scholarly journals MP9: SINO-NASAL 5 QUESTIONNAIRE PREDICTS POOR ASTHMA CONTROL IN CHILDREN WITH PERSISTENT ASTHMA

2016 ◽  
Vol 64 (3) ◽  
pp. 808.1-808
Author(s):  
G Phull ◽  
D Prue ◽  
C Martinez ◽  
K Scheffey ◽  
D Pillai
Keyword(s):  
Asthma Control ◽  
Persistent Asthma ◽  
Upper Airway ◽  
Asthma Severity ◽  
Life Questionnaire ◽  
Night Time ◽  
Time Activity ◽  
Asthmatic Children ◽  
Airway Symptoms ◽  
The Impact

Purpose of StudyUp to 80% of asthmatic children may experience upper airway symptoms, including rhinitis, often perceived as coming from lower airways. Asthma diagnosis, classification and assessment of control are defined by the National Asthma Education Prevention Program (NAEPP) 2007 guidelines, but may understate the impact of the upper airway. We explored associations between Sino-Nasal 5 (SN-5) quality of life questionnaire, validated in radiographic confirmed sinus disease, and NAEPP asthma impairment in children. We hypothesize that children with NAEPP defined uncontrolled asthma will have abnormal SN-5 scores.Methods UsedWe performed a retrospective chart review of children (1–21 yr) referred to a pediatric pulmonary clinic for persistent asthma. Data collected include age, gender, BMI%, NAEPP asthma severity, SN-5, asthma control (TRACK children <5 y, ACT children ≥5 y) and pulmonary function testing (PFT). The primary analysis was to identify associations between SN-5 scores and levels of NAEPP guideline impairment: daytime symptoms, night time awakenings, activity interference and PFTs. Significant SN-5 scoring was defined as ≥3.5 based on prior studies. PFT was performed in children ≥5 y. Statistical analysis with SPSS 22.Summary of Results76 children were evaluated; 38% female, mean age 6.9 y and mean BMI% 69%. Significant SN-5 score (≥3.5 vs. <3.5) was associated with decreased control of daytime symptoms (OR 0.16 [95% CI:0.06–0.44]), night time awakenings (OR 0.09 [0.03–0.29]), activity interference (OR 0.2 [0.06–0.68]) and asthma control (OR 0.32 [0.12–0.85]). Those with SN-5 ≥3.5 had poor asthma control based on TRACK (p<0.002) and ACT (p<0.001). Age, gender, BMI%, asthma severity and PFTs were not associated with SN-5.ConclusionsIn persistent asthmatic children, NAEPP defined daytime, night time, activity related impairment and poor asthma control were associated with a significant SN-5 score; PFTs and NAEPP asthma severity were not. This suggests that upper airways may play a larger role in lower airway associated symptoms, and that SN-5 may be beneficial in assessing asthma symptoms. Recognizing and treating upper airway symptoms, an understated area in asthma guidelines, might improve overall asthma control. A prospective analysis in a larger cohort is recommended to evaluate these findings.

scholarly journals Relation of Asthma Control with Quality of Life among a Sample of Egyptian Asthmatic School Children

2019 ◽  
Vol 7 (17) ◽  
pp. 2780-2785
Author(s):  
Hala G. Elnady ◽  
Lobna S. Sherif ◽  
Rania N. Sabry ◽  
Dina Abu Zeid ◽  
Hanan Atta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Asthma Severity ◽  
Physical Symptoms ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Asthmatic Children ◽  
Asthmatic Patients ◽  
Egyptian Children

BACKGROUND: Asthma is considered a chronic health illness that not only resulted in physical symptoms but also emotional effects. It is; therefore, so important to assess the quality of life of asthmatic patients besides their level of disease control. AIM: To determine the correlation of asthma control with the health-related quality of life (HRQOL) of asthmatic children in Egypt. METHODS: One hundred and twenty-eight asthmatic Egyptian children were enrolled in the study. They were subjected to asthma severity grading, asthma control questionnaire (ACQ) and pediatric asthma quality of life questionnaire (PAQLQ). Studied cases were taken from 6 primary and preparatory schools, Giza governorate. RESULTS: The mean child control score was significantly higher in not well-controlled asthmatics compared to well-controlled asthmatics (p < 0.005). The not well controlled asthmatic children showed significantly lower activity limitation score, symptoms score, and overall asthmatic score compared to controlled asthmatic children (p < 0.05). The severity of asthma shows significant positive correlation with symptoms score, emotional function score and overall asthmatic score (p < 0.05). CONCLUSION: The quality of life for the asthmatic children is strongly correlated with the level of asthma control and severity.

