Prevalence and Temporal Trends Analysis of Instruments in Posttraumatic Stress Disorder using Text Mining (Preprint)

2021 ◽  
Author(s):  
Hui Zong ◽  
Binyang Hu ◽  
Yang Han ◽  
Zuofeng Li ◽  
Xiaoyan Zhang
Keyword(s):  
Clinical Trials ◽  
Posttraumatic Stress ◽  
Temporal Trends ◽  
Stress Disorders ◽  
Time Duration ◽  
Prevalence Index ◽  
Text Data ◽  
Pubmed Database ◽  
Trends Analysis ◽  
Patient Health

BACKGROUND Various instruments have been developed and applied in posttraumatic stress disorders (PTSD) for patients screening and diagnosis. OBJECTIVE The study comprehensively investigates prevalence and temporal trends of the majority instruments used in PTSD related studies. METHODS A total of 1345 clinical trials registered files from ClinicalTrials.gov and 9422 abstracts from PubMed database ranging from year 2005 to year 2020 were downloaded for this study. The instruments applied in clinical trials were manually annotated, and instruments in abstracts were recognized with exact string matching. The prevalence score of one instrument in a certain period is calculated as the number of studies divided by the number of appearance of the instrument. With the yearly prevalence index of each instrument calculated, we conducted a trends analysis and compared the index change trends between instruments. RESULTS A total of 4178 instrument synonyms were annotated, which were mapped to 1423 unique instruments. In the 16 years from 2005 to 2020, only 10 instruments were used more than once per year, the top 4 most used instruments were PTSD Checklist (PCL), Clinician Administered PTSD Scale (CAPS), Patient Health Questionnaire (PHQ) and Beck Depression Inventory (BDI). There were 18 instruments whose yearly prevalence index score exceeded 0.1 at least once during the 16 years. The changes in trends and time points of partial instruments in clinical trials and PubMed abstracts are highly consistent. The average time duration of a PTSD related trial was 1495.5 days or approximately 4 years from submission to Clinicaltrial.gov to publishment on journal. CONCLUSIONS The application of widely accepted and appropriate instruments can help improve the reliability of research results in PTSD clinical studies. With the broad text data from real clinical trials and published articles, we investigated and compared the usage of instruments in PTSD research community. We make the resource of this study available on http://bmtongji.cn:1236/scale/index.

scholarly journals The role of beta-adrenolytic drugs in treating anxiety disorders

2018 ◽  
Vol 19 (3) ◽  
pp. 209-224
Author(s):  
Żaneta Brudkowska ◽  
Małgorzata Tomczyk ◽  
Katarzyna Jusiak ◽  
Hanna Karakuła-Juchnowicz ◽  
Ewa Rudnicka-Drożak
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Anxiety Disorders ◽  
Posttraumatic Stress ◽  
Randomized Clinical Trials ◽  
Stress Disorder ◽  
Therapeutic Potential ◽  
Beta Blockers ◽  
Panic Attacks ◽  
Pubmed Database

Summary Introduction: Beta blockers are mainly used in treating cardiovascular diseases. However, it has been observed that these drugs have also an anxiolytic potential. Over the years, a number of clinical trials have been conducted aimed at determining the effectiveness of beta blockers in treating anxiety disorders. The aim of the article: The main objective of the article is to present the significance and position of adrenolytic drugs in the pharmacotherapy of anxiety disorders on the basis of available literature. Moreover, the authors also decided to take into account the data from current research results, considering the problem of side effects of using adrenolytic drugs - especially the controversial reports on their effect on the development of affective disorders. Method: An analysis was conducted of articles from Medline/PubMed database, selected on the basis of the following key words: anxiety disorders, beta blockers, adrenolytic drugs, as well as on the basis of their dates of publication: 1960-2017. In order to conduct a reliable and complete review of literature, the authors decided to include works from quite an extended period of time. The articles included in the review were published in Polish and English. Results: The review of articles concerning the treatment of anxiety disorders clearly suggests that propranolol is effective in reducing the frequency of panic attacks and the tendency for avoidance behavior in patients with agoraphobia. Other studies report on potential benefits in terms of early interventional prevention and treating posttraumatic stress disorder with propranolol. However, there is lack of randomized clinical trials concerning the therapeutic effect of other adrenolytic drugs in treating anxiety disorders. Early research works reported that (mainly lipophilic) beta blockers may have a depressogenic effect; however, the latest studies have not confirmed it. The contemporary research on the therapeutic potential of beta blockers in treating anxiety disorders is insufficient. What seems to be most promising, however, are reports concerning the desirable effects of using adrenolytic drugs in treating posttraumatic stress disorder, which implicates the necessity of conducting further research verifying the validity of their application.

