scholarly journals Asthma severity in relation to allergenic risk factors in childhood

2005 ◽  
Vol 133 (Suppl. 2) ◽  
pp. 101-104
Author(s):  
Snezana Zivanovic ◽  
Radmila Mileusnic-Milenovic ◽  
Maja Slavkovic-Jovanovic ◽  
Marija Conic
Keyword(s):  
Statistical Significance ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Atopic Asthma ◽  
Dermatophagoides Farinae ◽  
Asthmatic Patients ◽  
Ige Mediated ◽  
Inhalant Allergens ◽  
Airborne Allergens

The majority of asthmatic patients are atopic - that is to say, they exhibit IgE-mediated sensitivity to common inhalant allergens. Exposure and sensitisation to allergens from the housedust mite has been established as an important risk factor in asthma in most parts of the world. The aim of our study was to assess total IgE and specific IgE on airborne allergens (Dermatophagoides pteronyssinus - DP, Dermatophagoides farinae - DF, mould, and grass pollen) in relation to asthma severity. The study involved 64 children with atopic asthma. Statistical significance was present between groups of intermittent and moderately persistent asthma for IgE and specific IgE on DP and moulds. In mild and moderate asthma, statistically significant differences were present for all parameters except for DF.

scholarly journals Food and Aeroallergen Sensitization in IgE -Mediated Asthma in Egypt

2021 ◽  
Vol 15 (1) ◽  
pp. 52-58
Author(s):  
Abdellah H.K. Ali
Keyword(s):  
Specific Ige ◽  
Cross Sectional Study ◽  
House Dust Mites ◽  
Atopic Asthma ◽  
Food Allergens ◽  
Cross Sectional ◽  
Asthmatic Patients ◽  
Egyptian Patients ◽  
Ige Mediated ◽  
Effective Diagnosis

Purpose: Identifying the distribution of allergens is valuable to the effective diagnosis and treatment of allergic disease. So, our aim is to explore the sensitization of food and aeroallergens in Egyptian patients with atopic asthma. Methods: Cross-sectional study recruited 268 Egyptian patients with atopic asthma. Asthmatic patients were assessed by the enzyme allegro sorbent test (EAST) method for specific IgE to a panel of 19 common regional inhaled allergens and 15 food allergens. Results and Discussion: One hundred percent of the patients were sensitive to at least one allergen. Allergy to food allergens only was 2.9%; inhaled allergens only were 26.2% and both were70.9%. Fungi (62%) were the most frequent sensitizing aeroallergen amongst our asthmatic patients, followed by the pollen allergens (42.5%) and house dust mites (HDMs) (26%). Cows’ milk (30.5%) was the most frequent sensitizing food amongst our asthmatic patients, followed by eggs (22.4%) and fish (21.6%). Mono-sensitized patients accounted for 6.7% of all cases, while polysensitized was 93.3%. Moderate and severe asthma showed a significantly higher frequency of polysensitization compared to mild asthma. Conclusion: Fungi and cow's milk are the chief sensitizing allergens in Egyptian patients with atopic asthma. This study represents the first report of sensitization in atopic adult asthma using a large extract panel in Upper Egypt.

scholarly journals Oral Curcumin Supplementation in Patients with Atopic Asthma

2011 ◽  
Vol 2 (2) ◽  
pp. ar.2011.2.0016 ◽  
Author(s):  
Dennis H. Kim ◽  
Joshua F. Phillips ◽  
Richard F. Lockey
Keyword(s):  
Allergic Sensitization ◽  
Persistent Asthma ◽  
Specific Ige ◽  
Atopic Asthma ◽  
In Vivo Studies ◽  
Inhaled Corticosteroid ◽  
End Point ◽  
Cytokine Responses ◽  
Anti Inflammatory

Oral curcumin is recognized to have anti-inflammatory properties and has been used by ancient traditional medicine for centuries to treat a variety of diseases. In vitro studies have confirmed the ability of curcumin to inhibit allergic inflammatory cytokine responses from lymphocytes; however, there are no in vivo studies of curcumin to treat inflammation associated with allergic asthma. This study was designed to determine the effect of oral curcumin supplementation on patients with stable, persistent, atopic asthma. Adult patients with stable, persistent asthma with evidence of allergic sensitization were randomized to receive 1000 mg of curcumin twice daily or placebo. Subjects were followed for 6 months and performed monthly spirometry (pre- and postbronchodilator); Asthma Control Test (ACT) scoring; and measurements for fractional excretion of nitric oxide (NO), serum eosinophil count, leukocyte count, total IgE, specific IgE to Dermatophagoides pteronyssinus ( Der p) and Dermatophagoides farinae ( Der f), use of rescue albuterol, and dose of inhaled corticosteroid. Nine patients were randomized into the treatment arm and six were randomized into the placebo group. No differential response was seen in the treatment and placebo groups regarding the primary end point, postbronchodilator forced expiratory volume in 1 second (FEV1). Similarly, all secondary end point evaluations were not significantly different. Despite in vitro evidence that curcumin has anti-inflammatory properties and can inhibit allergic cytokine responses from lymphocytes in vitro, curcumin, 1000-mg, twice daily supplementation did not significantly affect postbronchodilator FEV1, ACT scores, use of rescue bronchodilator, dose of inhaled corticosteroid, exhaled NO, serum IgE, total white blood cell count specific IgE to Der p or Der f, and blood eosinophils in patients with persistent atopic asthma.

