scholarly journals ANTIBIOTICS SENSITIVITY TO THE PATIENTS WITH URINARY TRACT INFECTION IN PROF. DR. W. Z. JOHANNES HOSPITAL

2018 ◽  
Vol 11 (13) ◽  
pp. 171
Author(s):  
Maria Hilaria ◽  
Elisma Elisma ◽  
Ni Nyoman Yuliani ◽  
Sagabulang M
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Infections ◽  
Hospital Setting ◽  
Antibiotic Sensitivity ◽  
Klebsiella Pneumonia ◽  
E Coli ◽  
Antibiotics Sensitivity ◽  
Test Result

Introduction: Urinary tract infection (UTI) implies the presence of actively multiplying organisms in the urinary tract. Although it is infrequently associated with mortality, it is still a significant cause of morbidity. UTIs are one of the most common bacterial infections in humans both in the community and hospital setting. Objective: The objectives of this research were to know antibiotic given to patients with UTI as well as to know the percentage of antibiotic sensitivity to each bacteria causing UTI in RSUD Prof. Dr. W. Z. Johannes Kupang during January 2013–December 2013. Methods: This was a retroprospective hospital-based study conducted in collaboration with Microbiology Department in Prof. Dr. W.Z. Yohanes Hospital, Kupang, from January 2013 to December 2013. In the prior study, it was obtained data of patients with UTI that their urine cultured in Bacteriology Laboratory, RSUD Prof. Dr. W. Z. Johannes Kupang. Based on data of patients which have microbe and sensitivity test result, then it would be obtained the distribution of microbe or germ type, antibiotic sensitivity, and resistance. After that, it was conducted by data analysis. Results: Among 87 respondents, 34.5% were males and 65.5% were females. The most widely used antibiotic is ciprofloxacin (98.8%). The most sensitive antibiotic is meropenem (93.98%) to the Escherichia coli, Klebsiella pneumonia, and Enterobacteriaceae group bacteria. The most resistance antibiotic is ampicillin (87.14%). Conclusion: UTI patients are more common in women compared with men. That germ most commonly found in UTI patients is E. coli. Meropenem was sensitive to all bacterias, while ampicillin was resistance.

scholarly journals Bacteriological profile and sensitivity pattern of urinary tract infection patients in north east part of Bangladesh

2020 ◽  
Vol 7 (11) ◽  
pp. 1614
Author(s):  
Guljar Hossain ◽  
Enayet Hossain ◽  
Ferdaus Ahammed ◽  
Mohammed R. Kabir ◽  
Gobinda Karmaker ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Infections ◽  
Antibiotic Sensitivity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli ◽  
North East ◽  
Sensitivity Pattern

Background: Urinary tract infection (UTI) is one of the most important causes of bacterial infections across the globe. Increasing antibiotic resistance among urinary pathogens to commonly prescribed drugs has become a therapeutic challenge. Periodic evaluation of antimicrobial activity of different antibiotics is essential as the pattern of antibiotic sensitivity may vary over periods.Methods: This cross-sectional study was undertaken in the Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet from January 2019 to June 2019 among 100 adult patients admitted Medicine indoor Department confirmed as UTI on the basis of symptoms, signs and compatible investigation, urine culture either positive or negative.Results: Out of the total 100 urine samples 60 samples were positive for pathogenic organisms. Escherichia coli was isolated in 41 (68.3%) of the positive samples, followed by Klebsiella sp 13 (21.6%), Pseudomonas sp 3 (5%) Proteus sp 2 (3.3%) staph. Aureus 1 (1.66%). E coli was found to be most sensitive to nitrofurantoin (92.5%), meropenem (92.5%), amikacin (84.6%) and gentamycin (71.8%) and resistant to most commonly used drugs like cefixime (78%), cefuroxime (77.5%), ciprofloxacin (62.5%), ceftriaxone (62.5%).Conclusions: Mainly gram-negative bacilli are found to be responsible for UTI and most frequent isolated bacteria was E-coli. The most sensitive antibiotics were nitrofurantoin, meropenem, and amikacin& gentamycin. Frequently usedantibiotic like cefixime, cefuroxime, cotrimoxazole, ciprofloxacin & ceftriaxone were mostly resistant to E-coli.

scholarly journals Antibiotic sensitivity pattern of bacterial isolates from urine samples of admitted patients with urinary tract infection in a tertiary care teaching hospital of Tripura, India: a hospital record based study

