scholarly journals Arabinoxylan from Plantago ovate (Husk) a novel binder and superdisintegrant

2015 ◽  
Vol 13 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Alia Erum ◽  
Sajid Bashir ◽  
Shazia Saghir ◽  
Rai Muhammad Sarfraz
Keyword(s):  
Water Absorption ◽  
Good Alternative ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Pharmaceutical Industries ◽  
Wetting Time

The aim of the present investigation was to evaluate the binding and disintegrating properties of arabinoxylan isolated from Ispaghula (Plantago ovata) husk. Atenolol and atorvastatin orodispersible tablet F1, F2 and F3 were prepared by direct compression method using arabinoxylan (12, 9, 6) mg as superdisintegrant, and F4 and F5 containing 12 mg Ispaghula husk and 12 mg sodium starch glycolate, respectively. Metformin tablets were prepared by wet granulation method F1 containing starch as binder, F2 containing arabinoxylan as binder and F3 containing arabinoxylan as binder and as superdisintegrant. Prepared tablets were evaluated for precompression parameters such as compatibility studies, bulk density, tapped density, angle of repose, Hausners ratio and Cars index and post compression parameters such as weight variation, hardness, thickness, diameter, wetting time, water absorption ratio disintegration time drug release and moisture uptake studies. Attempts were done to trace the possible disintegrant mechanism of arabinoxylan. FTIR spectra of physical blend of atenolol, atorvastatin, metformin with arabinoxylan confirmed the compatibility of excepient with formulation ingredients. All the formulations of atenolol, atorvastatin satisfied the limits of redispersion with a dispersion time of less than 60 sec. F1 showed minimum disintegration time 4 sec providing the evidence of arabinoxylan an excellent superdisintegrant when compared with F4 containing Ispaghula husk with disintegration time 30 sec and F5 contains sodium starch glycolate having disintegration time of 35 sec. Minimum wetting time of 17 sec and high water absorption ratio of F1 formulation confirmed the arabinoxylan as swelling disintegrant. The results of metformin tablet indicate that arabinoxylan could be useful to produce tablets with desired characteristics for specific purposes, and could be used as an alternative substitute binder and superdisintegrant in pharmaceutical industries. These studies provide a strong evidence for usefulness of arabinoxylan as binder and superdisintegrant and a good alternative to natural and synthetic superdisintegrant. DOI: http://dx.doi.org/10.3329/dujps.v13i2.21891 Dhaka Univ. J. Pharm. Sci. 13(2): 133-141, 2014 (December)

Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Suresh Kulkarni ◽  
Ranjit P. ◽  
Nikunj Patel ◽  
Someshwara B. ◽  
Ramesh B. ◽  
...  
Keyword(s):  
Water Absorption ◽  
In Vitro Dissolution ◽  
Thickness Variation ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Fast Disintegrating Tablets ◽  
Cox 1

The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Meloxicam is a newer selective COX-1 inhibitor. The tablets were prepared by wet granulation procedure. The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec. Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium. The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.

scholarly journals FORMULATION AND STATISTICAL OPTIMIZATION OF BILAYER SUBLINGUAL TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE

2016 ◽  
Vol 9 (5) ◽  
pp. 228
Author(s):  
Priyanka Choudhury ◽  
Pulak Deb ◽  
Suvakanta Dash
Keyword(s):  
Water Absorption ◽  
Statistical Optimization ◽  
Content Uniformity ◽  
Direct Compression ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Sodium Starch Glycolate ◽  
Wetting Time ◽  
Ambroxol Hydrochloride ◽  
Standard Limit

ABSTRACTObjective: The aim of the present study is to formulate and optimize bilayer sublingual tablets of Levocetrizine hydrochloride and Ambroxolhydrochloride using a 2 response surface methodology employing design expert-10.0. Sodium starch glycolate and Camphor were selected asindependent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. 3Methods: The bilayer sublingual tablets were prepared by direct compression and evaluated for various evaluation parameters including hardness,thickness, friability, drug content uniformity, wetting time, water absorption ratio and disintegration time. The prepared optimized bilayer sublingualtablets of Levocetrizine hydrochloride and Ambroxol hydrochloride having above 2 responses-disintegration time (sec) and water absorption ratio.Results: The optimized batch having concentration of sodium starch glycolate and camphor was found within the standard limit of parametersdisintegrationtime (sec) and waterabsorption ratio(%) as 61 sec and 69.67%.Conclusion: The direct compression method in this study is relatively simple and safe and a stable, effective and pleasant tasting bilayer sublingualtablet, which has a good balance over disintegration time and water absorption ratio, was formulated.Keywords: Levocetirizine hydrochloride, Ambroxol hydrochloride, Croscarmellose sodium, Sodium starch glycolate, Camphor, Statistical optimization.