scholarly journals Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

2008 ◽  
Vol 1 (1) ◽  
pp. 5-11 ◽  
Author(s):  
E. Calamelli ◽  
G. Ricci ◽  
V. Dell’Omo ◽  
B. Bendandi ◽  
M. Masi
Keyword(s):  
Food Allergy ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Clinical Severity ◽  
Asthma Prevalence ◽  
Epidemiological Evidence ◽  
Prick Test ◽  
Asthmatic Children ◽  
Children With Asthma

Epidemiological evidence suggests that there is a link between asthma and food allergy. The aim of this study was to estimate the prevalence of food allergy in asthmatic children and to evaluate a possible impact of food allergy on asthma severity. The study enrolled 103 asthmatic children (mean age: 11 years). Skin prick-test, dosage of specific IgE to a standardized panel of inhalant and food allergens and spirometric evaluation was made for each patient. Twenty-four (23%) patients presented food allergy, 75 (77%) were sensitized to at least one food. A lower rate of children with controlled symptoms was found in children with food allergy and a higher rate of persistent asthma was found in children sensitized to at least 4 foods. In conclusion, food allergy/sensitization should always be investigated in asthmatic children for its association with increasing severity (only in food sensitized patients) and reduced control of asthmatic symptoms.

scholarly journals Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Ragnhild Halvorsen ◽  
Åsa Jenner ◽  
Else Marie Hagelin ◽  
Magnus P. Borres
Keyword(s):  
Young Children ◽  
Clinical Information ◽  
Specific Ige ◽  
In Vitro Test ◽  
Blinded Manner ◽  
Specific Ige Antibodies ◽  
Vitro Test ◽  
Ige Mediated ◽  
Inhalant Allergens

Background and Objective. Allergy-like symptoms such as wheezing and eczema are common in young children and an early diagnosis is important to initiate correct management. The objective of this study was to evaluate the diagnostic performance of Phadiatop Infant, an in vitro test for determination of early sensitisation to food and inhalant allergens.Patients and Methods. The study was conducted, retrospectively, using frozen sera from 122 children (median age 2.7 years) admitted to the hospital with suspected allergic symptoms. The doctor's diagnosis atopic/nonatopic was based on routinely used procedures such as clinical evaluation, SPT, total and allergen-specific IgE antibodies. The performance of Phadiatop Infant was evaluated in a blinded manner against this diagnosis.Results. Eighty-four of the 86 children classified as atopic showed a positive Phadiatop Infant test. Thirty-six were classified as nonatopic, 32 of who had a negative test. With a prevalence of atopy of 70% in this population, this gives a sensitivity of 98%, a specificity of 89%, and a positive and negative predictive value of 95% and 94%, respectively.Conclusion. The results from the present study suggest that Phadiatop Infant could be recommended as a complement to the clinical information in the differential diagnosis on IgE-mediated disease in young children with allergy-like symptoms.

Asthma severity identification from pulmonary acoustic signal for computerized decision support system

2020 ◽  
pp. 1-18
Author(s):  
Fizza Ghulam Nabi ◽  
Kenneth Sundaraj ◽  
Chee Kiang Lam
Keyword(s):  
Statistical Significance ◽  
Asthma Severity ◽  
Tidal Breathing ◽  
Computerized Decision Support ◽  
Severity Level ◽  
Asthmatic Patients ◽  
Breath Sounds ◽  
Lower Lung ◽  
Different Characteristics ◽  
Frequency Features

Abstract Objective: Breath sound has information about underlying pathology and condition of subjects. The purpose of this study is to examine asthmatic acuteness levels (Mild, Moderate, Severe) using frequency features extracted from wheeze sounds. Further, analysis has been extended to observe behavior of wheeze sounds in different datasets. Method: Segmented and validated wheeze sounds was collected from 55 asthmatic patients from the trachea and lower lung base (LLB) during tidal breathing maneuvers. Segmented wheeze sounds have been grouped in to nine datasets based on auscultation location, breath phases and a combination of phase and location. Frequency based features F25, F50, F75, F90, F99 and mean frequency (MF) has been calculated from normalized power spectrum. Subsequently, multivariate analysis has been performed for analysis. Result: Generally frequency features observe statistical significance (p < 0.05) for the majority of datasets to differentiate severity level ? = 0.432-0.939, F(12, 196-1534) = 2.731-11.196, p < 0.05, ????2 = 0.061-0.568. It was observed that selected features performed better (higher effect size) for trachea related samples ? = 0.432-0.620, F(12, 196-498) = 6.575-11.196, p < 0.05, ????2 = 0.386-0.568. Conclusion: The results demonstrate that severity levels of asthmatic patients with tidal breathing can be identified through computerized wheeze sound analysis. In general, auscultation location and breath phases produce wheeze sounds with different characteristics. Keywords: Asthma, Breath Sounds, Wheeze Detection, Airway Obstruction, Severity Level Continuous...

