scholarly journals Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

2008 ◽  
Vol 1 (1) ◽  
pp. 5-11 ◽  
Author(s):  
E. Calamelli ◽  
G. Ricci ◽  
V. Dell’Omo ◽  
B. Bendandi ◽  
M. Masi
Keyword(s):  
Food Allergy ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Clinical Severity ◽  
Asthma Prevalence ◽  
Epidemiological Evidence ◽  
Prick Test ◽  
Asthmatic Children ◽  
Children With Asthma

Epidemiological evidence suggests that there is a link between asthma and food allergy. The aim of this study was to estimate the prevalence of food allergy in asthmatic children and to evaluate a possible impact of food allergy on asthma severity. The study enrolled 103 asthmatic children (mean age: 11 years). Skin prick-test, dosage of specific IgE to a standardized panel of inhalant and food allergens and spirometric evaluation was made for each patient. Twenty-four (23%) patients presented food allergy, 75 (77%) were sensitized to at least one food. A lower rate of children with controlled symptoms was found in children with food allergy and a higher rate of persistent asthma was found in children sensitized to at least 4 foods. In conclusion, food allergy/sensitization should always be investigated in asthmatic children for its association with increasing severity (only in food sensitized patients) and reduced control of asthmatic symptoms.

Cardiovascular Fitness in Children With Asthma Correlates With Psychologic Functioning of the Child

PEDIATRICS ◽  
1989 ◽  
Vol 84 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Robert C. Strunk ◽  
David A. Mrazek ◽  
Jolene T. Fukuhara ◽  
Jim Masterson ◽  
Susan K. Ludwick ◽  
...  
Keyword(s):  
Global Assessment ◽  
Child Behavior Checklist ◽  
Asthma Severity ◽  
Forced Expiratory Volume ◽  
Cardiovascular Fitness ◽  
Assessment Scale ◽  
Bicycle Ergometry ◽  
Global Assessment Scale ◽  
Asthmatic Children ◽  
Children With Asthma

Abnormalities in fitness in asthmatic children are assumed to derive from illness severity. We studied 90 children with moderately severe to severe but stable asthma for (1) fitness levels using bicycle ergometry, (2) measures of asthma severity, (3) clinician's impression of child (Child Global Assessment Scale), and (4) mother's rating of child's behavior (Child Behavior Checklist). Fitness values ranged from 15% to 120% of normal values for age, sex, and body surface area: 48% were abnormal (<2 SD below mean) and 5% were borderline (1 to 2 SD below mean). Associations between levels of fitness and medical and psychologic criteria were tested using regression analyses. Of the 11 medical variables used to define the severity of asthma, recent exacerbation of disease, forced expiratory volume in 1 second, and specific airway conductance together accounted for 8.1% of the variability in the workload ratios (ie, R2 = 0.081). The importance of the psychologic factors in determining the variability in the workload ratios was tested after the importance of the medical variables had been considered: Child Global Assessment Scale accounted for a significant amount of variability, improving the R2 to 0.180 (an increase to 0.100, P = .003). These data suggest that, within the spectrum of disease presented by the patients in this study, adjustment to the disease is at least as important as severity of disease in determining fitness.

scholarly journals Evaluation of oral functions of the stomatognathic system according to the levels of asthma severity

2012 ◽  
Vol 24 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Mariana San Jorge de Castro ◽  
Adyléia Aparecida Dalbo Contrera Toro ◽  
Eulália Sakano ◽  
José Dirceu Ribeiro
Keyword(s):  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Healthy Children ◽  
Structural Part ◽  
Assessment Protocol ◽  
Group I ◽  
Study Results ◽  
Children With Asthma ◽  
Asthma Group

PURPOSE: To compare the orofacial functions (chewing, swallowing and speech) in children with asthma and healthy children. METHODS: A cross sectional study including 54 children of both genders with ages between 7 and 10 years was conducted. Twenty-seven of these subjects composed the experimental group, and were subdivided into two severity levels of asthma: Group I - mild intermittent and persistent asthma; Group II - persistent moderate to severe asthma. Twenty-seven healthy children were included in the control group (Group III). Speech-language pathology evaluation used the adapted Orofacial Myofunctional Assessment Protocol. Adaptation consisted in the exclusion of the structural part of the test, since this was not the aim of the study. The structural part was excluded because it was not the aim of this study. RESULTS: It was found alterations in oral functions, with significant differences between the three groups. These alterations showed no correlation with asthma severity, since the highest rate of alterations was found in Group I (mild asthma). CONCLUSION: Regardless of the severity level, children with asthma have altered patterns of chewing, swallowing and speech.

scholarly journals Asthma severity in relation to allergenic risk factors in childhood

