scholarly journals ROLE OF SERUM LIPIDS IN GALLSTONE PATHOGENESIS: A CASE–CONTROL STUDY FROM PUNJAB

2018 ◽  
Vol 11 (2) ◽  
pp. 284
Author(s):  
Apinder Kaur ◽  
Amandeep Kaur ◽  
Satbir Kaur
Keyword(s):  
Lipid Profile ◽  
Serum Lipids ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Significant Rise ◽  
Lipoprotein Cholesterol ◽  
Age Group ◽  
Lipid Parameters ◽  
Control Study

  Objective: Pathogenesis of gallstone (GS) disease is multifactorial, involving both genetic and environmental factors. The main pathogenic factor responsible for the hypersecretion of cholesterol into bile is the impaired lipid metabolism, which actually reflects the likelihood of GS formation. The study aims to determine the significance of serum lipids in the etiology of GS disease and to identify the possible confounding effects of age, gender, and body mass index (BMI) on GS disease.Methods: A case–control study was conducted on 97 ultrasonically confirmed GS cases and 92 healthy controls which were further divided on the basis of gender, age group (≥40 and <40 (y)), BMI (obese and non-obese), and number of stones (single and multiple). The serum lipid parameters were estimated using the enzymatic kit assay. The statistical analysis of the lipid parameters in relation to age, gender, obesity, and stone number was done using the Student’s t-test, Chi-square test, and Mann–Whitney U-test. p<0.05 was considered statistically significant.Results: The mean serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly higher in cases as compared to controls (p=0.0001 [95% confidence interval [CI]: 33.3–61.2] and p=0.0001 [95% CI: 36.6–64.2], respectively). The serum high-density lipoprotein cholesterol (HDL-C) level was non-significantly lower in GS patients as compared to controls (p=0.4). Obese female patients of age group ≥40 (y) had an abnormal lipid profile with a significant rise in mean TC, LDL-C, and triglycerides (TG) (p<0.05) and were at higher risk of developing the GS disease as compared to controls. However, no probable effect of abnormal lipid profile, age, gender, and BMI on increasing the number of stones was found (p>0.05).Conclusion: Abnormal lipid parameters, especially high TC and LDL-C, were found to be significantly associated with GS disease. Increased age, obesity, and female gender along with dyslipidemia altogether elevate the risk of formation of GS. The formation of single/multiple stones was not influenced by the abnormal lipid profile, age, gender, and BMI.

scholarly journals Evaluation of Lipid Profile in Patients with Cherry Angioma: A Case-Control Study in Guilan, Iran

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Abbas Darjani ◽  
Rana Rafiei ◽  
Sareh Shafaei ◽  
Elahe Rafiei ◽  
Hojat Eftekhari ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Serum Lipids ◽  
Case Control Study ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Case Control ◽  
Angiogenic Factors ◽  
Low Density ◽  
Control Study

Background. Cherry angioma is the most common type of acquired cutaneous vascular proliferation which would increase with aging due to some angiogenic factors but the exact pathogenesis is unknown. Usually angiogenic factors are synthesized in human body to compensate occlusive effects of atherogenic agents such as serum lipids. Our hypothesis was that increased levels of these angiogenic factors could be a trigger for development of cherry angioma. This study has been designed to compare frequency of dyslipidemia in subjects with and without cutaneous cherry angioma. Methods. In this case-control study, 122 cases with cherry angioma and 122 control subjects without cherry angioma were enrolled. Demographic characteristics, number of the cherry angioma lesions, and serum lipid profile were collected for all subjects. The data was analyzed using SPSS 18 software. Results. Mean levels of the total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were higher in patients with cherry angioma compared to control subjects in which differences were significant for total cholesterol, low-density lipoprotein, and triglyceride (P<0.05) but not for high-density lipoprotein level. Conclusion. Serum lipids may have a role in producing angiogenic factors and development of cherry angioma and it seems logical to evaluate lipid profile in these cases.

scholarly journals An inverse association of weight and the occurrence of asymptomatic gallbladder stone disease in Hypercholesterolemia patients in northwest China: a case-control study.

2020 ◽  
Author(s):  
Binwu Sheng ◽  
Qingbin Zhao ◽  
Mao Ma ◽  
Jianqin Zhang
Keyword(s):  
Blood Pressure ◽  
Serum Lipids ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Stone Disease ◽  
Inverse Association ◽  
Gallbladder Stone ◽  
Control Study ◽  
New Onset

