Postprandial effects of macronutrient composition meals on metabolic responses and arterial stiffness indexes in lean and obese men adults; a protocol study (Preprint)

2020 ◽  
Author(s):  
Naseh Pahlavani ◽  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Lida Jarahi ◽  
Mahsa Malekahmadi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Study Protocol ◽  
Pulse Wave ◽  
Metabolic Response ◽  
Metabolic Responses ◽  
Medical Sciences ◽  
Three Phase ◽  
Component Pulse ◽  
Protocol Study ◽  
Meal Composition

BACKGROUND Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. OBJECTIVE Objective: A three-phase parallel study will design to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol is presented METHODS Methods/design: This is a parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component, pulse wave analysis and pulse wave velocity and blood sampling. RESULTS N/A CONCLUSIONS Metabolic Responses, Macronutrients Composition, Arterial Stiffness, Study Protocol: The differences in postprandial response due to different meal composition could affect of metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement. CLINICALTRIAL Trial registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019

scholarly journals Postprandial Effects of Macronutrient Composition Meals on Metabolic Responses and Arterial Stiffness Indexes in Lean and Obese Men Adults; A Protocol Study

2020 ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Metabolic Response ◽  
Augmentation Index ◽  
Resting Energy Expenditure ◽  
Medical Sciences ◽  
Three Phase ◽  
Protocol Study ◽  
New Strategies ◽  
Meal Composition

Abstract Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. Objective: A three-phase parallel study will be designed to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol will be presented.Methods/design: This is a pilot parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) will be selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component (such as resting energy expenditure, thermic effect of feeding, respiratory quotient and substrate oxidation) and arterial stiffness indexes (such as augmentation index and pulse wave velocity) and blood sampling.Results: The study will be conducted from September 2020 to January 2021 (individual N=20). Assessment of intervention outcomes will be done in 6 hours after intervention.Conclusions: The differences in postprandial responses due to different meal composition could affect the metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement.Trial Registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019

scholarly journals Postprandial Effects of Macronutrient Composition Meals on the Metabolic Responses and Arterial Stiffness Indices of Lean and Obese Male Adults: A Protocol of pilot Study

2021 ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Pilot Study ◽  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Augmentation Index ◽  
Resting Energy Expenditure ◽  
Metabolic Responses ◽  
Medical Sciences ◽  
Objective Prior ◽  
Three Phase ◽  
Meal Composition

Abstract Background & Objective: Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices. Due to the lack of a comprehensive study that concurrently compares metabolic responses and vascular stiffness indices after receiving three different meals in lean and obese men, this pilot study has been conducted with a three-phase parallel design, aiming to investigate the effects of meal composition on the metabolic parameters and arterial stiffness indices of lean and obese adults. Materials and Methods: This pilot, parallel clinical trial has been performed on 20 male adults aged 18-35 years who are disease-free and selected based on the inclusion and exclusion criteria at Mashhad University of Medical Sciences, Iran. The subjects have completed three interventions at a one-week interval, including high carbohydrate (70% carbohydrates, 10% protein, 20% fat), high protein (30% protein, 50% carbohydrates, 20% fat), and high fat meal (50% fat, 40% carbohydrates, 10% protein). Postprandial effects have been assessed within 360 minutes after each meal, including the energy expenditure component (resting energy expenditure, thermic effects of feeding, respiratory quotient, and substrate oxidation) and arterial stiffness indices (augmentation index and pulse wave velocity). In addition, blood sampling has been performed to measure glucose, insulin, free fatty acids, and lipid profile. Results: The study has started since September 2020 and will continue until January 2021. The assessment of the intervention outcomes will be carried out six hours after the end of the intervention. Conclusion: The differences in the postprandial responses c affect the metabolic and vascular parameters due to different meal compositions, thereby providing beneficial data for the establishment of new strategies in terms of nutritional education and metabolic/vascular improvement.

scholarly journals Postprandial effects of macronutrient composition meals on the metabolic responses and arterial stiffness indices of lean and obese male adults: a protocol of a pilot study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Pilot Study ◽  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Augmentation Index ◽  
Controlled Trial ◽  
Resting Energy Expenditure ◽  
Primary Objective ◽  
Metabolic Responses ◽  
Obese Adults ◽  
Meal Composition