scholarly journals Scaling Up: Multisite Open-Label Clinical Trials of MDMA-Assisted Therapy for Severe Posttraumatic Stress Disorder

2021 ◽  
pp. 002216782110236
Author(s):  
Julie B. Wang ◽  
Jessica Lin ◽  
Leah Bedrosian ◽  
Allison Coker ◽  
Ilsa Jerome ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Posttraumatic Stress ◽  
Clinical Supervision ◽  
Stress Disorder ◽  
The United States ◽  
Health Condition ◽  
Open Label ◽  
Adverse Health Outcomes ◽  
Ptsd Symptom Severity

Background: Posttraumatic stress disorder (PTSD) is a debilitating mental health condition associated with serious adverse health outcomes and functional impairment. Previous MDMA–assisted therapy (MDMA-AT) studies have shown promising results in single site studies. Two open-label studies tested this modality in multisite clinical trials to assess the feasibility of scaling this manualized therapy across 14 North American sites. Method: Cotherapist dyads were trained in the manualized MDMA-AT protocol and administered three experimental sessions 3 to 5 weeks apart among participants with severe PTSD. Cotherapist dyads were provided clinical supervision and evaluated for protocol adherence by centralized raters. Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) assessed change in symptoms severity. Results: Adherence rating scores were high across cotherapist dyads ( M = 95.08%, SD = 3.70%) and sites ( M = 95.23%, SD = 2.20%). CAPS-5 scores decreased following 3 MDMA-AT sessions at 18 weeks post baseline (Δ M = −29.99, Δ SD = 13.45, p < .0001, n = 37, Cohen’s d = 2.2, confidence interval [1.97, 2.47]). MDMA was well tolerated. Conclusions: These findings corroborate previous results that MDMA-AT can achieve significant improvements in PTSD symptom severity and demonstrate scalability of manualized therapy across clinic sites in the United States and Canada.

Geographic and Temporal Trends of Transmitted HIV-1 Drug Resistance Among Antiretroviral-Naïve Subjects Screening for Two Clinical Trials in North America and Western Europe

2009 ◽  
Vol 10 (2) ◽  
pp. 94-103 ◽  
Author(s):  
Sibtain Rahim ◽  
Linda M. Fredrick ◽  
Barbara A. da Silva ◽  
Barry Bernstein ◽  
Martin S. King
Keyword(s):  
Drug Resistance ◽  
Clinical Trials ◽  
North America ◽  
Western Europe ◽  
Temporal Trends ◽  
Hiv 1

scholarly journals Temporal Trends Analysis for Dengue Outbreak and Network Threats Severity Prediction Accuracy Improvement

2019 ◽  
Vol 17 (3) ◽  
pp. 122
Author(s):  
Nurfadhlina Mohd Sharef ◽  
Nor Azura Husin ◽  
Khairul Azhar Kasmiran ◽  
Mohd Izuan Ninggal
Keyword(s):  
Prediction Accuracy ◽  
Temporal Trends ◽  
Accuracy Improvement ◽  
Dengue Outbreak ◽  
Severity Prediction ◽  
Trends Analysis
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