scholarly journals FORMULATION AND EVALUATION OF FLURBIPROFEN FAST DISINTEGRATING TABLETS USING NATURAL SUPERDISINTEGRANTS

2016 ◽  
Vol 9 (6) ◽  
pp. 247 ◽  
Author(s):  
Mohammed Sarfaraz ◽  
Surendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Disintegration Time ◽  
Natural Sources ◽  
Weight Variation ◽  
Wetting Time ◽  
Tapped Density ◽  
Fast Disintegrating Tablets

ABSTRACTObjective: The main objective of this research was to formulate Fast disintegrating tablets of Flurbiprofen incorporating superdisintegrants, isolated from natural sources like Plantago ovata (PO) seeds, Lepidium sativum (LS) seeds and agar-agar.Methods: Superdisintegrants were isolated from their natural sources using reported methods. Swelling index and hydration capacity was determined for the natural superdisintegrants to know their disintegration capacity. The tablet formulations were designed using isolated natural superdisintegrants. The powder blends were evaluated for pre-compressional parameters like angle of repose, bulk density, tapped density, carr’s index, and hausner’s ratio. Fast disintegrating tablets were prepared by direct compression method. The compressed tablets were characterized for post compression parameters.Results: All formulations had hardness, friability, weight variation and drug content within the pharmacopoeial limits. The wetting time was 84 to 254 sec, in vitro disintegration time was between 59.2 to 221 sec, and in-vitro drug release was as low as 11.80% (LS1) to a maximum of 98.99% (PO4) after 4 min of study. Among all, optimized formulation was PO4, as it showed good wetting time (84 sec), fastest disintegration time (59.2 sec), dispersion time (135 sec) and drug release of 98.99.% within 4 min.Conclusion: Flurbiprofen FDT’s were successfully developed using isolated natural disintegrants. The natural disintegrants isolated showed promising results and can prove as effective alternative for synthetic disintegrants.

scholarly journals Formulation design, optimization & in vitro evaluation of novel orodissolving tablets of efavirenz for hiv infections

2015 ◽  
Vol 49 (3) ◽  
pp. 173-180
Author(s):  
T Ayyappan ◽  
C Poojitha ◽  
T Vetrichelvan
Keyword(s):  
Drug Release ◽  
In Vitro Dissolution ◽  
Dissolution Time ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Wetting Time

In the present work, orodissolving tablets of Efavirenz were prepared by direct compression method with a view to enhance patient compliance. A 23 full factorial design was applied to investigate the combined effect of three formulation variables. Amount of crospovidone, croscarmellose sodium and sodium starch glycolate were used as superdisintegrant material along with direct compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration time, wetting time, drug content and in-vitro dissolution studies. Based on wetting time, disintegration time, the formulation containing crospovidone (5% w/v), carscarmellose sodium (5% w/v) and sodium starch glycolate (8% w/v) was found to be promising and tested for in-vitro drug release pattern (in 0.1 N HCl), short term stability and drug- superdisintegrants interaction. Surface response plots are presented to graphically represent the effect of independent variables (conc. of superdisintegrants) on the in-vitro dissolution time. The validity of the generated mathematical model was tested by preparing extra-design check point formulation. The formulation showed nearly faster drug release compared to the conventional commercial tablet formulation. Stability studies on the optimized formulation indicated that there was no significant change found in physical appearance, hardness, disintegration time, drug content and in-vitro drug release. DOI: http://dx.doi.org/10.3329/bjsir.v49i3.22131 Bangladesh J. Sci. Ind. Res. 49(3), 173-180, 2014

scholarly journals FORMULATION AND CHARACTERIZATION OF HERBAL TABLETS FOR THE MANAGEMENT OF DENGUE

2021 ◽  
pp. 104-113
Author(s):  
Shikha Thakur ◽  
Brisha Bhardwaj ◽  
Shouvik Kumar Nandy
Keyword(s):  
Carica Papaya ◽  
Hardness Test ◽  
Herbal Extract ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Weight Variation ◽  
Phosphorus Iron ◽  
Fresh Pulp ◽  
Tapped Density

