scholarly journals Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets

2020 ◽  
Vol 14 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Yen N.T. Dang ◽  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Controlled Drug Release ◽  
Milling Process ◽  
Wet Granulation ◽  
Natural Material ◽  
Drug Bioavailability ◽  
Disintegration Time ◽  
Ocimum Gratissimum ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Wetting Time

Background: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. Objective: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). Methods: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tablets, such as weight variation, hardness, friability, wetting time, disintegration time, drug content, and dissolution studies, was performed. Results: The modification of OGS using the swelling/ milling process resulted in a completion of OGS modification, leading to an ideal wetting time, disintegrating time, and dissolution rate. The OGS concentrations also affected the wetting and disintegrating time with the optimal range of ODTs from 15% to 20%. On the other hand, the modification with the incubation processes varied by temperature and time increased the wetting time and disintegrating time. Conclusions: The modified OGS demonstrated that it is a potential material with the advantages of cost-effectiveness, non-toxicity and easy manufacture in the preparation of ODTs.

scholarly journals Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets

2020 ◽  
Vol 13 (5) ◽  
pp. 100
Author(s):  
Blasco Alejandro ◽  
Torrado Guillermo ◽  
Peña M Ángeles
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
Biomedical Sciences ◽  
Disintegration Time ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Percentage Of Water Absorption ◽  
Hostile Environments

This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.

Studies on Orally Disintegrating Tablets Prepared by Using Natural and Synthetic Superdisintegrants

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Piplani Mona ◽  
Diwedi Rohini ◽  
Bhagwat Deepak Prabhakar ◽  
Pahwa Rakesh
Keyword(s):  
Direct Compression ◽  
Dissolution Test ◽  
Plantago Ovata ◽  
Compression Technique ◽  
Disintegration Time ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Metoclopramide Hydrochloride ◽  
Wetting Time ◽  
Croscarmellose Sodium

The objective of present study was to compare the disintegration efficiency of mucilage isolated from Plantago ovata with commonly used synthetic superdisintegrant, croscarmellose sodium in the formulation of orally disintegrating tablets. Effects of varying concentration of both superdisintegrants on disintegration time were studied. Orally disintegrating tablets of metoclopramide hydrochloride were prepared using selected superdisintegrants by direct compression technique. Prepared tablets were evaluated for weight variation, thickness, hardness, friability, disintegration time, wetting time, water absorption ratio and dissolution test. Swelling index was also investigated for comparing the swelling property of croscarmellose sodium with mucilage of Plantago ovata. Swelling index of mucilage isolated from Plantago ovata was found to be greater (94 ± 2.5% v/v) when compared with croscarmellose sodium (85 ± 1.5% v/v). The present study indicated that mucilage isolated from natural source proved to be more effective for their disintegrating property than the most commonly used synthetic superdisintegrant, croscarmellose sodium.

scholarly journals COMPARATIVE STUDY OF SUPERDISINTEGRANTS USING ANTIEMETIC DRUG AS A MODEL

2015 ◽  
Vol 05 (01) ◽  
pp. 040-044
Author(s):  
D S Sandeep ◽  
R Narayana Charyulu ◽  
Prashant Nayak
Keyword(s):  
Drug Release ◽  
Antiemetic Drug ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Model Drug

AbstractIn the present investigation comparison of three different superdisintegrants was carried out by formulating orally disintegrating tablets. Promethazine HCl was used as model drug which is an antiemetic drug. Sodium starch glycolate, croscarmellose and crospovidone were selected as superdisintegrants and each one was used in three different concentrations (2%, 3.5% and 5%). The drug-polymer compatibility was ruled out by FTIR studies. A total of nine formulations (PF1-PF9) were made by direct compression. All prepared formulations were evaluated for weight variation, hardness, friability, drug content, disintegration time, wetting time and in vitro drug release parameters. The results of the evaluation parameters for all the nine formulations of promethazine HCl were within the standard limits. The in vitro drug release for promethazine HCl tablets of all the formulations (PF1-PF9) was carried out using phosphate buffer pH 6.8 as dissolution medium. Among all the formulations the tablets formulated with crospovidone (PF7-PF9) have shown 91.43 - 98.43% (maximum) drug release at the end of 10 min than sodium starch glycolate and croscarmellose, hence from the present work, it concluded that among three superdisintegrants crospovidone is the ideal superdisintegrant for formulating oral disintegrating tablets for promethazine HCl.

scholarly journals Design, Formulation and Physicochemical Evaluation of Dimenhydrinate Orally Disintegrating Tablets

2018 ◽  
Vol 7 ◽  
pp. e936
Author(s):  
Abolfazl Aslani ◽  
Alireza Ghasemi ◽  
Shekofeh Karbasizadeh Esfahani
Keyword(s):  
Proper Time ◽  
Angle Of Repose ◽  
Content Uniformity ◽  
Disintegration Time ◽  
Design Expert ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Physicochemical Evaluation ◽  
Wetting Time ◽  
Group 2

