scholarly journals Can Wine and Moderate Alcohol Intake Work as Functional Food Nutraceuticals? A Tribute to Dr. Serge C. Renaud

2014 ◽  
Vol 7 (1) ◽  
pp. 44-48
Author(s):  
Ram B. Singh ◽  
Fabien D. Meester ◽  
Agnieszka Wilkzynska ◽  
D. W. Wilson ◽  
Domnique Lanzmann ◽  
...  
Keyword(s):  
Functional Food ◽  
Alcohol Intake ◽  
Moderate Alcohol Intake

scholarly journals Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras

2020 ◽  
Vol 318 (2) ◽  
pp. G265-G276
Author(s):  
Kinji Asahina ◽  
Steven Balog ◽  
Edward Hwang ◽  
Eugene Moon ◽  
Emily Wan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Alcohol Drinking ◽  
Calcium Binding ◽  
Alcohol Intake ◽  
Western Diet ◽  
Mutant Mice ◽  
Ductal Adenocarcinoma ◽  
Moderate Alcohol Intake

Kras mutations are associated with pancreatic ductal adenocarcinoma (PDAC). Although tobacco smoking, pancreatitis, and obesity are known environmental risk factors for PDAC, the contribution of moderate alcohol intake to PDAC remains elusive. In the present study, we tested whether a combination of risk factors or moderate alcohol intake induces PDAC development in mice. Control Pdx1Cre and Pdx1Cre;LSL- KrasG12D mutant mice were fed a Western alcohol diet containing high levels of cholesterol and saturated fat, 3.5% alcohol, and lipopolysaccharide for 5 mo. In addition, mice were treated with cerulein, for induction of pancreatitis, and nicotine every month. Treatment with all of these risk factors promoted development of advanced pancreatic neoplasia and PDAC in the Pdx1Cre;LSL- KrasG12D mice but not in the control Pdx1Cre mice. Moderate alcohol intake or Western diet feeding also significantly promoted advanced neoplasia and PDAC development in Pdx1Cre;LSL- KrasG12D mice compared with mice fed a regular chow. Alcohol, but not Western diet, increased tumor development in the liver in the Pdx1Cre;LSL- KrasG12D mice, but its origin remained elusive due to leakiness of Pdx1Cre in hepatocytes. RNA-seq analysis revealed that alcohol feeding increases expression of markers for tumors ( Epcam, Krt19, Prom1, Wt1, and Wwtr1), stroma ( Dcn, Fn1, and Tnc), and cytokines ( Tgfb1 and Tnf) and decreases expression of Fgf21 and Il6 in the pancreatic tumor tissues. Immunostaining showed heterogeneous expression of nephronectin, S100 calcium-binding protein A6, and vascular cell adhesion molecule 1 in pancreatic tumors surrounded by podoplanin-positive stromal cells. Our data indicate that moderate alcohol drinking is a risk factor for development of PDAC. NEW & NOTEWORTHY Heavy alcohol intake has been suspected to be a risk factor of pancreatic ductal adenocarcinoma (PDAC) in humans. However, the contribution of moderate alcohol intake to PDAC development remains elusive. In the present study, we experimentally show that moderate alcohol feeding significantly induces advanced stages of pancreatic intraepithelial neoplasia development and invasive PDAC in Pdx1Cre;LSL- KrasG12D mutant mice. Our data indicate that moderate alcohol drinking is a risk factor for PDAC.

Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients

2005 ◽  
Vol 11 (5) ◽  
pp. 323-328 ◽  
Author(s):  
Adam C. Salisbury ◽  
John A. House ◽  
Mark W. Conard ◽  
Harlan M. Krumholz ◽  
John A. Spertus
Keyword(s):  
Heart Failure ◽  
Health Status ◽  
Alcohol Intake ◽  
Heart Failure Patients ◽  
Moderate Alcohol Intake

Effect of a moderate alcohol intake on the lipoproteins of normotriglyceridemic obese subjects compared with normoponderal controls

