Morphometric Characteristics and Features of Metachronous Breast Cancer

An important morphological criterion for the development of the degree of malignancy of breast cancer is the change in the structure of cell nuclei. At the same time, both the morphometric parameters of metachronous breast cancer and their connection with the molecular biological characteristics of these tumors are currently unknown. The objective of the research was to identify metachronous malignant disease in the patients with breast cancer. Materials and methods. The study is based on a retrospective analysis of tumors in 63 patients with breast cancer, who developed uterine cancer or ovarian cancer within 5 years after diagnosis of breast cancer. All the patients received treatment at the Ivano-Frankivsk Regional Clinical Oncology Center. The criterion for selecting patients in the study was the presence of gynecologic cancer after the treatment of breast cancer. The age of patients with breast cancer involved in the study ranged from 24 to 83 years, averaging 56.8±1.5 years. Results and discussion. The maximum values of the perimeter, radius, and area of cell nuclei (19.21±0.7, 3.05±0.4 and 36.3±0.9, respectively) were observed in tumors of the patients with metachronous breast cancer. The improvement of the perimeter, radius, and area of tumor cell nuclei in the patients with metachronous breast cancer was associated with an increase in the size of the tumors and the presence of metastases in regional lymph nodes. Conclusions. The morphometric sign of the high risk of developing metachronous breast cancer is the increase in the perimeter, radius, and cell nucleus area on the background of increased proliferative activity of low-grade cancer in the presence of large tumors and metastases in regional lymph nodes.

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Breast Cancer Clinical Regional Lymph Nodes TNM Finding v8

10.32388/akyy54 ◽

2020 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Regional Lymph Nodes

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Hybrid volumetric-modulated arc therapy for postoperative breast cancer including regional lymph nodes: the advantage of dosimetric data and safety of toxicities

Journal of Radiation Research ◽

10.1093/jrr/rraa057 ◽

2020 ◽

Vol 61 (5) ◽

pp. 747-754

Author(s):

Yoshiko Doi ◽

Minoru Nakao ◽

Hideharu Miura ◽

Shuichi Ozawa ◽

Masahiro Kenjo ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Irradiation Dose ◽

Organs At Risk ◽

Volumetric Modulated Arc Therapy ◽

Conformity Index ◽

Regional Lymph Nodes ◽

Dosimetric Data ◽

Arc Therapy

ABSTRACT To improve the homogeneity and conformity of the irradiation dose for postoperative breast cancer including regional lymph nodes, we planned Hybrid volumetric-modulated arc therapy (VMAT), which combines conventional tangential field mainly for the chest area and VMAT mainly for the supraclavicular area and marginal zone. In this study, we compared the dosimetric impact between traditional 3D conformal radiotherapy (3DCRT) and Hybrid VMAT and observed toxicities following Hybrid VMAT. A total of 70 patients indicated between October 2016 and December 2017 were included. The prescribed dose was 50 Gy/25 fractions. For the dosimetric impact, 3DCRT and Hybrid VMAT plans were compared in each patient with respect to the dosimetric parameters. Toxicities were followed using the Common Terminology Criteria for Adverse Events version 4.0. The median follow-up duration was 319 days. For the dosimetric impact, the homogeneity index (HI) and conformity index (CI) of PTV were significantly improved in the Hybrid VMAT plan compared with that in the 3DCRT plan (HI, 0.15 ± 0.07 in Hybrid VMAT vs 0.41 ± 0.19 in 3DCRT, P < 0.001; CI, 1.61 ± 0.44 in Hybrid VMAT vs 2.10 ± 0.56 in 3DCRT, P < 0.001). The mean irradiated ipsilateral lung dose was not significantly different in both plans (12.0 ± 2.4 Gy in Hybrid VMAT vs 11.8 ± 2.8 Gy in 3DCRT, P < 0.533). Regarding toxicity, there were no patients who developed ≥grade 3 acute toxicity and ≥grade 2 pneumonitis during the follow-up. Hybrid VMAT for postoperative breast cancer including regional lymph nodes was a reasonable technique that improved the homogeneity and conformity of the irradiation dose to the planning target volume while keeping the irradiation dose to organs at risk to a minimum.

