scholarly journals Anti-Nociceptive Effects of Elcatonin Injection for Postmenopausal Women with Back Pain: A Randomized Controlled Trial

2010 ◽  
Vol 4 (1) ◽  
pp. 132-136 ◽  
Author(s):  
Shota Ikegami ◽  
Mikio Kamimura ◽  
Shigeharu Uchiyama ◽  
Hiroyuki Nakagawa ◽  
Hiroyuki Hashidate ◽  
...  

Background: Eel calcitonin (elcatonin) injection is widely used for elderly patients suffering from somatic pain in Japan. However, there have been few reports on the analgesic effects of elcatonin injection. The purpose of this study was to examine the analgesic effects of elcatonin injection in postmenopausal women with lower back pain. Methods: This study was designed as a double-blind, randomized, placebo-controlled study. Thirty-six women aged ≥50 years with acute lower back pain participated in this study. They were randomly divided into two treatment groups according to whether they received a placebo or a weekly trigger point injection of elcatonin (20 units). They were observed for 5 weeks and the extent of pain at motion and at rest according to the visual analog scale (VAS) was evaluated. The mean VAS scores for the elcatonin group were then compared with those of the placebo group. Results: There were no statistically significant differences in the mean VAS scores for pain at rest between the two groups during the 5-week treatment course. However, the mean VAS scores for motion pain in the elcatonin group were significantly lower than those in the placebo group at the third, fifth and sixth weeks. Conclusions: Elcatonin injection (20 units) significantly relieved motion pain in the lower back in postmenopausal women after three weeks of treatment. This analgesic effect continued for the subsequent 3 weeks.

Author(s):  
Matchimamart Chamnankrom ◽  
Nuttaset Manimmanakorn ◽  
Apiwan Manimmanakorn ◽  
Kiattisak Kongwattanakul ◽  
Michael J. Hamlin

BACKGROUND: Low back pain is a common problem in pregnant woman. Elastic tape is an alternative method that may reduce low back pain. OBJECTIVES: To compare the effect of elastic tape to placebo tape in the treatment of low back pain in pregnant women. METHODS: Forty pregnant women were allocated into two groups: elastic group (n= 20) and placebo group (n= 20). All participants were taped by either stretched (elastic group) or non-stretched (placebo group) Kinesio tape at the lower back area for one week. RESULTS: After the application of stretched elastic tape, lower back pain was significantly reduced by 29.4% (p= 0.003) immediately post-taping and by a further 75.4% after wearing the tape for a week. Compared to the placebo group, lower back pain was significantly reduced in the elastic group after one week of wearing the tape (p< 0.001). Compared to placebo, the application of elastic tape significantly reduced the disability score (Roland-Morris Disability Questionnaire) after one week of wearing the tape (p= 0.018). Taping to the back improved walking speed (immediately and after one week) in both the elastic (p< 0.001, p< 0.001) and placebo groups (p< 0.001, p= 0.001); however, the application of either tape had little effect on posture change. CONCLUSION: Elastic tape reduced back pain and improved physical function in pregnant women compared to the placebo tape.


2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Yufeng Chen ◽  
Huilin Yang ◽  
Lianfang Zhang ◽  
Yue Wang ◽  
Jun Zou

Objective. This study aimed to investigate if the presence of Modic changes (MCs) was correlated with lower back pain (LBP) and LBP-related disability in patients who underwent nonsurgical treatment. Methods. In this study, 129 patients who experienced consecutive LBP and underwent lumbar spine magnetic resonance imaging in our institute were divided into three groups according to the presence or type of MCs. The Oswestry Disability Index (ODI) and visual analog scale (VAS) were used to assess the outcomes of the treatment. Results. Based on the achieved results, there was no significant difference between three groups before treatment (P>0.05). Three months after undergoing nonsurgical treatment, the rates of improved ODI and VAS scores were statistically significantly different (P=0.014,  0.023). After an additional 3 months of treatment, in patients with Modic type I changes, the symptoms significantly improved in comparison with those 3 months prior (P=0.037,  0.026), while that improvement did not occur in patients with Modic type II changes (P>0.05). Conclusions. The existence of MCs affects the outcomes of nonsurgical treatment in patients with LBP. However, symptoms can be improved after an additional round of treatment for Modic type I changes, while this is not confirmed for Modic type II changes.


Author(s):  
David Baur ◽  
Richard Bieck ◽  
Johann Berger ◽  
Juliane Neumann ◽  
Jeanette Henkelmann ◽  
...  

Abstract Purpose This single-center study aimed to develop a convolutional neural network to segment multiple consecutive axial magnetic resonance imaging (MRI) slices of the lumbar spinal muscles of patients with lower back pain and automatically classify fatty muscle degeneration. Methods We developed a fully connected deep convolutional neural network (CNN) with a pre-trained U-Net model trained on a dataset of 3,650 axial T2-weighted MRI images from 100 patients with lower back pain. We included all qualities of MRI; the exclusion criteria were fractures, tumors, infection, or spine implants. The training was performed using k-fold cross-validation (k = 10), and performance was evaluated using the dice similarity coefficient (DSC) and cross-sectional area error (CSA error). For clinical correlation, we used a simplified Goutallier classification (SGC) system with three classes. Results The mean DSC was high for overall muscle (0.91) and muscle tissue segmentation (0.83) but showed deficiencies in fatty tissue segmentation (0.51). The CSA error was small for the overall muscle area of 8.42%, and fatty tissue segmentation showed a high mean CSA error of 40.74%. The SGC classification was correctly predicted in 75% of the patients. Conclusion Our fully connected CNN segmented overall muscle and muscle tissue with high precision and recall, as well as good DSC values. The mean predicted SGC values of all available patient axial slices showed promising results. With an overall Error of 25%, further development is needed for clinical implementation. Larger datasets and training of other model architectures are required to segment fatty tissue more accurately.


