scholarly journals Evaluation of oral functions of the stomatognathic system according to the levels of asthma severity

2012 ◽  
Vol 24 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Mariana San Jorge de Castro ◽  
Adyléia Aparecida Dalbo Contrera Toro ◽  
Eulália Sakano ◽  
José Dirceu Ribeiro
Keyword(s):  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Healthy Children ◽  
Structural Part ◽  
Assessment Protocol ◽  
Group I ◽  
Study Results ◽  
Children With Asthma ◽  
Asthma Group

PURPOSE: To compare the orofacial functions (chewing, swallowing and speech) in children with asthma and healthy children. METHODS: A cross sectional study including 54 children of both genders with ages between 7 and 10 years was conducted. Twenty-seven of these subjects composed the experimental group, and were subdivided into two severity levels of asthma: Group I - mild intermittent and persistent asthma; Group II - persistent moderate to severe asthma. Twenty-seven healthy children were included in the control group (Group III). Speech-language pathology evaluation used the adapted Orofacial Myofunctional Assessment Protocol. Adaptation consisted in the exclusion of the structural part of the test, since this was not the aim of the study. The structural part was excluded because it was not the aim of this study. RESULTS: It was found alterations in oral functions, with significant differences between the three groups. These alterations showed no correlation with asthma severity, since the highest rate of alterations was found in Group I (mild asthma). CONCLUSION: Regardless of the severity level, children with asthma have altered patterns of chewing, swallowing and speech.

scholarly journals Quality of Life in Children with Asthma versus Healthy Children

2018 ◽  
Vol 6 (8) ◽  
pp. 1413-1418 ◽  
Author(s):  
Samaneh Kouzegaran ◽  
Parisa Samimi ◽  
Hamid Ahanchian ◽  
Maryam Khoshkhui ◽  
Fatemeh Behmanesh
Keyword(s):  
Quality Of Life ◽  
Physical Performance ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
And Performance ◽  
Asthma Group

BACKGROUND: Asthma is the most prevalent chronic disease in the pediatric age group. The disease affects different aspects of the children's lives, such as physical, emotional, social and educational aspects. Thus, more focus has been on the quality of life in these patients rather than the duration of their illness in recent years.AIM: This study examined the different aspects of quality of life in asthmatic children for the first time in this geographic area.METHODS: The study was cross-sectional conducted in 2015-2016. The asthmatic group was 100 patients aged 8 to 12 admitted to the Asthma and Allergy Clinic of Ghaem Hospital (as) in Mashhad with the control group composed of 100 healthy children of the same age and gender. The standard questionnaire pedsQLTM was used for comparing the quality of life of children in the two groups. Statistical analysis was SPSS23 with P-value less than 0.05, which was statistically significant.RESULTS: In each group, 58 patients were boys, and 42 were girls. In a comparison of the quality of life of children, the asthma group with a mean total score of Peds QL 20.99 ± 12.54 compared to the healthy children with a mean total score of Peds QL of 8.8 ± 5.41 had a lower quality of life (P < 0.001). Moreover, regarding various aspects of quality of life asthma group had a lower quality of life in physical performance, emotional performance and performance in school (P < 0.001). Nonetheless, there was no significant difference between the two groups considering social function (P = 0.267). Examining the relationship between Peds QL score of patients with asthma with various variables was indicative of the fact that Peds QL scores were significantly correlated with the gender of the patients, showing better quality of life in the girls (P = 0.001).CONCLUSION: The results indicated that children with asthma have a significantly lower quality of life compared with healthy children of the same age. Also, in examining the different aspects of quality of life, these children had a lower quality of life in physical performance, emotional performance, and performance at school, and were at the level as that of healthy children only in social performance.

scholarly journals Relationship between montelukast and behavioral problems in preschool children with asthma

2022 ◽  
Vol 50 (1) ◽  
pp. 85-91
Author(s):  
Eda Özata ◽  
Zülfikar Akelma ◽  
Sacit Günbey
Keyword(s):  
Preschool Children ◽  
Behavioral Problems ◽  
Inhaled Corticosteroids ◽  
Controlled Study ◽  
Control Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
Healthy Control ◽  
Asthma Group

