The Impact of the Level of the Intestinal Short Chain Fatty Acids in Inflammatory Bowel Disease Patients Versus Healthy Subjects

Inflammatory bowel disease (IBD) is a complicated disease involving multiple pathogenic factors. The complex relationships between long-chain fatty acids (LCFAs) and the morbidity of IBD drive numerous studies to unravel the underlying mechanisms. A better understanding of the role of LCFAs in IBD will substitute or boost the current IBD therapies, thereby obtaining mucosal healing. In this review, we focused on the roles of LCFAs on the important links of inflammatory regulation in IBD, including in the pathogen recognition phase and in the inflammatory resolving phase, and the effects of LCFAs on immune cells in IBD.

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Wheat Bran Does Not Affect Postprandial Plasma Short-Chain Fatty Acids from 13C-inulin Fermentation in Healthy Subjects

Nutrients ◽

10.3390/nu9010083 ◽

2017 ◽

Vol 9 (1) ◽

pp. 83 ◽

Cited By ~ 6

Author(s):

Lise Deroover ◽

Joran Verspreet ◽

Anja Luypaerts ◽

Greet Vandermeulen ◽

Christophe Courtin ◽

...

Keyword(s):

Fatty Acids ◽

Wheat Bran ◽

Healthy Subjects ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Chain Fatty Acids

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Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts

Microorganisms ◽

10.3390/microorganisms9112216 ◽

2021 ◽

Vol 9 (11) ◽

pp. 2216

Author(s):

Haryung Park ◽

Karina Arellano ◽

Yuri Lee ◽

Subin Yeo ◽

Yosep Ji ◽

...

Keyword(s):

Fatty Acids ◽

Skin Barrier ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Skin Barrier Function ◽

Skin Microbiome ◽

Dry Skin ◽

Pathogen Invasion ◽

The Impact ◽

Chain Fatty Acids

Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and Cutibacterium levels (previously known as Propionibacterium acnes) were significantly higher (p < 0.001) in the moist group. Levels of Cutibacterium were negatively correlated with those of Staphylococcus (p <0.0001) in both dry and moist groups. The moist group also had a significantly higher propionate concentration (p < 0.001). This study showed that the microbial community and short chain fatty acid concentration may be considered as significant determinants of the SCFI of the skin.

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