Adipokine profi le in patients with ischemic heart disease in stenting of the coronary arteries: contribution of changes in psychoemotional status

Objective: to investigate the adipokine profile’s changes, depending on the presence or absence the signs of psychoemotional disorders in the form of associated affective symptoms in patients with stable coronary heart disease (CHD) without diagnosed carbohydrate metabolism’s disorders undergoing routine percutaneous coronary intervention (PCI) with stenting, and also to assess their relationship with clinical outcomes within 1 year after hospitalization.Materials and methods: the study included 20 male patients with stable angina pectoris of functional classes II – III, hospitalized for coronary stenting. The severity of affective symptoms were being assessed. The levels markers of adiponectin, leptin, resistin in the blood plasma were determined before PCI and on the 3rd day after the operation.Results: patients with stable coronary artery disease had increase in resistin concentrations and a decrease in adiponectin levels compared with reference. The change of psychoemotional status was accompanied by an initially more expressed increase in the concentrations of plasma resistin. The resistin’s level has been signifi cantly increased on the third day after PCI in patients without depressive symptoms. The dynamics of depressive symptoms hasn’t observed during the year. Clinically unfavorable outcomes, including stent’s restenosis, re-hospitalization, and the increase in angina attacks, were recorded more oft en in patients with subclinical symptoms of depression that persisted throughout the observation period.Conclusions: the factors that negatively aff ected the cardiac prognosis were the disorders of the psychoemotional status and adipokine’s changes, including аn increasе of resistin’s and a decrease of adiponectin’s levels.

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Management of stable coronary artery disease: from evidence to clinical practice

Italian Journal of Medicine ◽

10.4081/itjm.2017.755 ◽

2017 ◽

Vol 11 (2) ◽

pp. 114 ◽

Cited By ~ 1

Author(s):

Riccardo Gerloni ◽

Luciano Mucci ◽

Tiziana Ciarambino ◽

Manuel Ventura ◽

Valeria Baglio ◽

...

Keyword(s):

Heart Disease ◽

Coronary Artery ◽

Ischemic Heart Disease ◽

Stable Coronary Artery Disease ◽

Coronary Intervention ◽

Ischemic Heart ◽

Cardiac Syndrome ◽

Percutaneous Coronary ◽

Artery Disease

Ischemic heart disease, the leading cause of death, is extremely diffuse among patients hospitalized in Internal Medicine ward so that Internist should be able to manage correctly this disease. The following review revises the most recent literature and offers a practical clinical guide to be confident on this topic. After having emphasized that clinical overview remains essential, it briefly mentions advantages and limits of different investigations, reminds readers of possible alternative etiopathogeneses of ischemic heart disease (cardiac syndrome X), reports the most appropriate medical therapy, and gives the opportunity to understand appropriateness of specialist strategies such as coronary artery by-pass grafting and percutaneous coronary intervention. Finally, it illustrates a rational and evidence-based follow-up of these patients, considering that only a small part of them should be followed by a Cardiologist. The aim of a correct management of ischemic heart disease remains to reduce mortality and improve the quality of life.

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Adipokine status in patients with stable ischemic heart disease associated with affective disorders

Clinical Practice ◽

10.17816/clinpract09354-59 ◽

2018 ◽

Vol 9 (3) ◽

pp. 54-59

Author(s):

N. P. Dorofeeva ◽

A. O. Ter-Akopyan ◽

Yu. N. Оrekhova ◽

D. N. Ivanchenko ◽

S. V. Shlyk ◽

...

Keyword(s):

Heart Disease ◽

Depressive Symptoms ◽

Coronary Artery ◽

Ischemic Heart Disease ◽

Blood Plasma ◽

Affective Disorders ◽

Stable Coronary Artery Disease ◽

Ischemic Heart ◽

Stable Ischemic Heart Disease ◽

Artery Disease

One of the factors negatively affecting the cardiac prognosis of coronary heart disease (CHD) is affective disorders of the depressive spectrum. Symptoms of depression may increase the level of systemic inflammation and promote disorders of carbohydrate metabolism by altering the synthesis and secretion of adipokines: leptin, resistin, adiponectin. The aim of this study was to assess the adipokin status in patients with stable coronary artery disease in the conditions of conservative therapy and during percutaneous coronary interventions (PCI) with stenting, including patients with depressive symptoms. The presence of depressive symptoms was accompanied by an increase in the level of resistin in the blood plasma in patients with stable ischemic heart disease. PCI with coronary artery stenting resulted in an increase in the concentration of all the adipokines: adiponectin, leptin, resistin. Stenting of coronary arteries in people with depressive symptoms led to an increase in the level of resistin, adiponectin with a decrease in the concentration of leptin in the blood plasma on the third day after the operative intervention.

