Gel - A new drug dosage form for Ayurved medicines

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Neky Mehta
Keyword(s):  
Dosage Form ◽  
Water Solubility ◽  
Raw Materials ◽  
Drug Dosage ◽  
Water Soluble ◽  
New Drug ◽  
Convenient Form ◽  
Water Based ◽  
Drug Dosage Form

Rasashastra and Bhaishajya Kalpana is the science dealing with processing of Ayurved medicines. Due to globalisation of Ayurved science it is need of time to convert our dosage form into palatable and convenient form towards the patient without compromising the effect of the medicines. So here an attempt was made to convert a medicine Rasakarpura Drava into new dosage form Rasakarpura Gel. It is also thought that other raw materials like Tuttha, Sphatika, Tankan etc; some water soluble formulations like Rasakarpura etc; and some water based dosage form like Arka, Hima, Phant etc. can be converted into gel form due to its water solubility and external skin absorbent nature. Is it possible?

Development of New Drug Dosage Form

BMJ ◽  
1972 ◽  
Vol 1 (5799) ◽  
pp. 569-569 ◽  
Author(s):  
S. S. Davis ◽  
M. Mitchard
Keyword(s):  
Dosage Form ◽  
Drug Dosage ◽  
New Drug ◽  
Drug Dosage Form

Spectrophotometric Methods for Simultaneous Determination of Sofosbuvir and Ledipasvir (HARVONI Tablet): Comparative Study with Two Generic Products

2017 ◽  
Vol 100 (4) ◽  
pp. 976-984 ◽  
Author(s):  
Nisreen F Abo-Talib ◽  
Mohamed R El-Ghobashy ◽  
Marwa H Tammam
Keyword(s):  
Dosage Form ◽  
Drug Dosage ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision ◽  
Significant Difference ◽  
Drug Dosage Form ◽  
Generic Products ◽  
Third Derivative ◽  
Combination Pill

Abstract Sofosbuvir and ledipasvir are the first drugs in a combination pill to treat chronic hepatitis C virus. Simple, sensitive, and rapid spectrophotometric methods are presented for the determination of sofosbuvir and ledipasvir in their combined dosage form. These methods were based on direct measurement of ledipasvir at 333 nm (due to the lack of interference of sofosbuvir) over a concentration range of 4.0–14.0 µg/mL, with a mean recovery of 100.78 ± 0.64%. Sofosbuvir was determined, without prior separation, by third-derivative values at 281 nm; derivative ratio values at 265.8 nm utilizing 5.0 µg/mL ledipasvir as a divisor; the ratio difference method using values at 270 and 250 nm using 5.0 µg/mL ledipasvir as a divisor; and the ratio subtraction method using values at 261 nm. These methods were found to be linear for sofosbuvir over a concentration range of 5.0–35.0 µg/mL. The suggested methods were validated according to International Conference on Harmonization guidelines. Statistical analysis of the results showed no significant difference between the proposed methods and the manufacturer's LC method of determination with respect to accuracy and precision. These methods were used to compare the equivalence of an innovator drug dosage form and two generic drug dosage forms of the same strength.

The characteristics of novel dosage forms

2003 ◽  
Vol 57 (10) ◽  
pp. 424-436 ◽  
Author(s):  
Jela Milic-Askrabic ◽  
Slobodan Petrovic
Keyword(s):  
Drug Delivery ◽  
Active Substance ◽  
Dosage Form ◽  
Technological Development ◽  
Drug Carriers ◽  
Drug Dosage ◽  
Primary Objective ◽  
Material Development ◽  
Conventional Drug ◽  
Drug Dosage Form

The objective of pharmaceutical-technological development is to find a procedure of transforming an active substance (a drug) into a drug dosage form which is not only acceptable for application, but also enables the active substance to be released following administration, pursuant to therapy objectives. The aim is that the concentration of the active substance in the action location rapidly reaches a therapeutic level and maintains an approximately constant level in the course of a particular time, according to the established therapeutic goal. The primary objective is to present the active ingredient (drug) in the form and concentration/quantity that enables the corresponding therapeutic response, i.e. to control the site and rate of medicinal substance release from the drug, as well as the rate at which it reaches the membranes and surfaces to which it is absorbed, while applying a common method of administration. The procedures used to achieve this goal are becoming highly complex and demanding and are aiming at sophisticated drug delivery systems and functional packaging material. Development from the existing drug molecule, through the conventional drug dosage form, to a new system of drug "delivery" (novel delivery system), can improve the drug (active substance) characteristics significantly in view of compliance (acceptability by the patient), safety and efficiency. The paper presents an overview of the most important examples of pharmaceutical forms with controlled release and advanced drug "carriers".

Audit of Typical Prescription Format Among the Prescribers of a Garment Medical Centre in Bangladesh

2013 ◽  
Vol 1 (2) ◽  
pp. 07-12
Author(s):  
Mohammad Afsan ◽  
Muhammad Mahbubul Alam ◽  
Nushrat Noor ◽  
Abul Kalam Mohyammad Yousuf ◽  
MM Ekramul Haque
Keyword(s):  
Dosage Form ◽  
Essential Medicine ◽  
Drug Dosage ◽  
Medical Centre ◽  
Fixed Dose ◽  
Duration Of Treatment ◽  
Cross Sectional ◽  
Garment Workers ◽  
Common Diagnosis ◽  
Drug Dosage Form

Objective: To audit the typical prescription or general format according to WHO guidelines for good prescription writing.Materials and methods: A cross-sectional descriptive study was conducted after collecting data from medical records to observe standard of prescriptions and identify factors underlying inappropriate prescription writing.Place and period of study: A total of 300 prescriptions of the patients (garment workers) who had attended in Hannan Textile and Garment Medical Centre, Board Bazar, Dhaka, Bangladesh in between January and November’2008 were considered for analysis. Results: Audit of the prescription pattern revealed that most of the prescriptions did not conform to the pattern of a typical prescription. The patient’s identity was mentioned in all prescriptions (100%). Date of the prescription and superscription symbol (Rx) were also mentioned in all prescriptions (100%). Inscription which includes name of the drug, dosage form and total amount of medication prescribed was mentioned in all prescriptions (100%) but dose and duration of treatment were mentioned in 66% and 70% prescriptions respectively. In this study, about 91.67% instructions to the pharmacist and 50% special instructions to the patient regarding the dosage form and total amount to be dispensed were found adequately. Almost 100% of the prescriptions adequately mentioned the dosage schedules and also precautions/warnings about the drug therapy. Almost 100% of the prescriptions were signed by the doctors mentioning their full name, address with qualification and registration number. But telephone/mobile number of the doctors was not found in all prescriptions (100%). Most common diagnosis among garment workers was ARI (19.33%). Most commonly prescribed group of drug was antiulcerent (17.13%) and most commonly prescribed antibiotic was amoxicillin (13.67%). Most of the drugs were prescribed in oral form (97.77%). No single drug interaction (0%) was found in any prescription. The fixed dose-drug combinations (FDCs) accounted for 67% drugs prescribed. The most commonly FDC was multivitamin and multimineral which was not included in essential medicine list (EML).Conclusion: Large numbers of prescriptions did not conform to ideal pattern and lack in their rationality. This study revealed a lot of scope for educating the prescribers to improve prescribing practices.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13979 Update Dent. Coll. j. 2011: 1(2): 07-12

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