Background: Design, formulation and physicochemical evaluation of dimenhydrinate 25 mg oral tablets that disintegrate in oral cavity in a proper time. This product is easy to use for babies, geriatrics and people who have difficulty in swallowing. Materials and Methods: 31 formulations were designed in 3 categories via Design-Expert software version 7. Group 1 consist of super-disintegrating bases, group 2 consist of effervescent bases and group 3 consist of super-disintegrating and effervescent bases together. Proposed by Design-Expert software, the optimum formulations were selected in each category and the tablets were produced by direct compression method. Tablets evaluated by friability, thickness, hardness, weight variation, drug content, content uniformity, disintegration time, wetting time, dissolution and moisture uptake tests. Results: The angle of repose and compressibility index of formulations were in the range of 24.65-29.08 and 5.02-9.01 % respectively. Thickness, hardness, wetting time, friability and content uniformity of formulations were in the range of 3.36-3.84 mm, 33.25-38.03 N, 19-37 seconds, 0.31-0.42 % and 96.44-99.02 % respectively. Disintegration time of the groups 1, 2 and 3 were in the range of 16-70, 47-72 and 12-35 seconds, respectively. Conclusion: Mixture of powders and orally dispersible tablets passed all tests. The results showed that formulations containing both of super-disintegrants and effervescent bases had better disintegration time compare to other formulations. [GMJ.2018;7:e936]

scholarly journals Arabinoxylan from Plantago ovate (Husk) a novel binder and superdisintegrant

2015 ◽  
Vol 13 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Alia Erum ◽  
Sajid Bashir ◽  
Shazia Saghir ◽  
Rai Muhammad Sarfraz
Keyword(s):  
Water Absorption ◽  
Good Alternative ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Pharmaceutical Industries ◽  
Wetting Time

The aim of the present investigation was to evaluate the binding and disintegrating properties of arabinoxylan isolated from Ispaghula (Plantago ovata) husk. Atenolol and atorvastatin orodispersible tablet F1, F2 and F3 were prepared by direct compression method using arabinoxylan (12, 9, 6) mg as superdisintegrant, and F4 and F5 containing 12 mg Ispaghula husk and 12 mg sodium starch glycolate, respectively. Metformin tablets were prepared by wet granulation method F1 containing starch as binder, F2 containing arabinoxylan as binder and F3 containing arabinoxylan as binder and as superdisintegrant. Prepared tablets were evaluated for precompression parameters such as compatibility studies, bulk density, tapped density, angle of repose, Hausners ratio and Cars index and post compression parameters such as weight variation, hardness, thickness, diameter, wetting time, water absorption ratio disintegration time drug release and moisture uptake studies. Attempts were done to trace the possible disintegrant mechanism of arabinoxylan. FTIR spectra of physical blend of atenolol, atorvastatin, metformin with arabinoxylan confirmed the compatibility of excepient with formulation ingredients. All the formulations of atenolol, atorvastatin satisfied the limits of redispersion with a dispersion time of less than 60 sec. F1 showed minimum disintegration time 4 sec providing the evidence of arabinoxylan an excellent superdisintegrant when compared with F4 containing Ispaghula husk with disintegration time 30 sec and F5 contains sodium starch glycolate having disintegration time of 35 sec. Minimum wetting time of 17 sec and high water absorption ratio of F1 formulation confirmed the arabinoxylan as swelling disintegrant. The results of metformin tablet indicate that arabinoxylan could be useful to produce tablets with desired characteristics for specific purposes, and could be used as an alternative substitute binder and superdisintegrant in pharmaceutical industries. These studies provide a strong evidence for usefulness of arabinoxylan as binder and superdisintegrant and a good alternative to natural and synthetic superdisintegrant. DOI: http://dx.doi.org/10.3329/dujps.v13i2.21891 Dhaka Univ. J. Pharm. Sci. 13(2): 133-141, 2014 (December)

scholarly journals FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PALIPERIDONE

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Kaushikbhai Ghanshyambhai Gajera ◽  
Anil G Raval
Keyword(s):  
Disintegration Time ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Two Factors ◽  
Tablet Properties ◽  
Wetting Time ◽  
Full Factorial ◽  
In Vitro Disintegration ◽  
Pvp K30

Optimized orally disintegrating tablets (ODTs) containing Paliperidone were prepared by direct compression method. Two factors, three levels (32) full factorial design was used to optimize the effect of superdisintegrant (crospovidone; X1) and; Binder (PVP K30S; X2) on tablet properties. The prepared ODTs were characterized for their drug content, hardness, friability and wetting time. The optimized ODT formulation (P4) was evaluated in term of in vitro disintegration and dissolution. The manufactured ODTs were complying with the pharmacopeia guidelines regarding hardness, friability, weight variation and content. PVP K30 had a very slightly enhancing effect on tablets disintegration. However, the effects of both Crospovidone (X1) and PVP K30 (X2) on ODTs drug release (Y1) were significant (p < 0.05). Moreover, X1 exhibited significant effect on the disintegration time. Furthermore, the optimized ODTs formula showed 1 month stability, and in vitro disintegration time of this formula was about 33 s. Key Words: Paliperidone, orally disintegrating tablets

Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Suresh Kulkarni ◽  
Ranjit P. ◽  
Nikunj Patel ◽  
Someshwara B. ◽  
Ramesh B. ◽  
...  
Keyword(s):  
Water Absorption ◽  
In Vitro Dissolution ◽  
Thickness Variation ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Fast Disintegrating Tablets ◽  
Cox 1

The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Meloxicam is a newer selective COX-1 inhibitor. The tablets were prepared by wet granulation procedure. The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec. Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium. The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.