MP15: PEDIATRIC SLEEP QUESTIONNAIRE DETECTS SLEEP DISORDERED BREATHING IN ASTHMATICS WITH POOR NIGHTTIME CONTROL

2016 ◽  
Vol 64 (3) ◽  
pp. 811.1-811
Author(s):  
R Megalaa ◽  
G Phull ◽  
D Prue ◽  
K Scheffey ◽  
D Pillai
Keyword(s):  
Asthma Control ◽  
Sleep Disordered Breathing ◽  
Retrospective Chart Review ◽  
Asthma Severity ◽  
Night Time ◽  
Sleep Questionnaire ◽  
Asthmatic Children ◽  
Pediatric Sleep Questionnaire ◽  
Disordered Breathing ◽  
Pediatric Sleep

Purpose of StudyUp to 35% of asthmatic children have degrees of sleep disordered breathing (SDB) which may be perceived as uncontrolled asthma. Asthma diagnosis, classification and assessment of control are defined by the National Asthma Education Prevention Program (NAEPP) 2007 guidelines and include nighttime awakenings as one asthma impairment category. Unclear whether this stems from asthma or SDB. The Pediatric Sleep Questionnaire (PSQ) is validated to identify SDB in children; however associations with specific levels of NAEPP guideline's asthma related impairment have not been evaluated. We hypothesize that asthmatic children with impairment only in NAEPP nighttime awakenings, but not other categories, will have a positive PSQ score (>0.33), suggesting screening for SDB.Methods UsedWe performed a retrospective chart review of children (age 1–21 yrs) referred to a pediatric pulmonary clinic. Data collected included age, gender, BMI%, spirometry, PSQ, asthma control (TRACK <5 yrs, ACT ≥5 yrs), and NAEPP asthma severity, control and impairment. Significant PSQ scoring is >0.33 based on previous validation. Spirometry was performed in children ≥5 yrs. Statistical analysis performed with SPSS 22.Summary of Results76 inner-city children were included in this study; 38% female, mean age 6.9 y, and mean BMI% 69%. Significant PSQ scoring (>0.33 vs ≤0.33) was associated with night time awakenings (OR 11.4 [95% CI:3.7–35.2]) and decreased asthma control seen in TRACK (p<0.003) and ACT questionnaires (p<0.001). Overweight/obese status (BMI% ≥85), spirometry, asthma severity, activity interference and daytime symptoms were not associated with a significant PSQ score.ConclusionsIn asthmatic children, impairment in night time awakenings as defined by NAEPP guidelines was associated with a significant PSQ score, and poor asthma control, based on abnormal TRACK and ACT scores, however other NAEPP categories of impairment; daytime symptoms, activity interference, asthma severity and control, were not. This suggests that screening SDB with the PSQ in children with night time awakenings based on NAEPP criteria may detect underlying SDB. This may lead to further investigations, treatment and subsequent improvement in asthma symptoms. A prospective analysis in a larger cohort is recommended to validate these findings.

scholarly journals Quality of life and asthma control in pregnant women with asthma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nasrin Fazel ◽  
Michael Kundi ◽  
Erika Jensen-Jarolim ◽  
Isabella Maria Pali-Schöll ◽  
Asghar Kazemzadeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Respiratory Illness ◽  
Asthma Severity ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Adverse Pregnancy

