Smoking, Low Density Lipoprotein Cholesterol, Fibrinogen and Myocardial Infarction Before 41 Years of Age: A Danish Case-Control Study

Abstract Aim Diabetes Mellitus is associated with an increased risk of fractures, which is not explained fully by bone mineral density and common risk factors. The aim of this study is to investigate the association of medication and biochemical markers on the risk of fracture in a diabetes population. Methods Nested case-control study based on Danish diabetes patients from The Danish National Hospital Discharge Registry. The cases of the study were diabetes patients with a fracture (n= 24,349) and controls were diabetes patients with no fracture (n=132,349). A total of 2,816 diabetes patients were available for an analysis of patient characteristics, co-morbidities, biochemical parameters and drug usage. Results Patient age at the time of diabetes diagnosis, a diagnosis of previous fracture, an alcohol related diagnosis, total cholesterol level, and the usage of antidepressants, antiepileptics and insulin all increased the odds of fracture. Low-density lipoprotein cholesterol (LDL) levels decreased the odds of fracture, where the level of 3.04–5.96 mmol/l was optimal with regard to fracture risk. Conclusion LDL may add to the understanding of fractures in diabetes patients and it may be added to current fracture risk models in diabetes patients.

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Direct measurement of serum low-density lipoprotein cholesterol in patients with acute myocardial infarction on admission to the emergency room

The American Journal of Cardiology ◽

10.1016/s0002-9149(96)00170-1 ◽

1996 ◽

Vol 77 (14) ◽

pp. 1232-1234 ◽

Cited By ~ 6

Author(s):

Frederic J. Van Dis ◽

Leonard M. Keilson ◽

Clark A. Rundell ◽

Ming W. Rawstron

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Emergency Room ◽

Direct Measurement ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol

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Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio as Predictor of First Acute Myocardial Infarction and Major Adverse Cardiovascular Event after Intervention in Young Males

Chinese Medical Journal ◽

10.4103/0366-6999.240803 ◽

2018 ◽

Vol 131 (18) ◽

pp. 2239-2241 ◽

Cited By ~ 1

Author(s):

Zhao Li ◽

Shao-Jun Wen ◽

Zhi-Zhong Li ◽

Nan Li ◽

Ji Huang

Keyword(s):

Myocardial Infarction ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Major Adverse Cardiovascular Event ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Adverse Cardiovascular Event ◽

Cholesterol Ratio ◽

Young Males

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Low Density Lipoprotein Cholesterol May Be a Key Independent Risk Factor for Asymptomatic Gallbladder Stone Disease in Non-Alcoholic Fatty Liver Disease Patients in Northwest China: A Case-Control Study

10.47829/jjgh.2021.51301 ◽

2021 ◽

Vol 05 (13) ◽

Author(s):

Wan Y ◽

Ma M ◽

Zhang J ◽

Sheng B

Keyword(s):

Case Control Study ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Northwest China ◽

Case Control ◽

Stone Disease ◽

Low Density Lipoprotein Cholesterol ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease ◽

Control Study

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First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

Journal of Perinatal Medicine ◽

10.1515/jpm-2018-0120 ◽

2019 ◽

Vol 47 (2) ◽

pp. 161-168 ◽

Cited By ~ 6

Author(s):

Paula J. Correa ◽

Pia Venegas ◽

Yasna Palmeiro ◽

Daniela Albers ◽

Gregory Rice ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Case Control Study ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

First Trimester ◽

Case Control ◽

Low Density ◽

Control Study

AbstractObjectivesTo evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).MethodsThe study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).ResultsThe GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.ConclusionWomen who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.

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