2020 ◽  
Author(s):  
Isil Yurdaisik ◽  
Süleyman Hilmi Aksoy

Abstract Objective: The objective of this study was to investigate the relationship between spinal curvature and extensor muscle volume in patients who presented to our hospital with lower back pain and were referred to our radiology clinic for imaging investigations.Methods: A total of 150 patients with 87 being female and 63 male who presented to our hospital with the complaint of lower back pain and were referred to our radiology clinic were included in this study. Lumbar angle, lumbosacral angle, wedge angle, sacral horizontal angle, the volume of the right and left PSOAS muscles and the volume of the right and left extensor muscles were calculated and analyzed. Results: A total of 150 patients with lower back pain were included in the study. The mean lumbar angle was found as 44.2±10.6 degrees, and the mean lumbosacral angle as 56.7±10.9 degrees. The mean wedge angle of all patients included in the study was measured as 9.3±3.7 degrees. The mean sacral horizontal angle was found as 33.6±7.1 degrees. The mean right lumbar extensor muscle volume was measured as 2169.6±489.6 mm3, while the mean left lumbar extensor volume was calculated as 2286.5±1452.8 mm3. Conclusion: Our findings indicate a significant positive correlation between the volume of extensor muscles in the lower half of the lumbar spine and sagittal curvature in the same region. Clarifying the relationship between sagittal curvature and lower lumbar muscle size will provide contribution to the management of patients with lower back pain and will be helpful in determining whether these patients would benefit from intensive treatment.


2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Ann-Kathrin Lederer ◽  
Christian Maly ◽  
Tomas Weinert ◽  
Roman Huber

Background. Massage therapies such as cupping are often applied in patients with chronic neck and back pain with the assumption that they can reduce increased tissue stiffness and, therefore, improve pain. The aim of this study was to clarify whether tissue stiffness is related to pain experience in patients with chronic (>3 months) back and neck pain and whether it can be altered by a cupping massage. Methods. The tissue stiffness of the point of subjectively felt maximum pain intensity of 40 patients with neck (n = 20) or lower back pain (n = 20) was measured by a myometer. Exact contralateral side served as an individual control. Side of higher stiffness was then treated with a cupping massage. 5, 10, 15, and 20 minutes as well as 24 hours after treatment, tissue stiffness was measured again. Patients rated their pain on a standardized pain questionnaire (neck pain disability score (NDI) or Oswestry disability index (ODI), respectively) before and 24 hours after treatment. Results. Compared to the contralateral control side, the more painful side did not exhibit an increased stiffness of myofascial tissue before treatment (p=0.827). The tissue stiffness and the side difference between treated and nontreated control sides decreased significantly after cupping (p=0.002 and p=0.001, respectively) but returned to baseline after 24 hours. NDI and ODI scores significantly decreased 24 hours after cupping (NDI: p=0.012, ODI: p=0.002). Conclusion. Tissue stiffness might not be related to pain experience in patients with chronic neck and lower back pain. Trial registration: German Clinical Trial Register (DRKS00011281).


2019 ◽  
Vol 45 ◽  
pp. 33-37
Author(s):  
Daiki Kobayashi ◽  
Takuro Shimbo ◽  
Hana Hayashi ◽  
Osamu Takahashi

2021 ◽  
Author(s):  
Song Guo ◽  
Kai Zhu ◽  
Fu Qiang ◽  
Meiju Yan ◽  
Donghua Hang

Abstract Background Oxidative stress has been considered a critical mediator in the pathogenesis of lumbar disc degeneration, which can lead to the severe lower back pain. Inhibition of the excessive oxidative stress has become a therapeutic target for controlling discogenic lower back pain. Recently, more studies have shown that holmium laser can effectively suppress oxidative stress. This work aims to study the clinical outcomes of percutaneous full-endoscopy spine surgery combined with holmium laser for treating symptomatic lumbar disc degeneration (IDD). Methods We designed and conducted a retrospective study on the patients with lumbar disc herniation who had been treated by percutaneous full-endoscopy spine surgery at Shanghai General Hospital from June 2018 to March 2020. The patients were divided into group A (holmium laser treatment group) and group B (Elliquence radiofrequency group) according to the medical record. Operation time and hospitalization time of both groups were recorded and compared. Additionally, VAS scores and ODI scores were used to evaluate the lower back pain, lower extremity radiation pain and quality of life before and 3 days, 6 months, and 12 months after surgery. Results Forty-five patients were included in group A while the other 55 patients were included in group B. Operation time of group A was significantly shorter than that of group B (40.60±5.59 minutes vs. 50.80±3.19 minutes). VAS scores of lower back pain and lower extremity radiation pain at postoperative 3 days, 6 months, and 12 months were significantly lower than those before surgery in both groups. The postoperative lower back pain VAS scores of group A were significantly lower than those of group B, while the postoperative lower extremity radiation pain VAS scores had no significant difference between both groups. The ODI scores of both groups at postoperative 3 days, 6 months, and 12 months were significantly lower than those before surgery. Conclusions These findings confirmed that application of holmium laser can significantly improve the clinical outcomes in percutaneous full-endoscopy spine surgery.


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