2.72; 95% CI= 0.73 to 10.07; p<0.0001) Conclusion: Type 2 DM patient with depression has lower quality of life than those without depression. Keywords: depression, quality of life, diabetes mellitus Correspondence: Rofana Aghniya. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +685523528340.



Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2393-PUB
Author(s):  
KENICHIRO TAKAHASHI ◽  
MINORI SHINODA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
TADASHI YAMAKAWA ◽  
...  


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 910-P
Author(s):  
YO KOHATA ◽  
MAKOTO OHARA ◽  
TOMOKI FUJIKAWA ◽  
HIROE NAGAIKE ◽  
HIDEKI KUSHIMA ◽  
...  


2021 ◽  
Vol 10 ◽  
pp. 100703
Author(s):  
Ajoy Tiwari ◽  
Dinesh Kumar ◽  
Mohammad S. Ansari ◽  
Santosh Kumar Chaubey ◽  
Nitin R. Gupta ◽  
...  


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