scholarly journals Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome

2021 ◽  
Vol 17 (6) ◽  
pp. 459-464
Author(s):  
T.L. Arkhypkina ◽  
V.A. Bondarenko ◽  
L.P. Lyubimovа ◽  
I.O. Bielkina ◽  
N.F. Velichko
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary ◽  
Resistance Index ◽  
Positive Association ◽  
Average Concentration ◽  
Ovary Syndrome ◽  
Endothelium Dysfunction ◽  
Reactive Protein ◽  
Healthy Women ◽  
Ovarian Syndrome

Background. The study was aimed to determine the correlation between the blood concentration of vitamin D and factors that influence the function of the endothelium and the hemodynamic of gonads in women with polycystic ovary syndrome (PCOS). Material and methods. Sixty women aged from 18 to 26 years were examined: 30 women with a diagnosis of PCOS and 30 healthy women. The blood serum concentration of vitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), homocysteine (Hcy), nitrites/nitrates (NOx), and arginine were investigated. Maximum systolic velocity (Vmax), resistance index (RI), and pulsatility index (PI) were measured with Doppler ultrasound. Cholecalciferol was used in a dose of 4000 IU per day for 12 weeks for the correction of deficiency of vitamin D. Results. The patients with PCOS were found to have a lower (Р < 0.001) average vitamin D than healthy women. The reduction of vitamin D concentration was combined with an increase (P < 0.001) in the average concentration of NOx and a decrease in arginine. It was found a positive association between vitamin D and arginine (r = 0.391; P < 0.05), between NOx and CRP (r = 0.432; P < 0.02), IL-6 (r = 0.476; P < 0.01), Vmax (r = 0.383; P < 0.05), RI (r = 0.369; P < 0.05), PI (r = 0.380; P < 0.05) and reverse correlation with arginine (r = –0.375; P < 0.05). It was not found an association between NOx and vitamin D (r = 0.207; P > 0.05), Hcy (r = 0.176; P > 0.05); between vitamin D and Vmax (r = 0.231; P > 0.05), RI (r = 0.201; P > 0.05), PI (r = 0.181; P > 0.05). The therapy of cholecalciferol level was accompanied by an increase (P < 0.001) in concentrations of vitamin D, arginine (P < 0.05) and a decrease in NOx (P < 0.02), IL-6 (P < 0.05), SRP (P < 0.001), Hcy (P < 0.001), Vmax (P < 0.001), RI (P < 0.001), PI (P < 0.01), quantity of antral follicles (P < 0.001), and the growth of follicles (P < 0.001). However, none of the studied indicators reached the indicators in healthy women. Conclusions. The deficiency of vitamin D is associated with increased markers of chronic inflammation, homocysteine, nitrate/nitrites, reduced concentration of arginine that provokes the development of endothelium dysfunction and, therefore, the hemodynamics disorders and folliculogenesis in the ovary.

scholarly journals Body mass index and C-reactive protein are potential predictors of asthma development in Egyptian polycystic ovary syndrome patients

2019 ◽  
Vol 38 (4) ◽  
pp. 427-436 ◽  
Author(s):  
Hebatallah Ahmed Nasser ◽  
Nermeen Zakaria Abuel Ezz ◽  
Heidi Mohamed Abdel-Mageed ◽  
Rasha Ali Radwan
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Asthma Prevalence ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Reactive Protein ◽  
25 Oh Vitamin D

Summary Background Recent studies suggest asthma prevalence in polycystic ovary syndrome (PCOS) patients. This is the first study to explore asthma prevalence among Egyptian PCOS patients. It highlighted common findings in PCOS and asthma. It investigated whether these findings could serve as potential predictors of asthma. Methods A hundred PCOS patients, sixty asthmatic patients and thirty apparently healthy females of matched age were included. Body mass index (BMI), C-reactive protein (CRP), IL-6, IgE, 25 (OH) vitamin D, testosterone and lipid profile were measured. Results Both PCOS and asthmatics had significantly higher BMI, Total cholesterol (TC), LDL-C, IgE, CRP and IL-6 (P<0.001) and lower 25 (OH) vitamin D levels (P<0.001) compared to controls. Within the PCOS group, 47 patients developed asthma with a significant increase in BMI (P=0.003), CRP and IgE levels (P<0.001) compared to non-asthmatic PCOS. Both asthmatic PCOS and asthmatics expressed elevated BMI, IgE, IL-6 and CRP levels, but with no significant difference between them. Asthmatic PCOS showed significantly higher testosterone and dyslipidemia profile. Multivariate regression revealed that BMI and CRP could predict asthma development within PCOS (OR=1.104, C.I 1.004–1.2 and OR=1, C.I. 1–1.02), respectively. Receiver operating characteristic (ROC) curve showed that BMI and CRP at a cutoff value 28.5 kg/m2 and 117.6 nmol/L respectively could differentiate between asthmatic and non-asthmatic PCOS with sensitivity 63.8 % and specificity 62% for BMI, and sensitivity and specificity of 66% for CRP. Conclusions This study shows that BMI and CRP are predictors of asthma development in Egyptian PCOS.

