A Review On Expedient Assets Of Polymers Employed In Novel Topical Formulation For Successful Treatment Of Arthritis

2020 ◽  
Vol 04 ◽  
Author(s):  
Suchitra Nishal ◽  
Vikas Jhawat ◽  
Parmita Phaugat
Keyword(s):  
Rheumatoid Arthritis ◽  
Targeted Delivery ◽  
Treatment Strategies ◽  
Polymeric Materials ◽  
Cartilage Regeneration ◽  
Skin Penetration ◽  
Topical Formulation ◽  
Improved Stability ◽  
Parenteral Formulations

Background: An autoimmune ailment rheumatoid arthritis (RA) where body’s defense system is violated by damaging its own joints. In RA treatment strategies, attempts had been made for oral, topical and parenteral formulations with different drugs, but none of the formulation could be regarded as perfect dosage form. In the current review, meticulous discussion has been done for the suitability of novel topical formulation in treatment of RA. Moreover emphasize has been made on activities of biodegradable polymers such as hyaluronic acid, lecithin, pluronic acid, chitosan, human serum albumin (HSA) and poly lactide glycolic acid (PLGA) as well as their role in the management of RA. Objective: To apprehend the role of polymeric materials in developing ideal topical drug delivery system which can bestow targeted delivery, enhanced penetration of drug, improved stability of the formulation and improved PKPD profile of the drugs. These polymers possess twinfold functions, primarily by increasing the skin penetration and secondarily by improving the joint mobility and cartilage regeneration. Furthermore, biocompatibility and biodegradbility are the features which amplifies the use of aforementioned polymers. Results: Significant role of all the polymers in improving the conditions of bones and joints suffering from rheumatoid arthritis, has been demonstrated by various studies.

scholarly journals Nanotechnology: A New Hope for the Cure of Osteoarthritis, Osteoporosis and Rheumatoid Arthritis

2020 ◽  
Vol V (I) ◽  
pp. 25-39
Author(s):  
Fariah Qaiser ◽  
Muhammad Ibrahim ◽  
Rabia Mazhar ◽  
Farhan Sohail
Keyword(s):  
Rheumatoid Arthritis ◽  
Targeted Delivery ◽  
Treatment Strategies ◽  
Promising Strategy ◽  
Advanced Technologies ◽  
Efficient Delivery ◽  
Causal Treatment ◽  
Cartilage Diseases ◽  
And Cartilage

Bone and cartilage diseases especially osteoporosis, osteoarthritis and rheumatoid arthritis are rapidly prevailing both in men and women particularly due to increase in life expectancies. Different treatments are being proposed using conventional drugs and their modifications. But the side effects associated with such drugs and difficulty in treatment strategies due to multifactorial nature of such diseases and difficulty in drug delivery led the researchers towards the development of more advanced technologies for the treatment purpose. Nanotechnology is a promising strategy for treating such diseases that suppresses the progression of such diseases providing causal treatment. In this review, we will summarize the recent nano-based targeted and non-targeted delivery systems using various types of nanoparticles, nanogels, nanocomplexes, nanocarriers, hydrogels etc. for the efficient delivery of drugs and other therapeutic agents like mRNA, genes, insulin-growth factors etc. Moreover, role of nanoparticles for bone and cartilage repair in tissue engineering will also be discussed.

scholarly journals Mitochondria: Potential Targets for Osteoarthritis

2020 ◽  
Vol 7 ◽  
Author(s):  
Xingjia Mao ◽  
Panfeng Fu ◽  
Linlin Wang ◽  
Chuan Xiang
Keyword(s):  
Mitochondrial Function ◽  
Treatment Strategies ◽  
Cartilage Regeneration ◽  
Cartilage Degeneration ◽  
Research Field ◽  
Mitochondrial Dysfunctions ◽  
Joint Disorder ◽  
Global Status ◽  
Novel Treatment Strategies

Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by cartilage degeneration and narrow joint spaces. The role of mitochondrial dysfunction in promoting the development of OA has gained much attention. Targeting endogenous molecules to improve mitochondrial function is a potential treatment for OA. Moreover, research on exogenous drugs to improve mitochondrial function in OA based on endogenous molecular targets has been accomplished. In addition, stem cells and exosomes have been deeply researched in the context of cartilage regeneration, and these factors both reverse mitochondrial dysfunctions. Thus, we hypothesize that biomedical approaches will be applied to the treatment of OA. Furthermore, we have summarized the global status of mitochondria and osteoarthritis research in the past two decades, which will contribute to the research field and the development of novel treatment strategies for OA.

Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway

Nanomedicine ◽  
2021 ◽  
Author(s):  
Eleesha Sana ◽  
Mahira Zeeshan ◽  
Qurat Ul Ain ◽  
Ashraf Ullah Khan ◽  
Irshad Hussain ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Skin Penetration ◽  
Sustained Drug Release ◽  
In Vitro Techniques ◽  
Dermal Tissue ◽  
Pro Inflammatory Cytokines

Aim: To fabricate and evaluate curcumin-loaded transfersomes (Cur-TF) for the targeted delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid arthritis (RA). Methods: Modified thin-film hydration method was used to prepare Cur-TF which were then embedded into carbopol-934 gel. They were further evaluated through in vitro techniques and in an in vivo arthritis model. Results: Cur-TF had optimal particle size, spherical morphology, high encapsulation efficiency and sustained drug release profiles. The Cur-TF gel had better in vitro skin penetration than plain curcumin. In vivo findings demonstrated improved clinical, histological and x-ray scores and reduced pro-inflammatory cytokines through NF-κβ inhibition. Conclusion: Cur-TF gel delivered curcumin to the arthritic dermal tissue through a topical route and demonstrated promising therapeutic efficacy by significantly alleviating complete Freud's adjuvant (CFA)-induced arthritis.