Metabolism ◽  
1992 ◽  
Vol 41 (8) ◽  
pp. 856-861 ◽  
Author(s):  
M. Hagiage ◽  
C. Marti ◽  
D. Rigaud ◽  
C. Senault ◽  
F. Fumeron ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Obese Subjects ◽  
Moderate Alcohol Intake

scholarly journals Glucose Tolerance during Moderate Alcohol Intake: Insights on Insulin Action from Glucose/Lactate Dynamics

2002 ◽  
Vol 87 (3) ◽  
pp. 1233-1238 ◽  
Author(s):  
Angelo Avogaro ◽  
Richard M. Watanabe ◽  
Lucia Gottardo ◽  
Saula de Kreutzenberg ◽  
Antonio Tiengo ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Insulin Action ◽  
Alcohol Intake ◽  
Moderate Alcohol Intake

scholarly journals Moderate Alcohol Intake and Risk of Functional Decline: The Health, Aging, and Body Composition Study

2009 ◽  
Vol 57 (10) ◽  
pp. 1767-1775 ◽  
Author(s):  
Cinzia Maraldi ◽  
Tamara B. Harris ◽  
Anne B. Newman ◽  
Stephen B. Kritchevsky ◽  
Marco Pahor ◽  
...  
Keyword(s):  
Body Composition ◽  
Alcohol Intake ◽  
Functional Decline ◽  
Body Composition Study ◽  
Health Aging ◽  
Composition Study ◽  
Moderate Alcohol Intake

Abstract P076: Racial Differences in Maintaining Optimal Healthy Lifestyles Until 50 Years of Age: Prospective Data From the Coronary Artery Risk Development in Young Adults Study

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
John N Booth ◽  
Norrina B Allen ◽  
David Calhoun ◽  
April P Carson ◽  
Luqin Deng ◽  
...  
Keyword(s):  
Physical Activity ◽  
Coronary Artery ◽  
Racial Differences ◽  
Alcohol Intake ◽  
Smoking Status ◽  
Vigorous Physical Activity ◽  
Healthy Lifestyles ◽  
Diet Adherence ◽  
Blacks And Whites ◽  
Moderate Alcohol Intake

Introduction: Racial disparities in healthy lifestyles may begin in youth and increase over the lifespan. Hypothesis: Maintaining healthy lifestyles until 50 years of age will be lower in blacks compared with whites. Methods: The population-based Coronary Artery Risk Development in Young Adults (CARDIA) study enrolled 5115 blacks and whites aged 18-30 years in 1985-1986. Eight exams were completed over 25 years of follow-up. At each exam, optimal lifestyles were defined as body mass index (BMI) < 25 kg/m 2 , never smoking status, moderate or vigorous physical activity ≥ 150 minutes per week, no or moderate alcohol intake (drinks per week [women / men]: 0-7 / 0-14) and Dietary Approaches to Stop Hypertension (DASH) adherence score ≥ 15. Optimal cardiovascular health (CVH) was defined as having ≥ 4 optimal lifestyles. The age-specific percentage of blacks and whites maintaining optimal lifestyles was calculated using a modified Kaplan Meier method. Hazard ratios (HR) were calculated for maintaining optimal lifestyles over 25 years in blacks compared with whites. Results: At the baseline exam, 4900 participants (mean age: 26 years; black: 51%) had ≥ 1 optimal lifestyle. By 50 years of age, maintaining BMI < 25 kg/m 2 , never smoking status, moderate or vigorous physical activity ≥ 150 minutes per week, DASH diet adherence and optimal CVH were lower in blacks versus whites while maintaining no or moderate alcohol intake was higher ( Table ). The multivariable adjusted HR (95% confidence interval) comparing blacks to whites for maintaining BMI < 25 kg/m 2 was 0.57 (0.52-0.63), never smoking status was 0.82 (0.66-1.01), moderate or vigorous physical activity ≥ 150 minutes per week was 0.83 (0.76-0.91), no or moderate alcohol intake was 1.19 (1.03-1.37), DASH diet adherence was 0.71 (0.61-0.82) and optimal CVH was 0.63 (0.56-0.72). Conclusion: Blacks were less likely to maintain optimal lifestyles until 50 years of age. Reducing racial differences in the maintenance of optimal CVH may help prevent racial disparities in cardiovascular disease.

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