Tablets are used as formulation and are prepared by using plant extracts i.e., Carica papaya and Embelica officinalis. These tablets were prepared by using wet granulation method. In this article the extract of leaves of Carica papaya and fruits of Embelica officinalis were used for making herbal tablets. Extracts of leaves of Carica papaya was obtained by cold extraction and through maceration method and the extract of fruits of Embelica officinalis was obtained by maceration process. Both extracts were dried and mixed. These extracts were then impregnated with the excipients like diluents, binding agents, super disintegrating agent, lubricants, etc. to make granules. These granules were then evaluated by using various parameters like Angle of repose, tapped density, bulk density, Carr’s Index, Hausner’s Ratio and void volume. These granules were then used for the making of tablets of desired size and shape by punching in the machine. After preparation of the tablets their evaluation parameters were studied like physical appearance, weight variation, friability, disintegration time, hardness test and thickness. Also the parameters for the acceptance of the tablets is also done like flavor and sweetness. Recent studies have shown that herbal extract of leaves of papaya has beneficial effect as an anti-inflammatory agent, for its wound healing properties, anti-tumor as well as Immunomodulatory effects and as an antioxidant. Amla fruit is a rich natural source of vitamin C (Ascorbic acid) and contains 600-750 mg/100 g of the fresh pulp. Also it is rich in minerals matters like phosphorus, iron and calcium. Amla is used as an Immunomodulatory agent and hence enhance the immunity of the patient. Aim of the study is to design develop and optimize the dosage form to cure dengue and is based on the use of natural plant ingredients to intermingle with chemical as well as synthetic ingredients to develop an effective unit dosage forms for better patient compliance. KEYWORDS: Papaya, Amla, Extracts, Herbal tablet, Dengue, Immunomodulatory, Platelets.

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF CINITAPRIDE HYDROGEN TARTARATE BY USING DIRECT COMPRESSION TECHNIQUE

2017 ◽  
Vol 9 (6) ◽  
pp. 98 ◽  
Author(s):  
Krishna Mohan Chinnala ◽  
Sirish Vodithala
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Bulk Density ◽  
Direct Compression ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Tapped Density ◽  
Fast Disintegrating Tablets

Objective: In the present study, efforts were taken to develop fast disintegrating tablets of Cinitapride hydrogen tartrate, is a gastro-prokinetic agent and antiulcer agent with an objective to achieve rapid disintegration, and further improving the bioavailability of the drug. Also, to resolve the swallowing problems (Dysphasia) in pediatric, geriatric patients by rapid disintegration in saliva and improve the patient compliance.Methods: Fast disintegrating tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG) and combination of super-disintegrants in different concentrations. The prepared formulations were evaluated for the pre-compression parameters like bulk density, tapped density, Carr’s compressibility, Hausner’s ratio and angle of repose. The prepared batches of fast disintegrating tablets of Cinitapride hydrogen tartarate were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time, wetting time, water absorption ratio, and in vitro dissolution profile.Results: Bulk density and tapped density were found in the range of 0.412–0.432 g/cc and 0.507–0.528 g/cc respectively. In all formulations, tablet weight and thickness were within mean±9.5% and mean±5% respectively. Wetting time values lie between 19.76 to 39.53 sec. Water absorption ratio ranged from 57.30 to 78.82 %. The in vitro disintegration time for all the 12 formulations varied from 17.43 to 38.61 seconds. Formulation F8 which contained crosspovidone have recorded drug release 96.94±0.47% at the end of 30 min.Conclusion: The formulation containing crospovidone (F8) showed better performance in terms of disintegration time and drug release when compared to other formulations.

A COMPARATIVE QUALITATIVE STUDY OF DISPERSIBLE TABLETS OF THREE DIFFERENT COMMERCIAL BRANDS

2019 ◽  
Vol 8 (5) ◽  
Author(s):  
Ankita Kishore ◽  
Pradeep Kashyap ◽  
Devender Sharma ◽  
Ranjan Kumar Singh
Keyword(s):  
Acetylsalicylic Acid ◽  
Water Absorption ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Disintegration Time ◽  
Old Patients ◽  
Solid Dosage ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Dispersible Tablets

Dispersible tablets are uncoated or film-coated tablets meant to be spread in water before administration giving a unvaried dispersion. Pediatric and old patients face complications in swallowing the conventional tablets. So according to the need dispersible tablets have been developed which combine the benefits of liquid dosage forms and solid dosage forms. The dispersible tablets allow dispersion in water prior to administration. In present study we have compared three brands of different dispersible tablets. The objective of the study was to find out the best dosage form based on the post compression parameters of dispersible tablets and to develop a co-relation among these parameters. Three brands of dispersible tablets had been selected i.e. Acetylsalicylic acid, Cefixime & Paracetamol tablets and they have been compared on the basis of different parameters of dispersible tablets like uniformity of weight, friability testing, hardness, wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time, uniformity of dispersion. Acetylsalicylic acid & Cefixime complies all the parameters except friability test, while Paracetamol tablets complies all the tests except it was showing more hardness compared to other two brands due to which it’s properties like wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time was lower than other two. So after overall comparison Cefixime was found to be the best in comparison to other two brands. Keywords: Dispersible tablets, paracetamol, cefixime, acetylsalicylic acid, comparison, post compression parameters.