Abstract Background Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices, and these responses may be different in lean and obese adults. The primary objective of this study is to determine the feasibility of conducting a trial to compare the effect of three test meals in lean and obese men. Due to the lack of a comprehensive study that concurrently compares metabolic responses and vascular stiffness indices after receiving three different meals in lean and obese men, this pilot study will be conducted with a three-phase parallel design, aiming to investigate the effects of meal composition on the metabolic parameters and arterial stiffness indices of lean and obese adults. Methods This pilot, a parallel clinical trial will be performed on 24 male adults aged 18–35 years since January 2021 and will continue until March 2021 who are disease-free and selected based on the inclusion and exclusion criteria at Mashhad University of Medical Sciences, Iran. The subjects will complete three interventions at a 1-week interval, including high carbohydrate (70% carbohydrates, 10% protein, 20% fat), high protein (30% protein, 50% carbohydrates, 20% fat), and high-fat meal (50% fat, 40% carbohydrates, 10% protein). Postprandial effects will be assessed within 360 min after each meal, including the energy expenditure component (resting energy expenditure, thermic effects of feeding, respiratory quotient, and substrate oxidation) and arterial stiffness indices (augmentation index and pulse wave velocity). In addition, blood sampling will be performed to measure glucose, insulin, free fatty acids, and lipid profile. Discussion The differences in the postprandial responses can affect the metabolic and vascular parameters due to different meal compositions, thereby providing beneficial data for the establishment of new strategies in terms of nutritional education and metabolic/vascular improvement. Also, the results from this pilot study will inform intervention refinement and efficacy testing of the intervention in a larger randomized controlled trial. Trial registration Iranian Registry of Clinical Trials; code: IRCT20190818044552N1; registered on August 26, 2019

Arterial stiffness is a potential mechanism and promising indicator of orthostatic hypotension in the general population

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 423-432 ◽  
Author(s):  
Qingtao Meng ◽  
Si Wang ◽  
Yong Wang ◽  
Shixi Wan ◽  
Kai Liu ◽  
...  
Keyword(s):  
General Population ◽  
Arterial Stiffness ◽  
Orthostatic Hypotension ◽  
Operating Characteristic ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Multiple Logistic Regression Analysis ◽  
The Elderly ◽  
Baroreceptor Sensitivity ◽  
Roc Curve Analysis

Background: Orthostatic hypotension (OH) is a disease prevalent among middle-aged men and the elderly. The association between arterial stiffness and OH is unclear. This study evaluates whether arterial stiffness is correlated with OH and tests the usefulness of brachial-ankle pulse wave velocity (baPWV), an arterial stiffness marker, with regard to identifying OH. Patients and methods: A sample of 1,010 participants was recruited from the general population (64.8 ± 7.7 years; 426 men) who attended health check-ups. BaPWV and the radial augmentation index (rAI) were both assessed as the arterial stiffness markers, and OH was determined using blood pressure (BP) measured in the supine position, as well as 30 seconds and 2 minutes after standing. Results: The prevalence of OH in this population was 4.9 %. Compared with the non-OH group, both baPWV (20.5 ± 4.5 vs 17.3 ± 3.7, p < 0.001) and rAI (88.1 ± 10.8 vs 84.2 ± 10.7, p < 0.05) were significantly higher in the OH group. In the multiple logistic regression analysis, baPWV (OR, 1.3; 95 % CI, 1.106–1.528; p < 0.05) remained associated with OH. Moreover, the degree of orthostatic BP reduction was related to arterial stiffness. In addition, increases in arterial stiffness predicted decreases in the degree of heart rate (HR) elevation. Finally, a receiver operating characteristic (ROC) curve analysis showed that baPWV was useful in discriminating OH (AUC, 0.721; p < 0.001), with the cut-off value of 18.58 m/s (sensitivity, 0.714; specificity, 0.686). Conclusions: Arterial stiffness determined via baPWV, rather than rAI, was significantly correlated with the attenuation of the orthostatic hemodynamic response and the resultant OH. The impaired baroreceptor sensitivity might be the mechanism. In addition, baPWV appears to be a relatively sensitive and reliable indicator of OH in routine clinical practice.