Abstract Background: Despite the fact that the majority of gallstones formed in the gallbladder are mainly composed of cholesterol, as they are formed from cholesterol-supersaturated bile, and hypercholesterolemia is a common metabolic disorder, which is closely related to cardiac, hepatic, renal and other oxidative damage inflammation and necrosis , there is still no consensus regarding the contribution of blood serum lipids in the pathogenesis of gallbladder stone disease (GSD). Here, we aimed to investigate the relationship between hypercholesterolemia and the risk of new-onset asymptomatic GSD, and to determine the prevalence of factors associated with new-onset asymptomatic GSD in patients with hypercholesterolemia. Methods: In this case-control study, we enrolled 927 Chinese patients with new-onset asymptomatic gallstone disease and 845 healthy controls starting in August 2012. Patients were matched for age, gender, race, occupation, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels (FBG). Body mass index (BMI), nonalcoholic fatty liver disease (NAFLD) and serum lipids indexes were compared and the relationships between BMI, blood lipid and gallbladder stone hazards were examined by using logistic multivariate regression models. Results: The result showed a significant higher morbidity with GSD in hypercholesterolemia than non-hypercholesterolemia patients (Χ 2 =17.211, P <0.001). Of hypercholesterolemia patients, low density lipoprotein (OR=1.493, P=0.029) and NAFLD (OR=2.723, P =0.022) were significant risk factors for GSD, while male sex (OR=0.244, P=0.033), weight (OR=0.961, P =0.022), high density lipoprotein (OR=0.305, P<0.001), and FBG (OR=0.687, P =0.034) significantly negatively correlated with GSD in univariate analysis. Multivariate logistic regression indicated weakly positive correlations with NAFLD (OR=3.284, P =0.054), and significant negative correlations with weight (OR=0.930, P =0.018), HDL-c (OR=0.144, P <0.001), and GSD. Conclusion: Hypercholesterolemia acts as an independent risk factor for new-onset asymptomatic GSD, while obesity and NAFLD are synergistic factors. Interestingly, we are the first to report that elevated weight was inversely associated with GSD in patients with hypercholesterolemia. The results of this study suggest that it is crucial to control hyperlipidemia effectively first instead of weight loss which might make the situation worse，and this might be of great significance for prevention of GSD in obese patients with hyperlipidemia.

scholarly journals Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity

2019 ◽  
pp. 1-10
Author(s):  
Swati Digambar Sawant ◽  
Mukund R. Mogarekar
Keyword(s):  
Nitric Oxide ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Case Control ◽  
Lipoprotein Cholesterol ◽  
Paraoxonase 1 ◽  
P Value ◽  
Control Study

Aims: The aim of the study was to evaluate the status and diagnostic utility of PON1. (Paraoxonase-1) Arylesterase and nitric oxide as indicator of antioxidant status in preeclampsia. Study Design:  Analytical case control study. Place and Duration of Study: Sample: Department of obstretics and gynecology Department, G. M. C. Ambajogai, between July 2010 and July 2012. Methodology: We conducted a case-control study of 57 women with preeclampsia and 57 women with uncomplicated deliveries. We measured PON1 Arylesterase activity, Nitric oxide and lipid profile. Results: Serum levels of LDLc (low density lipoprotein cholesterol) are higher in cases than in controls and are statistically significant (p=0.023). However serum HDLc (high density lipoprotein cholesterol) levels are decreased significantly (p = 0.017). Serum PON1 Arylesterase showed significant decrease in cases152.68 KU/L versus controls 180.89 KU/L, p value=0.002.  Serum nitric oxide also showed significant decrease in cases 22.77 ± 4.792 umol/L versus controls 25.127 umol/L, p=0.010. PON1 Arylesterase activity is found to be positively correlated with serum HDL cholesterol (r = 0.449, p value< 0.001). Multivariate logistic regression analysis was done. Conclusion: Our observed results show decrease in the antioxidant PON1 Arylesterase activity point towards their role in the pathogenesis of Preeclampsia.

scholarly journals Maternal Lipid Profile in Preeclampsia: Case-Control Study

2021 ◽  
pp. 159-166
Author(s):  
J. O. Agbara ◽  
K. A. Rabiu ◽  
A. Gbadegesin ◽  
N. W. Okoh
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Case Control Study ◽  
Severe Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Case Control ◽  
P Value ◽  
Low Density ◽  
Control Study

Background: Preeclampsia has continued to be a challenge especially in the areas of understanding the pathogenesis and prevention or treatment of the disease. Previous reports on the relationship between maternal lipids and preeclampsia have varied as its role in the aetiopathogenesis of pre-eclampsia is not clearly defined. This study aimed at comparing the lipid profile in preeclampsia with that in normotensive pregnancy. It also examined for any relationship between an abnormal profile and severe disease. Methods: This was a prospective case-control study. It was conducted among pregnant women who presented for routine antenatal care and those seen in the emergency room of the obstetrics unit of a tertiary institution in Lagos, Nigeria.  The duration of the study was 6 months as it took place between May 2015 to October 2015. Pregnant women in their second half of pregnancy, diagnosed to have pre-eclampsia and, who gave consent were consecutively recruited as cases and pregnant women with similar age and gestational age, who had normal blood pressure were also selected as controls within the study period. The Maternal lipid profile was assayed using an enzyme-based assay kit and analysed according to the manufacturer’s instructions. All participants were followed up till delivery. Results: One hundred and seventy pregnant women in the third trimester of pregnancy participated in this study. They were within 18 – 45 years of age. More of the participants were nulliparous. Eighty-five of them had pre-eclampsia and constituted the study group while 85 were normotensive in the control group. The mean age was similar in both groups (control=29.59 ± 4.50 years versus pre-eclampsia=29.73 ± 5.10 years). The gestational ages at blood sampling of the patients in this study ranged between 27 – 40 weeks.  The analysis of data revealed that the level of total cholesterol, triglycerides, low-density lipoprotein and very-low-density lipoprotein was higher in the cases compared with the control. This difference was statistically significant because the calculated P-value was <0.05. The level of high-density lipoprotein was lower in those with pre-eclampsia. Serum cholesterol and low-density lipoprotein were significantly higher (P-value= 0.04) in those with severe disease. A significant positive relationship was observed between mean arterial blood pressure and abnormal levels of lipids. Conclusion: An abnormal pattern of lipid profile was observed in women with preeclampsia and this was more marked in those with severe disease. A larger multi-centre study will be required to substantiate this finding.

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