Background: There is insufficient clarity regarding whether or not drugs used in asthma cause behavioral problems in children.Methods: A total of 155 individuals, categorized into an asthma group (n = 95) and a control group (n = 60), were enrolled in the current prospective controlled study. The asthma group consisted of patients receiving treatment (inhaled corticosteroids [ICS] or montelukast) for at least 1 month. Check Behavior Checklist (CBCL) for ages 1.5–5 scores for the asthma and controls were compared. The asthma group was divided into two subgroups based on prophylactic therapy received, ICS and montelukast, and these groups’ CBCL scores were also compared. Results: The asthma group consisted of 95 children (ICS subgroup 45, montelukast subgroup 50) and the healthy control group of 60 cases. The mean total CBCL score was higher in the asthma group than in the control group (42 vs 32, respectively, P = 0.001). Internalization and externalization scores were also higher in the asthma group compared to the control group (P = 0.004 and P = 0.005, respectively). No significant difference was determined in terms of CBCL scores between the ICS and montelukast groups (P = 0.3). Montelukast was discontinued in one asthmatic child due to hallucination.Conclusion: This study determined a higher rate of behavioral problems in preschool children with asthma compared to healthy children. In contrast to other studies in the literature, we determined no difference in terms of total CBCL, and internalization and externalization scores of children with asthma who received ICS and montelukast. Nevertheless, it should be kept in mind that montelukast may cause serious neuropsychiatric events such as hallucination.

scholarly journals The influence of leptin on Th1/Th2 balance in obese children with asthma

2013 ◽  
Vol 39 (5) ◽  
pp. 562-568 ◽  
Author(s):  
Doaa Mohammed Youssef ◽  
Rabab Mohamed Elbehidy ◽  
Dina Mahamoud Shokry ◽  
Eman Mohamed Elbehidy
Keyword(s):  
Asthma Symptom ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Obese Children ◽  
Serum Leptin ◽  
Severe Persistent Asthma ◽  
Children With Asthma ◽  
Ifn Γ ◽  
Th1 Polarization ◽  
Asthma Group

OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association between serum leptin levels and clinical outcomes. METHODS: We evaluated 50 atopic children with physician-diagnosed moderate-to-severe persistent asthma and 20 controls. The children with asthma were divided into two groups, by body mass index percentile: obese (n = 25) and non-obese (n = 25). From all subjects, we collected peripheral blood samples in order to determine the levels of leptin, IFN-γ, and IL-4. Asthma severity was assessed by an asthma symptom score, and the results were correlated with the parameters studied. RESULTS: Serum leptin levels were significantly higher in the obese asthma group than in the non-obese asthma group, as well as being significantly higher in the children with asthma than in the controls, whereas IFN-γ levels were significantly higher and IL-4 levels were significantly lower in the obese asthma group than in the non-obese asthma group. In addition, the obese asthma group showed higher asthma symptom scores and significantly lower FEV1 (% of predicted) than did the non-obese asthma group. There was a significant positive correlation between leptin and IFN-γ levels only in the obese asthma group. CONCLUSIONS: Although leptin is involved in the pathogenesis of asthma in obese and non-obese children, its effect is more pronounced in the former. In the presence of high leptin levels, only obese children with asthma exhibited Th1 polarization, with higher IFN-γ levels and greater asthma severity.

scholarly journals The effects of maternal anxiety and attitudes on the adherence to inhaled corticosteroids in children with asthma

2021 ◽  
Vol 49 (3) ◽  
pp. 138-145
Author(s):  
Ozlem Sancakli ◽  
Asli Akin Aslan
Keyword(s):  
Treatment Adherence ◽  
Patient Group ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Maternal Anxiety ◽  
Control Group ◽  
Healthy Children ◽  
Asthma Control Test ◽  
Parent Attitude ◽  
Children With Asthma