scholarly journals Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma

2020 ◽  
Vol 4 (2) ◽  
pp. 61
Author(s):  
Annisa Mulia Anasis ◽  
Anna Rozaliyani ◽  
Heri Wibowo
Keyword(s):  
House Dust ◽  
Immunoglobulin E ◽  
Persistent Asthma ◽  
Specific Ige ◽  
Bronchial Tree ◽  
House Dust Mites ◽  
Dust Mites ◽  
Serum Ige ◽  
Asthmatic Patients ◽  
Asthma Group

Background: Asthma is a chronic inflammation of the bronchial tree that emerges as a response to exogenous factors, such as allergens, irritants, and infections. Some asthmatic patients had been reported having symptoms of asthma due to house-dust mites (HDM) allergen exposure. It is associated with immune responses which were increased in the form of specific Immunoglobulin E (IgE) production against HDM allergens. This case-control study aimed to determine the HDM profiles in persistent asthmatic patients, including density of mites, as well as its relationship with specific IgE anti-HDM serum levels.Materials and Methods: A total of 13 patients with persistent asthma and 12 control patients had their specific anti-HDM IgE levels examined using Immulite 2000 xpi. The house dust samples were taken and analyzed with the Fain method.Results: The results have shown that 69% of patients in the persistent asthma group and 25% of normal patients were positive for IgE anti-HDM. Dermatophagoides pteronyssinus is a predominant species with a total of 120 mites (83.9%) of 143 mites. Correlation analysis indicated a positive relationship between IgE anti-HDM levels within the serums of patients and the density of mites in the dust obtained from bedroom spaces (Spearmen Rho, R=0.35, p=0.04).Conclusion: Positive IgE anti-HDM patients in the persistent asthma group were higher (69%) than those in the clinically normal group (25%). The density of mites were dominated by D. Pteronyssinus. The bedroom-dust mites density revealed a positive correlation with serum IgE anti-HDM levels in persistent asthma patients.Keywords: asthma, density, Dermatophagoides spp.,IgE

Component resolved diagnostics in peanut sensitized children with and without a history of clinical reaction

2020 ◽  
Vol 41 (5) ◽  
pp. 336-340
Author(s):  
Yasmin Hamzavi Abedi ◽  
Cristina P. Sison ◽  
Punita Ponda
Keyword(s):  
Retrospective Chart Review ◽  
Clinical History ◽  
Specific Ige ◽  
Exact Test ◽  
Ara H 1 ◽  
Sige Level ◽  
History Of ◽  
Laboratory Procedures ◽  
Ige Mediated ◽  
The Relationship

Background: Serum Peanut-specific-IgE (PN-sIgE) and peanut-component-resolved-diagnostics (CRD) are often ordered simultaneously in the evaluation for peanut allergy. Results often guide the plans for peanut oral challenge. However, the clinical utility of CRD at different total PN-sIgE levels is unclear. A commonly used predefined CRD Ara h2 cutoff value in the literature predicting probability of peanut challenge outcomes is 0.35kUA/L. Objective: To examine the utility of CRD in patients with and without a history of clinical reactivity to peanut (PN). Methods: This was a retrospective chart review of 196 children with PN-sIgE and CRD testing, of which, 98 patients had a clinical history of an IgE-mediated reaction when exposed to PN and 98 did not. The Fisher's exact test was used to assess the relationship between CRD and PN-sIgE at different cutoff levels, McNemar test and Gwet’s approach (AC1 statistic) were used to examine agreement between CRD and PN-sIgE, and logistic regression was used to assess differences in the findings between patients with and without reaction history. Results: Ara h 1, 2, 3, or 9 (ARAH) levels ≤0.35 kUA/L were significantly associated with PN-sIgE levels <2 kUA/L rather than ≥2 kUA/L (p < 0.0001). When the ARAH threshold was increased to 1 kUA/L and 2 kUA/L, these thresholds were still significantly associated with PN-sIgE levels of <2, <5, and <14 kUA/L. These findings were not significantly different in patients with and without a history of clinical reactivity. Conclusion: ARAH values correlated with PN-sIgE. Regardless of clinical history, ARAH levels are unlikely to be below 0.35, 1, or 2 kUA/L if the PN-sIgE level is >2 kUA/L. Thus, if possible, practitioners should consider PN-sIgE rather than automatically ordering CRD with PN-sIgE every time. Laboratory procedures that allow automatically and reflexively adding CRD when the PN-sIgE level is ≤5 kUA/L can be helpful. However, further studies are needed in subjects with challenge-proven PN allergy.

Immunotheraphy in Allergic Diseases

2018 ◽  
Vol 24 (11) ◽  
pp. 1174-1194
Author(s):  
Albert Roger ◽  
Maria Basagana ◽  
Aina Teniente-Serra ◽  
Nathalie Depreux ◽  
Yanina Jurgens ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
World Population ◽  
Allergen Specific Immunotherapy ◽  
Routes Of Administration ◽  
Disease Modifying Therapy ◽  
History Of ◽  
Ige Mediated ◽  
Special Case

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

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