scholarly journals A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

2018 ◽  
Vol 24 (3) ◽  
pp. 558-572 ◽  
Author(s):  
Pedro Gonçalves ◽  
João Ricardo Araújo ◽  
James P Di Santo
Keyword(s):  
Inflammatory Bowel Disease ◽  
Fatty Acids ◽  
Immune System ◽  
Cross Talk ◽  
Bowel Disease ◽  
Short Chain Fatty Acids ◽  
Mucosal Immune System ◽  
Short Chain ◽  
Intestinal Homeostasis ◽  
Inflammatory Bowel

Dysregulation of Intestinal Mucosal Immunity: Implications in Inflammatory Bowel Disease

Physiology ◽  
2001 ◽  
Vol 16 (6) ◽  
pp. 272-277 ◽  
Author(s):  
F. Stephen Laroux ◽  
Kevin P. Pavlick ◽  
Robert E. Wolf ◽  
Matthew B. Grisham
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune System ◽  
Mucosal Immunity ◽  
Immune Regulation ◽  
Bowel Disease ◽  
Mucosal Immune System ◽  
Gut Inflammation ◽  
Inflammatory Bowel ◽  
Efficient Mechanisms

The mucosal interstitia of the intestine and colon are continuously exposed to large amounts of dietary and microbial antigens. Fortunately, the mucosal immune system has evolved efficient mechanisms to distinguish potentially pathogenic from nonpathological antigens. There are, however, situations in which this immune regulation fails, resulting in chronic gut inflammation.

scholarly journals Sparring partners in inflammatory bowel disease: Resident microbiota and the gastrointestinal mucosal immune system

2011 ◽  
Vol 33 (4) ◽  
pp. 26-31
Author(s):  
Mona Bajaj-Elliott
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Immune System ◽  
Bowel Disease ◽  
Mucosal Immune System ◽  
Inflammatory Conditions ◽  
Cellular Events ◽  
Inflammatory Bowel ◽  
Molecular Nature

Intestinal homoeostasis is a complex affair. We are just beginning to appreciate the molecular nature of the crosstalk that allows happy coexistence between the commensal resident microbiota and the gastrointestinal (GI) mucosal immune system. Both microbial and host components involved in this interplay are being increasingly identified and studied. A better understanding of these multifaceted interactions holds the key for unlocking the cellular events responsible for gut inflammatory conditions such as Crohn's disease and ulcerative colitis.

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