Objective: Long-term inhaled corticosteroid (ICS) use in children with asthma causes serious concerns in parents, leading to treatment non-adherence. This study aimed to investigate the effect of maternal anxiety and attitudes on adherence to ICS therapy in children with asthma. Method: The patient group included the children with mild to moderate persistent asthma, aged 6–11 years. Healthy children in a similar age range were included as a control group. The patient group was divided into two categories (treatment adherent and non-adherent) accord-ing to the regularity of ICS use. All patients were assessed with Childhood-Asthma Control Test (C-ACT), and their mothers were assessed using Parent Attitude Research Instrument (PARI) and Beck’s Anxiety Inventory (BAI).Results: A total of 156 children (age: 7.4 ± 1.4 years, F/M: 71/85) with persistent asthma and 60 healthy children (age: 7.5 ± 1.3 years, F/M:25/35) were included in the study. The rate of adher-ence in children with asthma was 52.6%. Mothers of non-adherent patients had significantly higher BAI scores than those of the adherent patients and controls (p < 0.001 and p < 0.001, respectively). The number of mothers who indicated that they did not have enough informa-tion about asthma and treatment was also higher in the non-adherent group. PARI subtest scores were not different between the adherent and non-adherent groups.Conclusions: In our study, it was found that mothers’ anxiety levels and their knowledge about asthma and medications were associated with treatment adherence in children with asthma. Psychological and educational support to the families of children with asthma would improve their treatment adherence and efficacy.

NATRIURETIC PEPTIDES LEVEL AND THE STATUS OF THE RENIN – ANGIOTENSIN-ALDOSTERONE SYSTEM IN CHRONIC KIDNEY DISEASE IN PATIENTS WITH CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM

2018 ◽  
Vol 22 (5) ◽  
pp. 45-50
Author(s):  
A. M. Mambetova ◽  
A. M. Inarokova ◽  
N. N. Shabalova ◽  
D. V. Bizheva ◽  
A. T. Mahiyeva
Keyword(s):  
Congenital Malformations ◽  
Control Group ◽  
Healthy Children ◽  
Urinary System ◽  
Renin Angiotensin Aldosterone System ◽  
Natriuretic Hormone ◽  
Renin Angiotensin ◽  
Group I ◽  
The Status ◽  
Sick Children

THE AIM. To determine the concentration of natriuretic peptide in the blood serum in children with congenital malformations of the urinary system (CM US) and to compare with the activity of renin-angiotensin-aldosterone system (RAAS).MATERIALS AND METHODS.119 patients with CM US aged 3 to 18 years were examined. A control group of 10 clinically healthy children. 3 groups were assigned: group I – 55 children with  congenital vesicoureteral reflux, and group II – 34 children with  congenital hydronephrosis and ureterohydronephrosis, III group – 30 children with other forms of dysembryogenesis of the US. Following indicators were identified by ELISA in the blood: renin, aldosterone,  N – terminal propeptide natriuretic hormone (NT-рroВNР). RESULTS.NT-рroВNР, renin and aldosterone hyperproduction were diagnosed in 59,6%, 69,7%, 54.6 % of sick children relatively. Concentrations were higher in all variants of  malformations in comparison with the control group. Significant  differences were revealed in obstructive species, where arterial  hypertension (AH) was diagnosed more often. Patients with AH  recorded significantly higher concentrations of NT-proВNР and renin.CONCLUSION.The key point in pathological processes developmentand progression in the cardiovascular system and kidneys is the  activation of RAAS. The system of natriuretic factors is important in maintaining the compensated state of patients due to the blockade of RAAS.