scholarly journals Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism

Endocrine ◽  
2021 ◽  
Author(s):  
Małgorzata Kałużna ◽  
Tomasz Krauze ◽  
Katarzyna Ziemnicka ◽  
Katarzyna Wachowiak-Ochmańska ◽  
Jolanta Kaczmarek ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ovary Syndrome ◽  
Reactive Protein ◽  
Healthy Women ◽  
Normal Ranges ◽  
Cardiometabolic Profile

Abstract Purpose Women with polycystic ovary syndrome (PCOS) present with or without biochemical hyperandrogenism (HAPCOS or non-HAPCOS, respectively). Cardiometabolic and hormonal abnormalities have been reported in women with PCOS, particularly those with hypertension. However, no direct comparison between normotensive (blood pressure <140/90 mmHg) patients with HAPCOS and non-HAPCOS has been made. This study compared different cardiovascular (CV), anthropometric, metabolic and hormonal features between normotensive patients with HAPCOS and non-HAPCOS and healthy women. Methods We consecutively recruited 249 normotensive patients with PCOS and 85 healthy eumenorrheic women to a case-control observational study. Based on blood androgen concentration, patients with PCOS were divided into HAPCOS (n = 69) or non-HAPCOS (n = 180) groups. Results Although within normal ranges, patients with HAPCOS had significantly (p < 0.05) higher peripheral and central systolic blood pressure and pulse pressure, C-reactive protein, low-density lipoprotein cholesterol, triglycerides, glucose, and insulin than subjects with non-HAPCOS, and healthy women. They also had lower N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) concentration. In contrast, their body mass index (BMI) was higher of over 4 kg/m2 than patients with non-HAPCOS and nearly 6 kg/m2 than in healthy participants. Except for BMI, statistical differences in the cardiometabolic profile were of little clinical relevance. Conclusions Young normotensive women with HAPCOS have a worse cardiometabolic profile but lower NT-proBNP concentration than patients with non-HAPCOS. Features of this profile in both PCOS groups are within ranges typical for healthy women. Increased BMI is the only clinically relevant feature differentiating hyperandrogenic from non-hyperandrogenic patients with PCOS, and healthy women.

scholarly journals Relationship of Vitamin D Deficiency to Cardiovascular and Metabolic Parameters in Women with Polycystic Ovary Syndrome

2020 ◽  
Author(s):  
Alexandra Butler ◽  
Soha R Dargham ◽  
Ahmed Abou Seif ◽  
Abeer El Shewehy ◽  
Stephen L Atkin
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Glycosylated Hemoglobin ◽  
Density Lipoprotein ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Metabolic Characteristics ◽  
Reactive Protein

Abstract Objective To determine if vitamin D deficiency (25-hydroxyvitamin D3 (25(OH)D3)), exacerbated the cardiovascular and metabolic characteristics in women with polycystic ovary syndrome (PCOS).Design Comparative cross-sectional analysis.Methods Demographic and metabolic data from women aged 18-40 years from the Qatar Biobank (QBB) (78 diagnosed with PCOS, 641 controls).Results Vitamin D deficiency (median (range)) was seen in both normal 14.0 (124) ng/ml and the PCOS cohorts 14.0 (62) ng/ml and did not differ between them. Whilst PCOS subjects were heavier with a more metabolic profile (greater systolic and diastolic blood pressure, higher levels of C-reactive protein, androgens, insulin and glycosylated hemoglobin (HbA1c) and decreased high density lipoprotein (HDL) levels, with endothelial dysfunction as determined by pulse wave velocity, there was no correlation (Pearson coefficient) of any these parameters with vitamin D for either the control or PCOS population.Conclusion Vitamin D deficiency was equally prevalent in women with and without PCOS and was not correlated to insulin resistance, metabolic or cardiovascular parameters, suggesting that vitamin D deficiency is not associated with the PCOS phenotype.

