Multivariate analysis of a nucleophilic aromatic substitution by real-time on-line flow reaction monitoring using miniaturized mass spectrometry

2018 ◽  
Vol 04 ◽  
Author(s):  
Christopher Harris
Keyword(s):  
Mass Spectrometry ◽  
Multivariate Analysis ◽  
Real Time ◽  
Nucleophilic Aromatic Substitution ◽  
Reaction Monitoring ◽  
Aromatic Substitution ◽  
Line Flow ◽  
On Line ◽  
Flow Reaction

High-throughput polymer screening in microreactors: boosting the Passerini three component reaction

2017 ◽  
Vol 8 (19) ◽  
pp. 2972-2978 ◽  
Author(s):  
Joris J. Haven ◽  
Evelien Baeten ◽  
Jonathan Claes ◽  
Joke Vandenbergh ◽  
Tanja Junkers
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
High Throughput Screening ◽  
Reaction Monitoring ◽  
Esi Ms ◽  
Electrospray Ionisation ◽  
Ionisation Mass Spectrometry ◽  
Three Component Reaction ◽  
On Line ◽  
Ionisation Mass

The Passerini three-component reaction (Passerini-3CR) has been studied via on-line microreactor/electrospray ionisation mass spectrometry (MRT/ESI-MS) reaction monitoring to demonstrate the high-throughput screening potential of microreactors for macromolecular design.

On-Line Reaction Monitoring and Mechanistic Studies by Mass Spectrometry: Negishi Cross-Coupling, Hydrogenolysis, and Reductive Amination

2014 ◽  
Vol 126 (23) ◽  
pp. 6041-6045 ◽  
Author(s):  
Xin Yan ◽  
Ewa Sokol ◽  
Xin Li ◽  
Guangtao Li ◽  
Shiqing Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Reductive Amination ◽  
Cross Coupling ◽  
Reaction Monitoring ◽  
Mechanistic Studies ◽  
On Line

scholarly journals Synthesis of Novel Fluorescent Sensors Based on Naphthalimide Fluorophores for the Highly Selective Hg2+-Sensing

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yordkhuan Tachapermpon ◽  
Pornthip Piyanuch ◽  
Narupon Prapawattanapol ◽  
Kanjarat Sukrat ◽  
Kullatat Suwatpipat ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescent Sensors ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
One Pot ◽  
H Nmr ◽  
Sensitivity And Selectivity ◽  
New Sensors ◽  
Interfering Ions ◽  
C Nmr

With an aim to develop the new sensors for optical detection of Hg2+ions, two novel fluorometric sensors were designed and successfully prepared using 2-(3-(2-aminoethylsulfanyl)propylsulfanyl)ethanamine and one or twoN-methylnaphthalimide moieties (1and2). Sensor1was obtained viaN-alkylation,N-imidation and a one-pot nucleophilic aromatic substitution, andN-formylation of the amine, while sensor2was prepared viaN-alkylation,N-imidation, and nucleophilic aromatic substitution. The characterization, including1H NMR,13C NMR, and mass spectrometry, was then performed for1and2. The Hg2+-binding behaviors of the sensors were investigated in terms of sensitivity and selectivity by fluorescence spectroscopy. Sensor1especially provided the reversible and highly Hg2+-selective ON-OFF fluorescence behavior by discriminating various interfering ions such as Pb2+, Co2+, Cd2+, Mn2+, Fe2+, K+, Na+, and in particular Cu2+and Ag+with a detection limit of 22 ppb toward Hg2+ions.

scholarly journals N-[4-(1-Methyl-1H-imidazol-2-yl)-2,4′-bipyridin-2′-yl]benzene-1,4-diamine

Molbank ◽  
10.3390/m1030 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1030 ◽  
Author(s):  
Dhafer Zinad ◽  
Dunya AL-Duhaidahaw ◽  
Ahmed Al-Amiery ◽  
Abdul Kadhum
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
High Performance ◽  
Nucleophilic Aromatic Substitution ◽  
Gas Chromatography Mass Spectrometry ◽  
Aromatic Substitution ◽  
Target Compound ◽  
Chromatography Mass Spectrometry ◽  
Snar Reaction ◽  
Layer Chromatography

N-[4-(1-Methyl-1H-imidazol-2-yl)-2,4′-bipyridin-2′-yl]benzene-1,4-diamine was synthesized with a good yield by the reaction of 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine with 4-phenylenediamine. The functionalization of the pyridine was accomplished by a nucleophilic aromatic substitution (SNAr) reaction that afforded the target compound. The synthesized compound was characterized by chemical analysis, which includes nuclear magnetic resonance (NMR) (1H-NMR and 13C-NMR), Thin Layer Chromatography-Mass Spectrometry (TLC-MS), high- performance liquid chromatography (HPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and elemental analysis.

scholarly journals Real-time monitoring of the reaction between aniline and acetonylacetone using extractive electorspray ionization tandem mass spectrometry

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Xinglei Zhang ◽  
Miaorong Pei ◽  
Debo Wu ◽  
Shuiping Yang ◽  
Zhanggao Le
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Real Time ◽  
Sample Pretreatment ◽  
Direct Analysis ◽  
Molecular Ions ◽  
Tandem Mass ◽  
Monitoring Method ◽  
On Line ◽  
Ionization Tandem Mass Spectrometry

AbstractIn this work an on-line monitoring method was developed to study the mechanism of acetic acid catalyzed reaction between aniline and acetonylacetone using extractive electorspray ionization-tandem mass spectrometry (EESI-MS). The signals of reactants, intermediates and various byproducts were continuously detected as a function of reaction time. The chemical assignment of each signal was done via multi-stage collision induced dissociation (CID) analysis, and the reaction mechanism between aniline and acetonylacetone was deduced based on the generated molecular ions and fragment ions. The results indicate that on-line EESI-MS is an effective technique for the real time analysis of chemical reactions. EESI avoids off-line sample pretreatment and provides “soft” ionization, which allows direct analysis of various analytes at molecular level.

Sign in / Sign up

Export Citation Format

Share Document