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Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A Study of 161 708 Cases of Breast Cancer From the SEER Program

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2013-0435-oa ◽

2014 ◽

Vol 138 (8) ◽

pp. 1048-1052 ◽

Cited By ~ 58

Author(s):

Arnold M. Schwartz ◽

Donald Earl Henson ◽

Dechang Chen ◽

Sivasankari Rajamarthandan

Keyword(s):

Breast Cancer ◽

Prognostic Factor ◽

Lymph Nodes ◽

Tumor Size ◽

Nodal Status ◽

Histologic Grade ◽

Axillary Lymph Nodes ◽

Low Grade ◽

Axillary Lymph ◽

Data Set

Context.—The appropriate staging of breast cancers includes an evaluation of tumor size and nodal status. Histologic grade in breast cancer, though important and assessed for all tumors, is not integrated within tumor staging. Objective.—To determine whether the histologic grade remains a prognostic factor for breast cancer regardless of tumor size and the number of involved axillary lymph nodes. Design.—By using a new clustering algorithm, the 10-year survival for every combination of T, N, and the histologic grade was determined for cases of breast cancer obtained from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. There were 36 combinations of TN, defined according to the American Joint Committee on Cancer, and grade. Results.—For each combination of T and N, a categorical increase in the histologic grade was associated with a progressive decrease in 10-year survival regardless of the number of involved axillary lymph nodes or size of the primary tumor. Absolute survival differences between high and low grade persisted despite larger tumor sizes and greater nodal involvement, though trends were apparent with increasing breast cancer stage. Statistical significance depended on the number of cases for each combination. Conclusions.—Histologic grade continues to be of prognostic importance for overall survival despite tumor size and nodal status. Furthermore, these results seem to indicate that the assignment of the histologic grade has been consistent among pathologists when evaluated in a large data set of patients with breast cancer. The incorporation of histologic grade in TNM staging for breast cancer provides important prognostic information.

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Surgical component of lateral and central breast cancer treatment

Kazan medical journal ◽

10.17816/kmj2021-479 ◽

2021 ◽

Vol 102 (4) ◽

pp. 479-485

Author(s):

Z M Abdurakhmanova ◽

M R Ramazanov ◽

E I Sigal

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Oxygen Saturation ◽

Cancer Treatment ◽

Comparison Group ◽

Breast Cancer Treatment ◽

Main Group ◽

Regional Lymph Nodes ◽

Hemoglobin Oxygen Saturation ◽

Arterial Blood

Aim. To improve the results of the surgical component in the treatment of a nodular form of breast cancer with lateral and central localization by analyzing hemoglobin oxygen saturation of arterial blood in the foci of breast cancer, regional lymph nodes and resection line of the breast. Methods. The study involved 175 patients with a nodular form of breast cancer with lateral and central localization (T23N12M0), including 86 in the main group and 89 in the comparison group. In the main group, hemoglobin oxygen saturation in arterial blood of the foci of breast cancer, parenchyma, pectoral muscles and regional lymph nodes was examined for spread of cancer during surgery for nodular breast cancer by using a device developed by us (patent RU 2581266). This examination was not performed in the comparison group. Histopathological examination of resection specimens revealed confirmation of the main foci of breast cancer and the presence of metastases in the regional lymph nodes and pectoral muscles of the breast. Statistical analysis of the data was performed by using the Statistica 10 software. The arithmetic mean, the standard error of the mean and the standard deviation were calculated for the quantitative indicators. Results. In the main group, 86 patients had no recurrence and metastases in the follow-up, while in the comparison group, cancer recurrence was identified in 89 patients and metastases was found during cytological and histological studies in 9 patients. Conclusion. Determination of hemoglobin oxygen saturation of arterial blood during surgery in the subclavian, axillary and subscapular lymph nodes as well as in the pectoralis major and minor muscles allows clarifying the distribution of breast cancer, specifying the scope of the operation and improving the results of the surgical component of breast cancer treatment (T23N12M0).