The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review

2020 ◽  
pp. 1-8
Author(s):  
Daniela Menichini ◽  
Gianpiero Forte ◽  
Beatrice Orrù ◽  
Giuseppe Gullo ◽  
Vittorio Unfer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Embryo Quality ◽  
Polycystic Ovary ◽  
Vitamin D Supplementation ◽  
Endometrial Receptivity ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
Beneficial Role

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

Association between Vitamin D and Metabolic Indexes in Patients with Polycystic Ovary Syndrome

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2453-PUB
Author(s):  
SHEN SHANMEI ◽  
LIU JIAYI ◽  
LI YIKUN ◽  
QIAO CHENGCHENG ◽  
YANG JIAMIAO ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

2013 ◽  
Vol 169 (6) ◽  
pp. 853-865 ◽  
Author(s):  
Y H M Krul-Poel ◽  
C Snackey ◽  
Y Louwers ◽  
P Lips ◽  
C B Lambalk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Clinical Trials ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Vitamin D Status ◽  
Regression Analyses ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
Weighted Means

ContextMetabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS.ObjectiveThe aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS.Design and methodsA systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature.ResultsWe found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women.ConclusionsCurrent evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

scholarly journals Adnexal Torsion during Pregnancy after Oocyte In Vitro Maturation and Intracytoplasmic Sperm Injection Cycle

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Simone Giulini ◽  
Giulia Dante ◽  
Susanna Xella ◽  
Antonio La Marca ◽  
Tiziana Marsella ◽  
...  
Keyword(s):  
In Vitro Maturation ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Adnexal Torsion ◽  
Term Pregnancy ◽  
Ovary Syndrome ◽  
Clinical Disorder ◽  
Injection Cycle ◽  
Ovarian Syndrome

We report a case of right adnexal torsion during pregnancy after an oocyte in vitro maturation and intracitoplasmic sperm injection cycle in patient with polycystic ovary syndrome. A 31-year-old woman with a typical clinical disorder of polycystic ovarian syndrome was included in an oocyte in vitro maturation program. Right adnexal torsion occurred two days after embryo transfer, and laparoscopy detorsion was successfully performed with preservation of adnexa. The patient had a full-term pregnancy and delivered a healthy infant at 40 weeks of gestation. To our knowledge this is the first report of adnexal torsion after an oocyte in vitro maturation and intracitoplasmic sperm injection program.

Serum Vitamin D Binding Protein Level Associated with Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome

2018 ◽  
Vol 51 (01) ◽  
pp. 54-61 ◽  
Author(s):  
Justyna Kuliczkowska-Plaksej ◽  
Renato Pasquali ◽  
Andrzej Milewicz ◽  
Felicja Lwow ◽  
Diana Jedrzejuk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Normal Weight ◽  
Control Group ◽  
Vitamin D Binding Protein ◽  
Ovary Syndrome

AbstractThe objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20–35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA. In the normal weight control group total, free, bioavailable 25(OH)D (p<0.001 for all) were significantly higher than in its overweight/obese counterpart, while VDBP levels were comparable. In PCOS women total 25(OH)D (p<0.001), and VDBP (p –0.006) were lower in the overweight/obese subgroups than in the normal weight ones. In both groups serum VDBP levels correlated negatively with serum insulin and positively with sex hormone binding globulin. In PCOS group, in contrast to control group, VDPB was negatively correlated with abdominal fat deposit, BMI, fasting glucose and positively with HDL. Despite lower total 25(OH)D in obese PCOS women, all women with PCOS (lean and obese) had comparable free and bioavailable 25(OH)D, which might be a result of concomitantly lowered serum VDBP levels in obese PCOS women. VDBP might play important role in the regulation of availability of active fractions of 25(OH)D in PCOS women. VDBP seems to be associated with cardiovascular risk factors such as BMI, waist circumference, visceral fat, and fasting serum insulin in women with PCOS.

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