2018 ◽  
Vol 7 (4) ◽  
pp. 585
Author(s):  
Uttam K. Das ◽  
Prithul Bhattacharjee ◽  
Shubhaleena Debnath ◽  
Maitrayee Chakraborty ◽  
Ranjib Ghosh ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Tract Infection ◽  
Teaching Hospital ◽  
Antibiotic Sensitivity ◽  
Urine Samples ◽  
Hospital Record ◽  
E Coli ◽  
Sensitivity Pattern

Background: Urinary tract infection (UTI) being one of the most common and a serious health problem both in the community and hospital settings each year worldwide, the emergence of antibiotic resistance in the management of UTI is a serious public health issue. The present study will analyse the antimicrobial sensitivity pattern of pathogens isolated from the urine samples of admitted patients suffering from UTI in Tripura Medical College and Dr. B.R. Ambedkar Memorial Teaching Hospital (TMC).Methods: This was a hospital record-based study. The urine samples of clinically diagnosed UTI patients admitted in various departments of the hospital during the study period were included. The reports of culture and sensitivity testing of the samples were collected. The results were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI).Results: During the 12-month study period, a total of 752 urine samples were analysed. Enterococcus (43.75%) was the most frequently isolated bacteria, followed by E. coli (28.45%) and Klebsiella (14.89%). Enterococcus was highly sensitive (p<0.001) to vancomycin (95.33%), E. coli was mostly sensitive to nitrofurantoin (83.65%) and Klebsiella mainly sensitive to imipenem (75.49%).Conclusions: The study showed that positive urine culture with the antibiotic sensitivity of the isolates is very important for antimicrobial therapy, as antibiotic resistance is a worldwide problem which causes ineffectiveness of treatment.

scholarly journals Comparison of empirical antibiotics used with microbiological sensitivity pattern among patients admitted with urinary tract infection

2021 ◽  
Vol 9 (2) ◽  
pp. 466
Author(s):  
Sanal K. Thomas ◽  
V. Abraham Varghese
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Resistant Organism ◽  
Klebsiella Pneumonia ◽  
E Coli ◽  
Sensitivity Pattern ◽  
Sensitivity Report ◽  
Culture And Sensitivity ◽  
Empirical Antibiotics

Background: Symptomatic Urinary tract infection (UTI) is among the most common infection described in hospital settings. Inappropriate use of antibiotics initiated before the laboratory results of urine culture contribute to increasing resistance to antibiotics in uropathogens. Awareness of the disease, knowledge of the spectrum of antibiotics and common complication of UTI will help to reduce morbidity and mortality. This study compares common empirical antibiotics used with their  clinical outcomes and microbiological sensitivity pattern among patients admitted with UTI in a tertiary care hospital.Methods: It is a cross sectional study conducted in inpatients of Pushpagiri medical college, Thiruvalla from January 2017 – June 2018. Assuming that 50% of organisms will show sensitivity to empirical antibiotic therapy with a relative precision of 20% and alpha error of 5 %. Sample size is calculated as 100. Those patient  satisfying the inclusion criteria was recruited into the study after obtaining informed consent till the sample size attained. Symptoms on the day of admission was assessed using the questionnaire for Clinical profile. Primary outcome was matching of empirical antibiotics with culture and sensitivity pattern.  Secondary outcomes were Symptom resolution on third day with empirical antibiotics and profile organisms causing UTI.Results: Majority of the population belonged to 61-80 year of age (57%). The study population had 44 percent male and 56 females.72 percent of total population was diabetic.  The most common antibiotic used to treat empirically was piperacillin –tazobactum accounting for 47.2 percent followed by ceftriaxone  45 percent. Others contributed less than 8 percent.75 percent of empirical antibiotics matched with culture and sensitivity report in the study population.The most common organisms found was Escherichia coli (61%) followed by Klebsiella pneumonia(15 %) The most common resistant organism was E Coli followed by Klebsiella pneumonia. Esbl resistance was encountered in 28 cases and carbepenamase resistance in 2 percent cases. 27 percent of diabetic patient had resistant organism infection in urine. Symptoms  of  urinary tract infections were better resolved when empirical antibiotics used had  matched microbiological sensitivity pattern.Conclusions: After the age of 60 year UTI occurred almost equal in male and females There was only 75 percent agreement with empirical antibiotics and culture sensitivity report. Resistant organism were common in the diabetic population. Most common organism encountered in symptomatic UTI is E coli. Symptomatic resolution occurred in majority of cases where the empirical antibiotic was sensitive than compared to resistant case. Some of the resistant cases had symptomatic resolution  possibly explained by the in vivo sensitivity. As the agreement with empirical antibiotics became low, hospital antibiotic policies must reviewed and changed according to resistance pattern and type of organism that is locally prevalent