Markers of arterial stiffness in peripheral arterial disease

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Marc Husmann ◽  
Vincenzo Jacomella ◽  
Christoph Thalhammer ◽  
Beatrice R. Amann-Vesti
Keyword(s):  
Arterial Stiffness ◽  
Peripheral Arterial Disease ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Arterial Disease ◽  
Care Physician ◽  
Additional Information ◽  
Non Invasive ◽  
Assessment Techniques ◽  
Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

A Critical Appraisal of Assessment and Evaluation Reforms At Datta Meghe Institute of Medical Sciences (Deemed to be University) From 2006 Till 2017: A Study Protocol (Preprint)

2020 ◽  
Author(s):  
Dr. Priyanka Jaiswal ◽  
Dr. Ved Prakash Mishra ◽  
Dr. Minal Chaudhary ◽  
Dr. Sunita Vagha ◽  
Dr. Sachin Damke ◽  
...  
Keyword(s):  
Study Protocol ◽  
Critical Appraisal ◽  
Evaluation Process ◽  
Outcome Analysis ◽  
Medical Sciences ◽  
User Friendliness ◽  
Assessment And Evaluation ◽  
Need Analysis ◽  
The University ◽  
Regulations And Guidelines

UNSTRUCTURED DattaMeghe Institute of Medical Sciences has been declared as Deemed to be University [DMIMS (DU)] under section 3 of UGC Act, 1996 in the year 2005. The University examinations are conducted as per the rules, regulations and guidelines issued by the various Apical councils of India from time to time. The first University exam was conducted in the year 2006. DMIMS (DU) has initiated various reforms by its own in assessment and evaluation process based on needs. For any system to thrive, it needs to be constantly upgraded and critically evaluated. Therefore, a study is undertaken with this in mind and thereby aimed at evaluation and validation of the assessment and evaluation reforms formulated and implemented at DMIMS (DU) since its inception (year 2006).Need analysis for the assessment and evaluation reforms will be carried out on the basis of feedbacks and reports received from respective stakeholders (Students, Faculty and External examiners) from time to time. Outcome analysis of the Feedbacks and reports will be done subsequently after the implementation of the assessment and evaluation reforms. Further based on the outcome analysis, reforms will be validated into following parameters: Objectivity, Responsiveness, User friendliness, Residual component (not covered in above 3 parameters)and a satisfactory index will be derived. If satisfactory index for reform is 100%, it will be concluded that reforms are well received and good to excellent in nature. Total 33 assessment and evaluation reforms have beenimplemented since year 2006. These reforms will be categorised into Pre-Examination (n=18), On Site Examination (n=05) and Post Examination (n=10), and in each category, they will befurther classified into academic (Total =15) and administrative (Total = 18) on the basis of their domain for the ease of structuring and implementation.All the 33 reforms will be validated on the basis of defined parameters. They will be found satisfactory.

Association Between White Blood Cell Counts and Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults: A Cross-Sectional Study

Angiology ◽  
2021 ◽  
pp. 000331972110211
Author(s):  
Buyun Jia ◽  
Chongfei Jiang ◽  
Yun Song ◽  
Chenfangyuan Duan ◽  
Lishun Liu ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Blood Cell ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
White Blood Cell ◽  
Pulse Wave ◽  
Final Analysis ◽  
Cross Sectional ◽  
Cell Counts ◽  
Wbc Count

Increased arterial stiffness is highly prevalent in patients with hypertension and is associated with cardiovascular (CV) risk. Increased white blood cell (WBC) counts may also be an independent risk factor for arterial stiffness and CV events. The aim of the study was to investigate the relationship between differential WBC counts and brachial-ankle pulse wave velocity (baPWV) in hypertensive adults. A total of 14 390 participants were included in the final analysis. A multivariate linear regression model was applied for the correlation analysis of WBC count and baPWV. Higher WBC counts were associated with a greater baPWV: adjusted β = 10 (95% CI, 8-13, P < .001). The same significant association was also found when WBC count was assessed as categories or quartiles. In addition, the effect of differential WBC subtypes, including neutrophil count and lymphocyte count on baPWV, showed the similar results. These findings showed that baPWV has positive associations with differential WBC counts in hypertensive adults.