Formulation and Evaluation of Baclofen Orally Disintegrating Tablets

1970 ◽  
Vol 2 (4) ◽  
pp. 733-738
Author(s):  
Dumpeti Janardhan ◽  
Joginapally Sreekanth ◽  
P.Theja Pavan Kumar ◽  
M.Vamshi Krishna
Keyword(s):  
Pilot Scale ◽  
Taste Masking ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Disintegration Time ◽  
Granulation Process ◽  
Good Taste ◽  
Orally Disintegrating Tablets ◽  
Human Volunteers ◽  
Eudragit Epo

The purpose of this study was to evaluate the potential of polymers for masking the taste of bitter drugs when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (baclofen) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. The optimal granulation process parameters were polymer selection and its concentration (w/w), suitable for pilot scale level. Dextrates, β- cyclodextrin, eudragit EPO and PVP K-30 were used in preparation of granules by using water and iso-propyl alcohol. Crospovidone was used intra and extra granularly as superdisintegrant.  Sodium bicarbonate and citric acid were used as effervescent for fast disintegration of tablets, which also optionally act as desensitizer of taste buds. Results from evaluation of tablets indicated a disintegration time (avg) of 30-35 sec and 100% drug release was achieved within 5 min. But taste masking was achieved by only with eudragit EPO. Results from an evaluation by a panel of six human volunteers demonstrated that the orally disintegrating tablets which are prepared by using polymer Eudragit EPO (5% and 7.5% w/w of tablet) and PVP (7.5% w/w of tablet) improved taste, significantly. On studying physical parameters, F9 formulation demonstrated acceptable level of hardness and friability with good taste masking and it was thus considered as an optimized formulation

Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablets for Treatment of Hypertension

2014 ◽  
Vol 7 (2) ◽  
pp. 2450-2458
Author(s):  
Sarika Pundir ◽  
Ashutosh Badola
Keyword(s):  
Kinetic Studies ◽  
Film Coating ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Simultaneous Estimation ◽  
Matrix Tablet ◽  
Release Agent ◽  
Disintegration Time ◽  
Weight Variation

In the present study we have formulated (F1 to F6) matrix tablets of atenolol and indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinized starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated for weight variation, hardness, friability, drug content, disintegration time and in vitro drug release using USP dissolution apparatus type 2 (paddle). It was found that the optimized formulation showed 49.33%, 48.90%, 48.52%, 47.65%, 46.84% and 46.51% release for atenolol in 12 hours respectively. However, indapamide released 49.62%, 49.39%, 48.72%, 48.27%, 47.59% and 47.36% at the end of 12 hr. The IR spectrum study revealed that there is no disturbance in the principal peaks of pure drugs atenolol and indapamide. This confirms the integrity of pure drugs and no incompatibility of them with excipients. The stability studies were carried out for the optimized batch for one months and it showed satisfactory results. The kinetic studies of the formulations revealed that diffusion is the predominant mechanism of drug and release follows Zero-order, Super case II transport.

Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine

2015 ◽  
Vol 8 (2) ◽  
pp. 2881-2888
Author(s):  
Sudarshan Singh ◽  
S S Shyale ◽  
P Karade
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Drug Content ◽  
Weight Variation ◽  
Wetting Time ◽  
Croscarmellose Sodium

The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmellose sodium by sublimating agent such as camphor. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies. The prepared tablets were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry. The disintegration time for the complexed tablets prepared by different concentration of superdisintegrants was found to be in range of 32.54 ± 0.50 to 55.12 ± 0.57 sec and wetting time of the formulations was found to be in range of 28.47 ± 0.67 to 52.19 ± 0.72 sec. All the formulation showed almost 100 percent of drug release within 15 min. Among all the formulation F6 and F7 prepared with 18% croscarmellose sodium and camphor shows faster drug release, respectively 10 min, F6 gives good result for disintegration time, drug release, wetting time and friability. Further formulations were subjected to stability testing for 30 days at temperature of 40 ± 5 ºC/75 ± 5 %RH. Tablets showed no appreciable changes with respect to physical appearance, drug content, disintegration time and dissolution profiles. Results were statistically analyzed by one-way ANOVA at a p < 0.05. It was found that, the data at any point of time are significant at p < 0.05.

Sign in / Sign up

Export Citation Format

Share Document