scholarly journals Pattern of Bacterial Pathogens Causing Urinary Tract Infection and Their Antibiotic Sensitivity: A Tertiary Care Hospital Experience

2016 ◽  
Vol 5 (1) ◽  
pp. 20-23
Author(s):  
Raziur Rahman ◽  
Muhammad Abdur Rahim ◽  
Samira Rahat Afroze ◽  
Palash Mitra ◽  
Tabassum Samad ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
E Coli ◽  
Number Of Patients

Background and Aims: Urinary tract infection (UTI) is a common illness. The spectrum of bacteria causing UTI and their antibiotic sensitivity is not uniform. This study was designed to describe the bacteriological spectrum causing UTI and their antibiotic sensitivity.Methods: This cross-sectional study was done in the Department of Internal Medicine, BIRDEM General Hospital from January to June, 2013.Results: Total number of patients was 103 with females predominance (F:M ratio 2:1). Mean age was 57.5 years. Most (91.3%) of the study population were diabetic with poor glycaemic control (mean HbA1c 9.9%). Common symptoms were fever, dysuria, increased urinary frequency, suprapubic pain, vomiting and loin pain. Neutrophilic leukocytosis was common (94.2%). E. coli (79.6%) was the commonest aetiological agent followed by Klebsiella (9.7%), Citrobacter (3.9%), Acinetobacter (1.9%), Enterobacter (1.9%), Enterococcus (1.9%) and Pseudomonas (0.9%). Imipenem (100%), aminoglycosides e.g. amikacin and gentamycin and nitrofurantoin were among the most sensitive antibiotics.Conclusion: E. coli is the commonest organism causing UTI and imipenem, amikacin and nitrofurantoin are the most sensitive antibiotics.Birdem Med J 2015; 5(1): 20-23

scholarly journals Recent Antibiotic Sensitivity Pattern of Escherichia Coli in Urinary Tract Infection

2018 ◽  
Vol 30 (1) ◽  
pp. 61-65
Author(s):  
Md Abdul Bari ◽  
Mashiur Arefin ◽  
Moriom Nessa ◽  
Golam Mostofa ◽  
Tafiqul Islam
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urine Culture ◽  
Antibiotic Sensitivity ◽  
E Coli ◽  
Sensitivity Pattern ◽  
Marked Resistance ◽  
Culture Positive

The objective of the study is to assess the recent sensitivity pattern of Escherichia coli in Urinary tract infection (UTI). Widespread use of antibiotics has led to the emergence of resistant microorganisms. As the antibiotic sensitivity patterns of the microorganisms are frequently changing, this retrospective analysis was designed to assess the recent antibiotic sensitivity pattern of Escherichia coli (E. coli) in urinary tract infection among the human population. Details of 358 urine culture positive reports for E. coli and their antibiotic sensitivity pattern pertaining to the study period of 6 months from Jan 2017 to June 2017 were collected from Microbiology Laboratory of Diagnostic Centers at Rajshahi and the results were statistically analyzed. The antibiotics tested for sensitivity were amikacin, gentamycin, ciprofloxacin, levofloxacin, cotrimoxazole, nitrofurantoin, ceftazidime, ceftriaxone and cefixime. The sensitivity pattern of E.coli to antibiotics in UTI was amikacin (82.68 gentamycin (75.97%), nitrofurantoin (70.67), levofloxacin (44.13%), ceftazidime (42.17%), co-trimoxazole (40.78%), ceftriaxone (38.54%), ciprofloxacin (35.75%), and cefixime (24.02%). The study highlighted the marked resistance of E. coli to quinolones and third generation cephalosporins.TAJ 2017; 30(1): 61-65

scholarly journals Antibiotic Sensitivity Pattern and Plasmid Profile Of Urinary Tract Infection Isolates among Children Below 10 Years Of Age

