scholarly journals APOPTOTIC INDUCTION POTENTIALS OF BACOPA MONERI AGAINST ORAL CANCER CELL LINE

2016 ◽  
Vol 9 (5) ◽  
pp. 172
Author(s):  
Keerthana Baskar ◽  
Gayathri R ◽  
Vishnu Priya V
Keyword(s):  
Oral Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Caspase 3 ◽  
Cancer Cell Line ◽  
Caspase 9 ◽  
Oral Cancer Cell ◽  
Activation Mechanisms ◽  
Oral Cancer Cell Line ◽  
Apoptotic Induction

ABSTRACTAim: To assess the apoptotic induction potentials of Bacopa monnieri against oral cancer cell.Objective: This research is done to find the apoptotic induction potentials of B. monnieri against oral cancer cell line.Background: The apoptosis is a process of programed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cellchanges and death. The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leadsto the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and theextrinsic pathway.Methods: The apoptotic induction potential of B. monnieri was studied on KB cell line by investigating the activation of caspase 3 and caspase 9.Reason: Oral cancer is a growing concern due to the changes in lifestyle. The treatment for this disease has been degraded the patient’s health bcausing various side effects. An effective treatment for the long run is necessary. Usable of herbal plants can serve to be a possible and very effectivremedy.Results: Apoptotic induction potentials of B. monnieri against oral cancer cell line were studied.Conclusion: Caspase 3 and caspase 9 was activated thus proving the apoptotic potential of B. monnieri.Keywords: Bacopa monnieri, oral cancer, apoptotic induction.

scholarly journals Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12554 ◽  
Author(s):  
Daisuke Yamamoto ◽  
Kaori Shima ◽  
Kou Matsuo ◽  
Takashi Nishioka ◽  
Chang Yan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cell Line ◽  
Ornithine Decarboxylase ◽  
Cancer Cell ◽  
Histone H3 ◽  
Cancer Cell Line ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals Dentin Sialophosphoprotein (DSPP) Gene-Silencing Inhibits Key Tumorigenic Activities in Human Oral Cancer Cell Line, OSC2

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e13974 ◽  
Author(s):  
Rajeshree Joshi ◽  
Amany Tawfik ◽  
Nneka Edeh ◽  
Veronica McCloud ◽  
Stephen Looney ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Gene Silencing ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Dentin Sialophosphoprotein ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals 7. Gene transfer using ultrasonic irradiation into the oral cancer cell line

2004 ◽  
Vol 58 (4) ◽  
pp. 125
Author(s):  
Kenjiro Iwanaga ◽  
Kazuhiro Tominaga ◽  
Kozo Yamamoto ◽  
Miho Sukedai ◽  
Toshiyuki Tsujisawa ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Oral Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ultrasonic Irradiation ◽  
Cancer Cell Line ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals Evaluation and comparison of anti-cancer activity of dapagliflozin and canagliflozin in oral cancer cell line: an in vitro study

2019 ◽  
Vol 8 (3) ◽  
pp. 473 ◽  
Author(s):  
Nenavath Vinay ◽  
Darling Chellathai David
Keyword(s):  
Oral Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Sglt2 Inhibitors ◽  
Cytotoxic Assay ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

Background: Cancer is rapidly evolving life-threatening ailment in the mankind due to changes in daily food intake and lifestyle changes. Oral carcinoma is 6th major cause of cancer death in the world and it is third major reason of cancer mortality in India. Every cell in the human body requires glucose for its metabolic energy. Besides normal cell, cancer cells also require the glucose for its endurance and multiplication. SGLT2 inhibitors which are aimed at diabetes therapy exhibited anticancer properties also in colon and pancreatic cancer lines. Present study aim is to evaluate the anticancer activity of SGLT2 inhibitors against oral cancer cell by MTT Assay.Methods: To evaluate the anticancer activity of SGLT2 inhibitors MTT Cytotoxic assay is performed as per standard protocols. Cancer cells were plated in 24-well plates and incubated at 370C with 5% CO2 condition. After convergence, samples are added to the plates in various concentrations and allowed to incubate then they are detached from the plates and cleansed with the reagents. The wells are coated with the dye and incubated. Later samples are analysed in UV-spectrophotometer.Results: Cytotoxic assay showed decrease in cell viability with increasing dose of SGLT2 inhibitors. IC50 values were determined graphically. The IC50 value of dapagliflozin is 400µg/ml and canagliflozin is 250µg/ml respectively after 24 hours of Assessment.Conclusions: The results of the current study give us an evidence that SGLT2 inhibitors dapagliflozin and canagliflozin exhibits anticancer property in Oral Cancer cell line.

Sign in / Sign up

Export Citation Format

Share Document