Abstract Background Asthma is the most commonly occurring respiratory illness during pregnancy. Associations with complications of pregnancy and adverse perinatal outcome have been established. However, little is known about quality of life (QoL) in pregnant women with asthma and how it relates to asthma control particularly for Iran. Objective To determine the relationship between asthma related QoL and asthma control and severity. Methods We conducted a prospective study in pregnant women with asthma. We used the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire (AQLQ) and the guidelines of the Global Initiative for Asthma for assessment of asthma severity. Results Among 1603 pregnant women, 34 were diagnosed with asthma. Of these 13 had intermittent, 10 mild, 8 moderate and 3 severe persistent asthma. There was a significant decrease of QoL with poorer asthma control (p = 0.014). This decline could be due to limitations of activity in those with poorer asthma control, which is underlined by the significant decline of QoL with increasing asthma severity (p = 0.024). Conclusion Although the majority of pregnant women with asthma had a favorable score in AQLQ, reduced QoL was related to increased asthma severity and poor asthma control. This underlines the importance of controlling asthma during pregnancy not only for the prevention of adverse pregnancy outcomes but also for the preservation of QoL.

scholarly journals The upper-airway microbiota and loss of asthma control among asthmatic children

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanjiao Zhou ◽  
Daniel Jackson ◽  
Leonard B. Bacharier ◽  
David Mauger ◽  
Homer Boushey ◽  
...  
Keyword(s):  
Asthma Control ◽  
Asthma Exacerbation ◽  
Upper Airway ◽  
Severe Exacerbation ◽  
Asthmatic Children ◽  
Time Points ◽  
Asthma Exacerbations ◽  
Severe Asthma Exacerbation ◽  
Airway Microbiome ◽  
One Year

AbstractThe airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota’s dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium’s relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).

scholarly journals Understanding asthma-specific quality of life: moving beyond asthma symptoms and severity

2015 ◽  
Vol 46 (3) ◽  
pp. 680-687 ◽  
Author(s):  
Brian D. Stucky ◽  
Cathy D. Sherbourne ◽  
Maria Orlando Edelen ◽  
Nicole K. Eberhart
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Negative Impact ◽  
Control Measure ◽  
Asthma Severity ◽  
Asthma Symptoms ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
The Impact

This study identifies the unique contributions of asthma severity, symptoms, control and generic measures of quality of life (QoL) to asthma-specific QoL, as measured by the 12-item RAND Negative Impact of Asthma on Quality of Life scale (RAND-IAQL-12).Using a sample of 2032 adults with asthma, we conducted multiple regression analyses that sequentially examined hypothesised predictors of asthma-specific QoL. The change in variance accounted for and total unique variance accounted for is calculated as hypothesised predictors are added in each step.Our results indicate that asthma severity and asthma symptoms are strong predictors of asthma-specific QoL only when not controlling for aspects of asthma control. In regression models that include other aspects of asthma control, the contributions of both asthma symptoms and severity were substantially reduced, with asthma control and aspects of QoL related to social roles and activities emerging as the strongest predictors of asthma-specific QoL.These findings suggest that researchers measuring the impact of asthma on QoL should also consider the importance of asthma control as measured by the RAND Asthma Control Measure (RAND-ACM) and generic QoL scales that measure aspects of daily life that are uniquely affected by asthma.

scholarly journals Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

2008 ◽  
Vol 1 (1) ◽  
pp. 5-11 ◽  
Author(s):  
E. Calamelli ◽  
G. Ricci ◽  
V. Dell’Omo ◽  
B. Bendandi ◽  
M. Masi
Keyword(s):  
Food Allergy ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Clinical Severity ◽  
Asthma Prevalence ◽  
Epidemiological Evidence ◽  
Prick Test ◽  
Asthmatic Children ◽  
Children With Asthma

Epidemiological evidence suggests that there is a link between asthma and food allergy. The aim of this study was to estimate the prevalence of food allergy in asthmatic children and to evaluate a possible impact of food allergy on asthma severity. The study enrolled 103 asthmatic children (mean age: 11 years). Skin prick-test, dosage of specific IgE to a standardized panel of inhalant and food allergens and spirometric evaluation was made for each patient. Twenty-four (23%) patients presented food allergy, 75 (77%) were sensitized to at least one food. A lower rate of children with controlled symptoms was found in children with food allergy and a higher rate of persistent asthma was found in children sensitized to at least 4 foods. In conclusion, food allergy/sensitization should always be investigated in asthmatic children for its association with increasing severity (only in food sensitized patients) and reduced control of asthmatic symptoms.

scholarly journals Assessment of Asthma Control and Severity among Children According to Global Initiative for Asthma Guidelines in Sulaimani City-Iraq