Treatment Modalities of Psoriasis: A Focus on requisite for Topical Nanocarrier

2020 ◽  
Vol 20 ◽  
Author(s):  
Arya Kadukkattil Ramanunny ◽  
Sheetu Wadhwa ◽  
Divya Thakur ◽  
Sachin Kumar Singh ◽  
Rajesh Kumar
Keyword(s):  
Targeted Delivery ◽  
Treatment Strategies ◽  
Topical Delivery ◽  
Therapeutic Outcome ◽  
Treatment Modalities ◽  
First Line ◽  
Comparative Review ◽  
Appropriate Therapy ◽  
Selection Of

Background and Objective: Psoriasis is an autoimmune skin disease involving cascading release of cytokines activated by the innate and acquired immune system. The increasing prevalence rate of psoriasis demands for more appropriate therapy. The existing chemical moiety is promising for the better therapeutic outcome but the selection of a proper channel for administration has to be reviewed. Hence there is a need to select the most appropriate dosage form and route of administration for improving the curative rate of psoriasis. Results: A total of 108 systematic reviews of research and review articles was carried to make the manuscript comprehensible. The role of inflammatory mediators in the pathogenesis of the disease is discussed for a better understanding of the selection of pharmacotherapy. The older and newer therapeutic moiety with its mode of administration for psoriasis treatment has been discussed. With a comparative review on topical and oral administration of first-line drugs such as methotrexate (MTX), cyclosporine (CsA), and betamethasone, its benefits-liabilities in the selected routes were accounted for. Emphasis has also been given towards advanced nanocarriers for dermatologic applications. Conclusion: For better therapeutic outcome, proper selection of drug moiety with its appropriate administration is the major requisite. With the advent of nanotechnology, the development of nanocarrier for dermatologic application has been successfully demonstrated in positioning the systemically administrated drug into topical targeted delivery. In a nutshell, to achieve successful treatment strategies towards psoriasis, there is a need to focus on the development of stable, non-toxic nanocarrier for topical delivery. Inclusion of the existing orally administered drug moiety into nanocarriers for topical delivery is proposed, in order to enhance therapeutics payload with reduced side effects which serves as a better treatment approach for relief of the psoriasis condition.

Baboon Fibrinogen Adsorption and Platelet Adhesion to Polymeric Materials

1991 ◽  
Vol 65 (05) ◽  
pp. 608-617 ◽  
Author(s):  
Joseph A Chinn ◽  
Thomas A Horbett ◽  
Buddy D Ratner
Keyword(s):  
Platelet Adhesion ◽  
Coagulation Factor ◽  
Polymeric Materials ◽  
Platelet Suspension ◽  
Perfusion Chamber ◽  
Static Conditions ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Fibrinogen Adsorption

SummaryThe role of fibrinogen in mediating platelet adhesion to polymers exposed to blood plasma was studied by comparison of the effect of plasma dilution on fibrinogen adsorption and platelet adhesion, and by the use of coagulation factor deficient plasmas. Polyetherurethane substrates were first preadsorbed with dilute plasma, then contacted with washed platelets suspended in a modified, apyrase containing Tyrode’s buffer. Platelet adhesion was studied under static conditions in Multiwell dishes, and also under shearing conditions using a parallel plate perfusion chamber. Fibrinogen adsorption and platelet adhesion were measured using 125I radiolabeled baboon fibrinogen and min radiolabeled baboon platelets, respectively. Surfaces were characterized by electron spectroscopy for chemical analysis (ESCA).When fibrinogen adsorption to Biomer was measured after 2 h contact with a series of dilute plasma solutions under static conditions, a peak in adsorption was observed from 0.26% plasma, i.e., adsorption was greater from 0.26% plasma than from either more or less dilute plasma. A peak in subsequent platelet adhesion to the plasma preadsorbed surfaces, measured after 2 h static incubation with washed platelets, was also observed but occurred on Biomer preadsorbed with 1.0% plasma.When fibrinogen adsorption was measured after 5 min contact under shearing conditions, the fibrinogen adsorption peak occurred on surfaces that had been exposed to 1.0% plasma. A peak in platelet adhesion to these preadsorbed surfaces, measured after 5 min contact with the platelet suspensions under shearing conditions, was observed on Biomer preadsorbed with 0.1% plasma. Shifts between the positions of the peaks in protein adsorption and platelet adhesion occurred on other polymers tested as well.Platelet adhesion was almost completely inhibited when baboon and human plasmas lacking fibrinogen (i. e., serum, heat defibrinogenated plasma, and congenitally afibrinogénémie plasma) were used. Platelet adhesion was restored to near normal when exogenous fibrinogen was added to fibrinogen deficient plasmas. Adhesion was also inhibited completely when a monoclonal antibody directed against the glycoprotein IIb/IIIa complex was added to the platelet suspension. Platelet adhesion to surfaces preadsorbed to von Willebrand factor deficient plasma was the same as to surfaces preadsorbed with normal plasma.While it appears that surface bound fibrinogen does mediate the initial attachment of platelets to Biomer, the observation that the fibrinogen adsorption and platelet adhesion maxima do not coincide exactly also suggests that the degree of subsequent platelet adhesion is dictated not only by the amount of surface bound fibrinogen but also by its conformation.

Role of Innate Immune Sensors, TLRs, and NALP3 in Rheumatoid Arthritis and Osteoarthritis

2014 ◽  
Vol 24 (4) ◽  
pp. 243-251 ◽  
Author(s):  
Yuya Takakubo ◽  
G. Barreto ◽  
Yrjo T. Konttinen ◽  
H. Oki ◽  
Michiaki Takagi
Keyword(s):  
Rheumatoid Arthritis ◽  
Innate Immune
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