scholarly journals COMPARATIVE STUDY OF SUPERDISINTEGRANTS USING ANTIEMETIC DRUG AS A MODEL

2015 ◽  
Vol 05 (01) ◽  
pp. 040-044
Author(s):  
D S Sandeep ◽  
R Narayana Charyulu ◽  
Prashant Nayak
Keyword(s):  
Drug Release ◽  
Antiemetic Drug ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Model Drug

AbstractIn the present investigation comparison of three different superdisintegrants was carried out by formulating orally disintegrating tablets. Promethazine HCl was used as model drug which is an antiemetic drug. Sodium starch glycolate, croscarmellose and crospovidone were selected as superdisintegrants and each one was used in three different concentrations (2%, 3.5% and 5%). The drug-polymer compatibility was ruled out by FTIR studies. A total of nine formulations (PF1-PF9) were made by direct compression. All prepared formulations were evaluated for weight variation, hardness, friability, drug content, disintegration time, wetting time and in vitro drug release parameters. The results of the evaluation parameters for all the nine formulations of promethazine HCl were within the standard limits. The in vitro drug release for promethazine HCl tablets of all the formulations (PF1-PF9) was carried out using phosphate buffer pH 6.8 as dissolution medium. Among all the formulations the tablets formulated with crospovidone (PF7-PF9) have shown 91.43 - 98.43% (maximum) drug release at the end of 10 min than sodium starch glycolate and croscarmellose, hence from the present work, it concluded that among three superdisintegrants crospovidone is the ideal superdisintegrant for formulating oral disintegrating tablets for promethazine HCl.

scholarly journals Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets

2020 ◽  
Vol 14 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Yen N.T. Dang ◽  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Controlled Drug Release ◽  
Milling Process ◽  
Wet Granulation ◽  
Natural Material ◽  
Drug Bioavailability ◽  
Disintegration Time ◽  
Ocimum Gratissimum ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Wetting Time

Background: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. Objective: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). Methods: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tablets, such as weight variation, hardness, friability, wetting time, disintegration time, drug content, and dissolution studies, was performed. Results: The modification of OGS using the swelling/ milling process resulted in a completion of OGS modification, leading to an ideal wetting time, disintegrating time, and dissolution rate. The OGS concentrations also affected the wetting and disintegrating time with the optimal range of ODTs from 15% to 20%. On the other hand, the modification with the incubation processes varied by temperature and time increased the wetting time and disintegrating time. Conclusions: The modified OGS demonstrated that it is a potential material with the advantages of cost-effectiveness, non-toxicity and easy manufacture in the preparation of ODTs.

scholarly journals Design, Formulation and Physicochemical Evaluation of Dimenhydrinate Orally Disintegrating Tablets

2018 ◽  
Vol 7 ◽  
pp. e936
Author(s):  
Abolfazl Aslani ◽  
Alireza Ghasemi ◽  
Shekofeh Karbasizadeh Esfahani
Keyword(s):  
Proper Time ◽  
Angle Of Repose ◽  
Content Uniformity ◽  
Disintegration Time ◽  
Design Expert ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Physicochemical Evaluation ◽  
Wetting Time ◽  
Group 2

Background: Design, formulation and physicochemical evaluation of dimenhydrinate 25 mg oral tablets that disintegrate in oral cavity in a proper time. This product is easy to use for babies, geriatrics and people who have difficulty in swallowing. Materials and Methods: 31 formulations were designed in 3 categories via Design-Expert software version 7. Group 1 consist of super-disintegrating bases, group 2 consist of effervescent bases and group 3 consist of super-disintegrating and effervescent bases together. Proposed by Design-Expert software, the optimum formulations were selected in each category and the tablets were produced by direct compression method. Tablets evaluated by friability, thickness, hardness, weight variation, drug content, content uniformity, disintegration time, wetting time, dissolution and moisture uptake tests. Results: The angle of repose and compressibility index of formulations were in the range of 24.65-29.08 and 5.02-9.01 % respectively. Thickness, hardness, wetting time, friability and content uniformity of formulations were in the range of 3.36-3.84 mm, 33.25-38.03 N, 19-37 seconds, 0.31-0.42 % and 96.44-99.02 % respectively. Disintegration time of the groups 1, 2 and 3 were in the range of 16-70, 47-72 and 12-35 seconds, respectively. Conclusion: Mixture of powders and orally dispersible tablets passed all tests. The results showed that formulations containing both of super-disintegrants and effervescent bases had better disintegration time compare to other formulations. [GMJ.2018;7:e936]

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