Expression Levels of MicroRNA-125b in Serum Exosomes of Patients with Asthma of Different Severity and its Diagnostic Significance

2019 ◽  
Vol 20 (10) ◽  
pp. 781-784 ◽  
Author(s):  
Meizhen Zhao ◽  
Li Juanjuan ◽  
Fan Weijia ◽  
Xie Jing ◽  
Huang Qiuhua ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Roc Curve ◽  
Quantitative Polymerase Chain Reaction ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Spearman Correlation ◽  
Diagnostic Efficacy ◽  
Expression Levels ◽  
Serum Exosomes

Background: This study aimed to investigate the expression levels of microRNA (miRNA)-125b in serum exosomes and its diagnostic efficacy for asthma severity. Methods: The study included 80 patients with untreated asthma and 80 healthy volunteers. The patients were divided into 4 groups according to disease severity: 20 with the intermittent state, 20 with the mildly persistent state, 20 with the moderately persistent state, and 20 with the severely persistent state. The expression levels of miRNA-125b in serum exosomes of each group were detected using a quantitative polymerase chain reaction and compared. The Spearman correlation analysis was used to study the correlation between the expression levels of miRNA-125b in serum exosomes and asthma severity. The diagnostic efficacy of the expression levels of miRNA-125b in exosomes for asthma severity was evaluated using the Receiver Operating Characteristic (ROC) curve. Results: The expression levels of miRNA-125b in serum exosomes of patients with intermittent, mildly persistent, moderately persistent, and severely persistent asthma were all higher than those in the healthy control group, with statistically significant differences. The expression levels of miRNA-125b were also statistically significantly different among patients in each group. The Spearman correlation analysis showed a positive correlation of the relative expression of miRNA-125b in serum exosomes with asthma severity. The area under the ROC curve of the diagnostic efficacy of miRNA-125b in serum exosomes for patients with intermittent, mildly, moderately, and severely persistent asthma was 0.7770, 0.8573, 0.9111, and 0.9995, respectively. Conclusion: The expression levels of miRNA-125b in serum exosomes had a high diagnostic efficacy and might serve as a noninvasive diagnostic marker for asthma severity.

scholarly journals Behavioural Problems and Parental Over-protectiveness in Children with Asthma

2017 ◽  
Vol 36 (3) ◽  
pp. 232-237
Author(s):  
Neena Sanjiv Sawant ◽  
Juhi Bhargava ◽  
Chandrahas T. Deshmukh
Keyword(s):  
Demographic Variables ◽  
Behavioural Problems ◽  
Control Group ◽  
Behaviour Problem ◽  
Early Referral ◽  
Parental Awareness ◽  
Children With Asthma ◽  
Minor Ailments ◽  
And Control ◽  
Asthma Group

Introduction: Asthma in children often leads to behavioural problems due to the chronic nature of the disease. Parents also tend to be overprotective and many may not even consult a doctor for the same. The objectives were to study the various behavioural problems seen in children having asthma as compared to those with minor ailments, parental awareness about the same and their parenting styles.Material and Methods: 75 parents of children of bronchial asthma and 75 parents of children having short term minor ailments formed the asthma and control groups respectively. The Behaviour Problem Index was used to assess the behavioural problems in children as documented by parents and parental overprotectivenesswas assessed using the Vulnerable Child/ Overprotecting Parent Scale.Results:The demographic variables were comparable in both the groups. Behavioural problems on all domains and parental over protectiveness in the asthma group were found to be statistically significant as compared to control group. However there was no significant correlation between the parental over-protectivenessand the behavioural problems in both the groups.Conclusions: Early referral to the psychiatrist with parental counselling will result in better outcomes for the child.J Nepal Paediatr Soc 2016;36(3):232-237

scholarly journals Indicators phenotype lymphocytes and basophils in children with asthma

2016 ◽  
pp. 20-24
Author(s):  
E. Asiryn ◽  
P. Novikov
Keyword(s):  
Reference Values ◽  
Atopic Asthma ◽  
Control Group ◽  
Group Level ◽  
Absolute Level ◽  
Relative Level ◽  
Lymphocyte Phenotype ◽  
Study Results ◽  
Children With Asthma ◽  
The Absolute