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LIFE QUALITY ASSESSMENT OF PATIENTS WITH STABLE CORONARY ARTERY DISEASE AFTER MYOCARDIAL REVASCULARIZATION

Pharmacy & Pharmacology ◽

10.19163/2307-9266-2020-8-6-465-475 ◽

2021 ◽

Vol 8 (6) ◽

pp. 465-475

Author(s):

I. A. Narkevich ◽

O. D. Nemyatykh ◽

K. A. Kovaleva ◽

L. G. Ratova ◽

I. O. Trushnikova ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Coronary Arteries ◽

Stable Coronary Artery Disease ◽

Life Quality ◽

Stable Coronary Heart Disease ◽

Artery Disease ◽

Angioplasty And Stenting

The aim of this study is to assess the life quality of patients with stable coronary artery disease after angioplasty and stenting of coronary arteries at the post-hospital stage.Materials and methods. Methods of the sociological analysis (questionnaire surveys) and methods of mathematical statistics (descriptive statistics, time series method, factor and variance analyses) were used at different stages of the prospective observational study. The research materials were as follows:1458 electronic patient records with a stable coronary heart disease (SCHD) after angioplasty and stenting of coronary arteries (ASCA); 620 questionnaires filled in by patients before the surgery, 1, 6, 12 months after discharge. The statistical analysis was performed using the IBM SPSS Statistics software.Results. The results of a comprehensive survey make it possible for us to assert that during the studied period, stable good healths of cardiac surgery patients with ASCA were maintained. Within the framework of the EQ-5D-5L questionnaire, it was revealed that more than 50% of patients have no physiological problems. The results of the SAQ analysis demonstrate that 58% of the patients feel better, and more than 34% of the patients do not have shortness of breath 1 year after the surgery. A statistically significant improvement in their healths was established according to a visual analogue scale relatively to the annual observation mark (62.82 ± 20.95), which corresponds to the high results assessment of the medical technology use. At the same time, 53% of the patients notify that the treatment results meet their own expectations.Conclusion. The proposed calculation of the integrated index of patients’ treatment efficiency demonstrated by the patients with stable coronary heart disease after angioplasty and stenting of the coronary arteries is based on the results of the factor analysis. This calculation can be used to assess the efficiency of pharmacotherapy in the framework of a value-oriented approach to the treatment of a number of other pathologies.

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The polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery disease

Translational Medicine ◽

10.18705/2311-4495-2018-5-4-12-22 ◽

2018 ◽

Vol 5 (4) ◽

pp. 12-22

Author(s):

A. V. Ponasenko ◽

A. V. Tsepokina ◽

M. V. Khutornaya ◽

V. A. Dolgikh ◽

I. Yu. Malshev ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Stable Coronary Artery Disease ◽

Molecular Genetic ◽

Clinical Signs ◽

Stable Coronary Heart Disease ◽

Artery Disease ◽

Prospective Monitoring

Objective:to assess the probability of pathogenic effects OF Il-18 (IL18, IL18R1 and IL18RAP) gene polymorphism on the risk of myocardial infarction in patients with stable coronary heart disease.Materials and methods: the present study was performed with the inclusion of 260 patients with stable coronary heart disease (CHD), residents of the industrial region of Western Siberia. Molecular genetic testing was performed on nine polymorphic sites of il18, IL18R1, IL18RAP genes.Results:associations of polymorphic sites rs13015714 IL18R1 and rs917997 IL18RAP with risks of myocardial infarction were Determined (OR =1.95 (95% CI =1.06-3.58), p =0.029 and OR =2.01 (95% CI =1.11-3.64), p=0.018).Conclusion:to confirm the role of polymorphism IL18, IL18R1, IL18RAP in the pathogenesis of atherosclerosis, prospective monitoring of this group of patients is necessary to identify cases of manifestation of clinical signs in persons with adverse prognosis.

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Risk Assessment of Cardiac Events in Patients with Stable Ischemic Heart Disease After Percutaneous Coronary Intervention, Accompanied by Myocardial Damage

Translational Medicine ◽

10.18705/2311-4495-2019-6-3-15-24 ◽

2019 ◽

Vol 6 (3) ◽

pp. 15-24

Author(s):

A. V. Vorobyova ◽

B. B. Bondarenko ◽

V. A. Bart ◽

M. P. Malgina ◽

V. V. Dorofeykov ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Stable Coronary Artery Disease ◽

Myocardial Damage ◽

Coronary Intervention ◽

Ischemic Heart ◽

Cardiac Events ◽

Percutaneous Coronary ◽

Artery Disease

Background. Percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) is followed often by myocardial injury. Up to now there is no mutual agreement to the inﬂ uence of the perioperative myocardial injury on the long-term prognosis of the IHD patients.Objective. The aim of study was to assess the risk factors for the development of cardiac events in the long-term period in patients with stable coronary artery disease with myocardial damage after PCI.Materials and methods. The study included 113 patients with stable coronary artery disease who underwent planned PCI. Serum troponin levels were determined before and 24 hours after the intervention. Re-examination of patients was carried out after 12–18 months (average 15 months).Results. The post PCI Tn I level over a reference one was registered in 25 patients (22,2 %). During the follow-up period the cardiovascular events took place in 25,6 % patients: acute myocardial infarction (MI) in 3 (2,6 %), angina occurred in 23 %. One-way ANOVA revealed a signiﬁ cant value for cardiac risk events of the patient age, number of stenosed arteries, summary degree of stenosis, and their complicity, number of implanted stents. The ﬁ rst three of them were included in the ﬁ nal combination of the stepwise discriminant analysis. The general linear model of the latter detected additionally statistical signiﬁ cance of the variables “MI in the past” (before PCI) and “number of postdilatations“.Conclusion. In patients with stable ischemic heart disease, included in the study, the determining risk factors for the development of cardiac events were the prevalence and nature of the obstructive lesion of the coronary bed, age, previous myocardial infarction, and especially the performance of PCI. Myocardial damage was not identiﬁ ed as a risk factor for recurrent angina or myocardial infarction.

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