Determination of Ratio and Stability Constant of DNA/RNA in Human Cancer Cells and Cadmium Oxide (CdO) Nanoparticles Complexes Using Analytical Electrochemical and Spectroscopic Techniques

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
A Heidari
Keyword(s):  
Stability Constant ◽  
Cancer Cells ◽  
Human Cancer ◽  
Cadmium Oxide ◽  
Spectroscopic Techniques ◽  
Human Cancer Cells ◽  
Cdo Nanoparticles

scholarly journals The effect of temperature on cadmium oxide (CdO) nanoparticles produced by synchrotron radiation in the human cancer cells, tissues and tumors

2018 ◽  
Vol 6 (2) ◽  
pp. 140 ◽  
Author(s):  
Alireza Heidari
Keyword(s):  
Synchrotron Radiation ◽  
Cancer Cells ◽  
Human Cancer ◽  
Cadmium Oxide ◽  
Radiation Pulse ◽  
Effect Of Temperature ◽  
Radiation Emission ◽  
Human Cancer Cells ◽  
Cdo Nanoparticles ◽  
532 Nm

In this work, the effect of temperature of the ablation environment on the properties of Cadmium Oxide (CdO) nanoparticles produced by synchrotron radiation is investigated. To produce nanoparticles, synchrotron radiation pulse with 1064 (nm) wavelength is used to emit Cadmium in the human cancer cells, tissues and tumors. All test parameters were kept constant and human cancer cells, tissues and tumors temperature was changed to produce samples at 20°C and 65°C. Then, ATR–FTIR, XRD, TEM and UV–Visible spectroscopy analyses were performed to investigate their properties. The results show that the size of nanoparticles is increased by increase in temperature of ablation environment. In addition, in the current experimental research, Gold (Au)–Cadmium Oxide (CdO) alloy is created at the size of nano. In this regard, same volume of Gold and Cadmium Oxide (CdO) solutions were mixed together and emitted by the synchrotron radiation pulse with wavelength of 532 (nm). The Gold and Cadmium Oxide (CdO) solutions have been produced, separately, using synchrotron radiation ablation process. To produce them, synchrotron radiation pulse with wavelength of 1064 (nm) and pulse width of 7 (ns) and repeating frequency of 5 (Hz) was used. The results show that synchrotron radiation emission with wavelength of 532 (nm) is an appropriate method for producing Gold compounds in the size of nano.  

scholarly journals Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells

2014 ◽  
Vol 42 (19) ◽  
pp. e152-e152 ◽  
Author(s):  
Simin Öz ◽  
Günter Raddatz ◽  
Maria Rius ◽  
Nadja Blagitko-Dorfs ◽  
Michael Lübbert ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Cancer Cells ◽  
Human Cancer ◽  
Mutation Rates ◽  
Human Cancer Cells

Synthesis of New Calixarene Derivatives and Evaluation of Their Cytotoxic Activity

2021 ◽  
Author(s):  
Mehmet Oguz ◽  
Ayse Yildirim ◽  
Irem Mukaddes Durmus ◽  
Serdar Karakurt ◽  
Mustafa Yilmaz
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Carcinoma Cells ◽  
Spectroscopic Techniques ◽  
Dependent Manner ◽  
Human Cancer Cells ◽  
H Nmr ◽  
Cancerous Cells ◽  
Dose Dependent ◽  
Derivatives Of

Abstract Since calixarenes are more easily synthesized and functionalized than other supramolecules, they are compounds of interest in organic chemistry. In this study, the dihydrazide (3a and 3b) and diamino propyl (6a and 6b) derivatives of p-tert-butylcalix[4]arene and calix[4]arene were synthesized. Then the L-proline methyl ester substituted chlorocyclopropenium was reacted with the calix[4]arene derivatives (3a, 3b, 6a, and 6b) at room temperature in CH2Cl2 to obtain calix[4]arene superbase derivatives (4a, 4b, 7a, and 7b) in 75%, 60%, 70% and 55% yield, respectively. The synthesized compounds' structure was elucidated by using spectroscopic techniques (FTIR, 1H NMR, and 13C NMR ). The cytotoxic properties of the calix[4]arene superbase derivatives were investigated against different human cancerous cells, including A549, DLD-1, HEPG2, and PC-3, as well as human healthy epithelium cell line PNT1A. The cytotoxicity results showed that calix[4]arene superbase derivatives inhibited the proliferation of DLD-1, A549, HEPG2, and PC-3 cells in a dose-dependent manner. Compound 7a had the highest toxic effect on colorectal carcinoma (IC50: 4.7 µM), and the IC50 values were 18.5 µM and 74.4µM against human prostate and lung cancer cells, respectively. Furthermore, the compound 4b was found more effective on hepatocellular carcinoma cells (IC50: 210.2 µM). As a result, the synthesized calix[4]arene superbase derivatives can be developed to treat different human cancer cells. They can be considered as a preliminary result for molecular-level research.

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