The aim of our research to examine the phenotype of lymphocytes and basophils in children with atopic asthma. Materials and methods. A total of 150 children aged 5 to 18 years: 130 patients with asthma, 20 children in the control group. Determines the level of the following indicators of lymphocytes and basophils: СD3+, CD4+, СD4+CD25+, CD19+CD23+, CD203с+, СD203с+CD63+, CD203с+IgE. Results. In the study of lymphocyte phenotype determined that the level of CD4+, СD4+CD25+, CD19+ lymphocytes had no statistically significant differences from the control group of children (p>0,05). The relative level of CD3+ lymphocytes was significantly different from the control group level (p<0,05), but was within the reference values. The level of CD203с+CD63+ basophils, CD203с+IgE was significantly higher in children with asthma than children in the control group (p<0,01), while the absolute level CD203c+ basophils had no significant differences. Conclusion. The findings of the study results suggest that children with asthma the level of activated basophils statistically higher, indicating their participation in the development of the disease.

scholarly journals Neuron-specific blood enolase in children with Helicobacter pylori-associated chronic gastroduodenitis

2019 ◽  
Vol 16 (2) ◽  
pp. 151-155
Author(s):  
S. Kh. Dombayan ◽  
I. V. Panova ◽  
G. M. Letifov
Keyword(s):  
Mucous Membrane ◽  
Inflammatory Process ◽  
Neuron Specific Enolase ◽  
Control Group ◽  
Healthy Children ◽  
Serological Tests ◽  
Group I ◽  
Group Ii ◽  
Severity Of The Disease ◽  
Gastroduodenal Zone

The aim of the study was to assess the level of blood neuron specific enolase (NSE) in children with chronic gastroduodenitis (CGD) depending on Hеlicobacter pylori (HP), the severity of the inflammatory process, sex. The study involved 73 children with CGD. Group I– children with CGD associated with HP (HP CGD+); group II – with CGD not associated with HP (CGD, HP–). The control group (GK) – 28 healthy children. In the diagnosis of the disease, the endoscopic and morphological methods were used; the urease, microscopy, molecular biological and serological tests were performed to verify HP. The elevated levels of NSE were revealed in children groups I and II compared with GK (p < 0.01, p < 0.01). High levels of NSE in serum were observed in boys with CGD HP+ compared with girls with CGD HP+ (p < 0.01). Similar changes related to the gender were identified in group II (p < 0.01). In group I the highest values of NSE were identified with erosive gastroduodenitis (p < 0.01). In group II the opposite direction of enzyme changes was revealed and depended on the severity of the disease. Тhe increase of NSE in the blood of children with CGD HP+ and HP-indicates the presence of enzyme in the mechanisms of the inflammatory process in the mucous membrane gastroduodenal area outside the continuum of HP-infection. A multidirectional character of NSE changes depending on the characteristics of lesions mucous membrane gastroduodenal zone in groups I and II does not exclude the NSE involvement into the mechanisms of formation of the severity of the disease. Higher levels of NSE in boys as in CGD, HP+ and HP – do not exclude the relations of NSE and sex hormones.

scholarly journals Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

2008 ◽  
Vol 1 (1) ◽  
pp. 5-11 ◽  
Author(s):  
E. Calamelli ◽  
G. Ricci ◽  
V. Dell’Omo ◽  
B. Bendandi ◽  
M. Masi
Keyword(s):  
Food Allergy ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Clinical Severity ◽  
Asthma Prevalence ◽  
Epidemiological Evidence ◽  
Prick Test ◽  
Asthmatic Children ◽  
Children With Asthma

Epidemiological evidence suggests that there is a link between asthma and food allergy. The aim of this study was to estimate the prevalence of food allergy in asthmatic children and to evaluate a possible impact of food allergy on asthma severity. The study enrolled 103 asthmatic children (mean age: 11 years). Skin prick-test, dosage of specific IgE to a standardized panel of inhalant and food allergens and spirometric evaluation was made for each patient. Twenty-four (23%) patients presented food allergy, 75 (77%) were sensitized to at least one food. A lower rate of children with controlled symptoms was found in children with food allergy and a higher rate of persistent asthma was found in children sensitized to at least 4 foods. In conclusion, food allergy/sensitization should always be investigated in asthmatic children for its association with increasing severity (only in food sensitized patients) and reduced control of asthmatic symptoms.

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