2005 ◽  
Vol 133 (Suppl. 2) ◽  
pp. 101-104
Author(s):  
Snezana Zivanovic ◽  
Radmila Mileusnic-Milenovic ◽  
Maja Slavkovic-Jovanovic ◽  
Marija Conic
Keyword(s):  
Statistical Significance ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Atopic Asthma ◽  
Dermatophagoides Farinae ◽  
Asthmatic Patients ◽  
Ige Mediated ◽  
Inhalant Allergens ◽  
Airborne Allergens

The majority of asthmatic patients are atopic - that is to say, they exhibit IgE-mediated sensitivity to common inhalant allergens. Exposure and sensitisation to allergens from the housedust mite has been established as an important risk factor in asthma in most parts of the world. The aim of our study was to assess total IgE and specific IgE on airborne allergens (Dermatophagoides pteronyssinus - DP, Dermatophagoides farinae - DF, mould, and grass pollen) in relation to asthma severity. The study involved 64 children with atopic asthma. Statistical significance was present between groups of intermittent and moderately persistent asthma for IgE and specific IgE on DP and moulds. In mild and moderate asthma, statistically significant differences were present for all parameters except for DF.

scholarly journals ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma

2018 ◽  
Vol 21 (1) ◽  
pp. 33-38 ◽  
Author(s):  
N Jovicic ◽  
T Babic ◽  
S Dragicevic ◽  
B Nestorovic ◽  
A Nikolic
Keyword(s):  
Asthma Severity ◽  
Cross Sectional Study ◽  
Asthma Therapy ◽  
Cross Sectional ◽  
Bronchodilator Response ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
Β2 Adrenergic Receptor ◽  
The University ◽  
Inhaled Salbutamol

Abstract Inhaled β2 adrenergic receptor (β2-AR) agonists are the mainstay of asthma therapy. The β2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children’s Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G (Gln27Glu, rs 1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +46G was found to be associated with a better response to inhaled salbutamol (p <0.05) and with mild form of asthma (p <0.05). Polymorphism ADRB2 +46A>G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C>G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.

scholarly journals MP9: SINO-NASAL 5 QUESTIONNAIRE PREDICTS POOR ASTHMA CONTROL IN CHILDREN WITH PERSISTENT ASTHMA

2016 ◽  
Vol 64 (3) ◽  
pp. 808.1-808
Author(s):  
G Phull ◽  
D Prue ◽  
C Martinez ◽  
K Scheffey ◽  
D Pillai
Keyword(s):  
Asthma Control ◽  
Persistent Asthma ◽  
Upper Airway ◽  
Asthma Severity ◽  
Life Questionnaire ◽  
Night Time ◽  
Time Activity ◽  
Asthmatic Children ◽  
Airway Symptoms ◽  
The Impact

Purpose of StudyUp to 80% of asthmatic children may experience upper airway symptoms, including rhinitis, often perceived as coming from lower airways. Asthma diagnosis, classification and assessment of control are defined by the National Asthma Education Prevention Program (NAEPP) 2007 guidelines, but may understate the impact of the upper airway. We explored associations between Sino-Nasal 5 (SN-5) quality of life questionnaire, validated in radiographic confirmed sinus disease, and NAEPP asthma impairment in children. We hypothesize that children with NAEPP defined uncontrolled asthma will have abnormal SN-5 scores.Methods UsedWe performed a retrospective chart review of children (1–21 yr) referred to a pediatric pulmonary clinic for persistent asthma. Data collected include age, gender, BMI%, NAEPP asthma severity, SN-5, asthma control (TRACK children <5 y, ACT children ≥5 y) and pulmonary function testing (PFT). The primary analysis was to identify associations between SN-5 scores and levels of NAEPP guideline impairment: daytime symptoms, night time awakenings, activity interference and PFTs. Significant SN-5 scoring was defined as ≥3.5 based on prior studies. PFT was performed in children ≥5 y. Statistical analysis with SPSS 22.Summary of Results76 children were evaluated; 38% female, mean age 6.9 y and mean BMI% 69%. Significant SN-5 score (≥3.5 vs. <3.5) was associated with decreased control of daytime symptoms (OR 0.16 [95% CI:0.06–0.44]), night time awakenings (OR 0.09 [0.03–0.29]), activity interference (OR 0.2 [0.06–0.68]) and asthma control (OR 0.32 [0.12–0.85]). Those with SN-5 ≥3.5 had poor asthma control based on TRACK (p<0.002) and ACT (p<0.001). Age, gender, BMI%, asthma severity and PFTs were not associated with SN-5.ConclusionsIn persistent asthmatic children, NAEPP defined daytime, night time, activity related impairment and poor asthma control were associated with a significant SN-5 score; PFTs and NAEPP asthma severity were not. This suggests that upper airways may play a larger role in lower airway associated symptoms, and that SN-5 may be beneficial in assessing asthma symptoms. Recognizing and treating upper airway symptoms, an understated area in asthma guidelines, might improve overall asthma control. A prospective analysis in a larger cohort is recommended to evaluate these findings.

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