scholarly journals Association of changes of pulse wave velocity and augmentation index after isometric handgrip exercise with coronary lesion extent and revascularization

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Seong Taeg Kim ◽  
Yeekyoung Ko ◽  
Jong-Wook Beom ◽  
Ki Yung Boo ◽  
Jae-Geun Lee ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Iliac Artery ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Coronary Revascularization ◽  
External Iliac Artery ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Isometric Handgrip Exercise

Abstract Background Arterial stiffness is associated with myocardial ischemia and incident coronary artery disease (CAD), and indexes of arterial stiffness are usually increased in patients with CAD. However, these indexes are often increased in elderly without CAD. Arterial stiffness in patients with CAD may become more evident after isometric handgrip exercise which increases systolic pressure and ventricular afterload. We investigated the association of the change of stiffness indexes after isometric handgrip exercise with the lesion extent of CAD and the necessity for coronary revascularization. Methods Patients who were scheduled a routine coronary angiography via a femoral artery were enrolled. Arterial waveforms were traced at aortic root and external iliac artery using coronary catheters at baseline and 3 min after handgrip exercise. Augmentation index (AIx) was measured on the recorded aortic pressure waveform, and pulse wave velocity (PWV) was calculated using the ECG-gated time difference of the upstroke of arterial waveforms and distance between aortic root and external iliac artery. Results Total 37 patients were evaluated. Both PWV and AIx increased after handgrip exercise. ΔPWV was significantly correlated with ΔAIx (r = 0.344, P = 0.037). Patients were divided into higher and lower ΔPWV or ΔAIx groups based on the median values of 0.4 m/sec and 3.3%, respectively. Patients with higher PWV had more 2- or 3-vessel CAD (69% vs. 27%, P = 0.034), and underwent percutaneous coronary intervention (PCI) more frequently (84% vs. 50%, P = 0.038), but higher ΔAIx was not associated with either the lesion extent or PCI. Area under curve (AUC) of ΔPWV in association with PCI by C-statistics was 0.70 (95% confidence interval [CI] 0.51–0.88; P = 0.056). In multiple logistic regression analysis, ΔPWV was significantly associated with PCI (odds ratio 7.78; 95% CI 1.26–48.02; P = 0.027). Conclusions Higher ΔPWV after isometric handgrip exercise was associated with the lesion extent of CAD and the necessity for coronary revascularization, but higher ΔAIx was not.

scholarly journals Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hee Haam ◽  
Young-Sang Kim ◽  
Doo-Yeoun Cho ◽  
Hyejin Chun ◽  
Sang-Woon Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Cardiovascular Risk Factors ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Urinary Metabolites ◽  
Metabolic Disturbances ◽  
Liquid Chromatograph

AbstractRecent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study included 330 Korean men and women. The brachial-ankle pulse wave velocity was measured as a marker of arterial stiffness. Urinary metabolites were evaluated using a high-performance liquid chromatograph-mass spectrometer. The brachial-ankle pulse wave velocity was found to be positively correlated with l-lactate, citrate, isocitrate, succinate, malate, hydroxymethylglutarate, α-ketoisovalerate, α-keto-β-methylvalerate, methylmalonate, and formiminoglutamate among men. Whereas, among women, the brachial-ankle pulse wave velocity was positively correlated with cis-aconitate, isocitrate, hydroxymethylglutarate, and formiminoglutamate. In the multivariable regression models adjusted for conventional cardiovascular risk factors, three metabolite concentrations (urine isocitrate, hydroxymethylglutarate, and formiminoglutamate) were independently and positively associated with brachial-ankle pulse wave velocity. Increased urine isocitrate, hydroxymethylglutarate, and formiminoglutamate concentrations were associated with brachial-ankle pulse wave velocity and independent of conventional cardiovascular risk factors. Our findings suggest that metabolic disturbances in cells may be related to arterial stiffness.

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