2016 ◽  
Vol 12 (3) ◽  
pp. 160
Author(s):  
Adnan M. H. Hamawandi ◽  
Kosar M Ali ◽  
Ali Z. Naji
Keyword(s):  
Asthma Control ◽  
Objective Assessment ◽  
Asthma Management ◽  
Persistent Asthma ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Global Initiative For Asthma ◽  
Severe Persistent Asthma ◽  
Global Initiative ◽  
Gina Guidelines

Background: Asthma is a common and potentially serious chronic disease that imposes a substantial burden on patients, their families and the community. Objective: Assessment of the level of asthma control and severity in asthmatic children in Sulaimani city according to the global initiative for asthma (GINA) guidelines. Methods: A cross-sectional study of 82 patients who are known cases of asthma, aged 5 – 15 years , from 1st of March 2014 to 1st of August 2014. Results: Out of 82 patients in our study, 20.8%were classified as having intermittent asthma all of them have well controlled asthma, 42.7% of those classified as having mild persistent asthma 65.7% of them have well controlled asthma, 26.8% of those classified as having moderate persistent asthma 54.5% of them have partly controlled asthma, and 9.8%of those classified as having severe persistent asthma the majority of them 87.5% have uncontrolled asthma and none of them reached to the controlled asthma level according to GINA guidelines. Regarding the peak expiratory flow (PFT) we notice that 58.8% of asthmatic children who were classified as having intermittent severity, their PEF measurements ranged between 160- 250 l/min while those with severe persistent asthma 75% of them have readings between 50-150 l/min. Conclusion: Current levels of asthma control in the Sulaimani city fall far short of the goals specified in the GINA guidelines for asthma management. Also there is a strong correlation between PEF measurements and the level of asthma severity,

Controlled Trial of a Home and Ambulatory Program for Asthmatic Children

PEDIATRICS ◽  
1991 ◽  
Vol 87 (1) ◽  
pp. 54-61
Author(s):  
Daniel M. Hughes ◽  
Marjorie McLeod ◽  
Barry Garner ◽  
Richard B. Goldbloom
Keyword(s):  
Controlled Trial ◽  
Asthma Management ◽  
Asthma Severity ◽  
Asthmatic Children ◽  
Control Subjects ◽  
Medical Visits ◽  
Airway Function ◽  
Regular Care ◽  
One Year ◽  
The Impact

Care of asthmatic children is often episodic and more therapeutic than preventive. A 2-year randomized, controlled trial involving 95 children measured the impact of a comprehensive home and ambulatory program for pediatric asthma management using objective outcome measures. Interventions for the study group during the first year included 3-month clinic visits, education, and home visits by a specially trained research nurse. Control subjects continued to receive regular care from a family physician or pediatrician. Eighty-nine subjects (93%) completed the study. Study subjects had less school absenteeism than control subjects (10.7 vs. 16.0 days, P = .04) and showed significantly better small airway function after 1 year. Asthma severity improved in 13 study subjects and worsened in 5. The reverse was true for control subjects. Study subjects exhibited better metered aerosol technique than control subjects (P = .0005). Fewer days were spent in hospital by the study subjects admitted compared with control subjects (3.67 vs 11.2 days, P = .02). After 1 year, more study than control families (72.1% vs 33.1%, P = .006) reported that their asthmatic child took responsibility for the asthma management. The intervention failed to reduce exposure to secondhand smoke or to household pets. There were no significant differences in medical visits, theophylline levels, or records of asthma symptoms. One year after discontinuing the intervention, a marked "washout" effect was observed. Comprehensive ambulatory programs of childhood asthma management can improve objective measures of illness severity but must be sustained.

scholarly journals Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Nahla Mohamed Okasha ◽  
Amr Ali Sarhan ◽  
Engy Osman Ahmed
Keyword(s):  
Asthma Control ◽  
House Dust ◽  
Asthma Severity ◽  
House Dust Mites ◽  
Dust Mites ◽  
Asthma Phenotype ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Control Asthma ◽  
Gina Guidelines

Abstract Background House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines. Results The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017. Conclusions HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms. Trial registration ClinicalTrial.gov, NCT04958616.

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