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Clinical, morphological, and molecular genetic predictors of metastatic lesions in the regional lymph nodes in breast cancer

Advances in molecular oncology ◽

10.17650/2313-805x-2018-5-3-8-16 ◽

2018 ◽

Vol 5 (3) ◽

pp. 8-16

Author(s):

Yu. A. Dergunova ◽

V. V. Podionov ◽

V. K. Bozhenko ◽

V. V. Kometova ◽

M. V. Dardyk

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Lymph Nodes ◽

Molecular Genetic ◽

Regional Lymph Nodes ◽

Genetic Characteristics ◽

Metastatic Lesions ◽

Genetic Predictors ◽

Node Metastases ◽

High Degree

Despite the sufficient amount of data accumulated in the literature, there are still no factors, on the basis of which it would be possible to estimate the regional lymph nodes status in breast cancer with a high degree of accuracy. The review presents literature data relating to the influence of clinicopathological, molecular-biological and genetic characteristics of primary tumor on lymph node metastases. Data of 66 foreign and Russian articles are included.

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EP-1653: Loco-regional lymph nodes irradiation in left breast cancer: a dosimetric comparison between CRT and Tomotherapy

Radiotherapy and Oncology ◽

10.1016/s0167-8140(15)41645-7 ◽

2015 ◽

Vol 115 ◽

pp. S906

Author(s):

G. Boboc ◽

M.C. Pressello ◽

J. Dognini ◽

S. Arcangeli ◽

V. Donato

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Left Breast ◽

Regional Lymph Nodes ◽

Dosimetric Comparison

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Ultrasound of Regional Lymph Nodes in Breast Cancer

Multiparametric Ultrasound Diagnosis of Breast Diseases ◽

10.1007/978-3-319-75034-7_10 ◽

2018 ◽

pp. 265-284

Author(s):

Yury Patrunov ◽

Alexander N. Sencha ◽

Ekaterina Sencha ◽

Ella Penyaeva

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Regional Lymph Nodes

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Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study

Journal of Clinical Oncology ◽

10.1200/jco.2017.77.2665 ◽

2018 ◽

Vol 36 (13) ◽

pp. 1317-1322 ◽

Cited By ~ 13

Author(s):

Reshma Jagsi ◽

Kent A. Griffith ◽

Jennifer R. Bellon ◽

Wendy A. Woodward ◽

Janet K. Horton ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Phase I ◽

Chest Wall ◽

Clinical Investigation ◽

Recurrent Breast Cancer ◽

Regional Lymph Nodes ◽

Moist Desquamation ◽

Grade 3 ◽

Recurrent Breast

Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety. Patients and Methods We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recurrent breast cancer after complete surgical resection. RT consisted of 50 Gy to the chest wall and regional lymph nodes plus a 10-Gy boost. A Bayesian time-to-event continual reassessment method escalated dose through four levels, with a 30% targeted rate of dose-limiting toxicity (DLT) measured during the 6 weeks of treatment plus 4 weeks of follow-up. DLTs were defined as confluent moist desquamation > 100 cm2, nonhematologic toxicity grade ≥ 3, toxicity that requires an RT dose delay > 1 week, absolute neutrophil count < 1,000/mm3, platelet count < 50,000/mm3, or hemoglobin < 8.0 g/dL if possibly, probably, or definitely related to study treatment. Results Five DLTs occurred: Four were moist desquamation (two each at 100 and 150 mg twice a day), and one was neutropenia (at 200 mg twice a day). The crude rate of any grade 3 toxicity (regardless of attribution) was 10% at year 1, 16.7% at year 2, and 46.7% at year 3. At year 3, six of 15 surviving patients had severe fibrosis in the treatment field. Conclusion Although severe acute toxicity did not exceed 30% even at the highest tested dose, nearly half of surviving patients demonstrated grade 3 adverse events at 3 years, which underscores the importance of long-term monitoring of toxicity in trials of radiosensitizing agents.

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