In suspension bridge, the main cable is the major bearing member, instead of the 1770MPa cable wire normally adopted in current design, the application of cable wire strengths up to 1960MPa can lighten the dead weight, reduce the size of tower and anchorage, and shorten the construction period, obtain economical design. In this paper, a under-construction suspension bridge with span of 1688m is taken as a case-study, Comparative analyses are performed mainly focusing on basic parameters, carrying efficiency of main cable, static behavior and dynamic properties as different high strength cable are adopted in this suspension bridge. The results show that compared with 1770MPa main cable, using 1960MPa main cable in suspension bridge is benefit for improving the carrying efficiency of main cable, the steel consumption is also saved by 13%, but the vertical stiffness of the structure is reduced partly; the changes of main cable slightly affect the natural vibration frequency of girder, but have greater influences on vibration of main cable.