2019 ◽  
Vol 5 (1) ◽  
pp. 58-62
Author(s):  
Ram Wagle ◽  
Rajendra Timilsina ◽  
Rojesh Thapa ◽  
Nabaraj Adhikari ◽  
Upendra Thapa Shrestha ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Sensitivity ◽  
Plasmid Profile ◽  
Plasmid Copy ◽  
Lower Urinary Tract Infection ◽  
Cross Sectional ◽  
E Coli ◽  
Sensitivity Pattern

Urinary tract infection (UTI) is defined as colonization of pathogen anywhere along the urinary tract. UTI has been classified by site of infection as Upper urinary tract infection and lower urinary tract infection and by severity as Complicated and uncomplicated UTI. This community based cross sectional study was conducted to determine the Antibiotic sensitivity pattern and plasmid profile of most prevalent urinary tract infection isolates among children below 10 years of age, from December 2013 to February 2014. Among the total 800 sample collected from the community 390(48.8%) were female and 410(51.2%) were male. The prevalence rate was found to be 44(5.5%) of total cases and was statistically significant (p<0.05). Among significant growth, 15(1.9%) and 29(3.6%) were male and female respectively (p<0.05). Out of 44 total isolates frequency of Escherichia coli (E. coli) was 20 followed by Staphylococcus aureus(12), which accounted for 45.5% and 27.3% respectively. Remaining were Pseudomonas(11.4%), Klebsiella(11.4%), Proteus(2.3%)and Citrobacter sps.(2.3%). Tobramycin(100%) and Amikacin(97.73%) were found to be the most sensitive antibiotics followed by Chloramphenicol(93.18%), Imipenem(90.91%) and Ciprofloxacin(75%) respectively.Out of 20 E. coli isolates, no plasmid was seen in 7(35%) while 8(40%) showed single plasmid which was present in 8 isolates. Plasmid copy number of 2, 3 and 4 were displayed by 2(10%), 2(10%) and 1(5%) of the isolates respectively. A common (>21 kilobases) plasmid was the most common among isolates under study. This study revealed that E. coli was the most prevalent organism causing community acquired pediatric UTI. Antibiotics that are commonly used for the management of UTI and other cases are being more resistant i.e., Ampicillin. Plasmid analysis showed the presence of plasmids in resistant E. coli isolates that might harbor resistant genes. So that further analysis is required for the detection of responsible genes. Key words: Antibiotic sensitivity pattern, Plasmid profile, Urinary tract infection

scholarly journals Molecular Epidemiologic Approaches to Urinary Tract Infection Gene Discovery in Uropathogenic Escherichia coli

2000 ◽  
Vol 68 (4) ◽  
pp. 2009-2015 ◽  
Author(s):  
Lixin Zhang ◽  
Betsy Foxman ◽  
Shannon D. Manning ◽  
Patricia Tallman ◽  
Carl F. Marrs
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Dna Sequences ◽  
Bacterial Infections ◽  
Gene Discovery ◽  
Population Characteristics ◽  
E Coli ◽  
K 12

ABSTRACT Urinary tract infection (UTI) is one of the most frequently acquired bacterial infections. The vast majority of UTIs are caused by a large, genetically heterogeneous group of Escherichia coli. This genetic diversity has hampered identification of UTI-related genes. A three-step experimental strategy was used to identify genes potentially involved in E. coli UTI transmission or virulence: epidemiologic pairing of a UTI-specific strain with a fecal control, differential cloning to isolated UTI strain-specific DNA, and epidemiologic screening to identify sequences among isolated DNAs that are associated with UTI. The 37 DNA sequences initially isolated were physically located all over the tester strain genome. Only two hybridized to the total DNA of the sequencedE. coli K-12 strain; eight sequences were present significantly more frequently in UTI isolates than in fecal isolates. Three of the eight sequences matched to genes for multidrug efflux proteins, usher proteins, and pathogenicity island insertion sites, respectively. Using population characteristics to direct gene discovery and evaluation is a productive strategy applicable to any system.

scholarly journals Antibiotic Sensitivity in UTI among Diabetic Pregnant Women

2020 ◽  
Vol 33 (1) ◽  
pp. 54-58
Author(s):  
N Naher ◽  
F Begum ◽  
N Hashem
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Standard Procedure ◽  
Antibiotic Sensitivity ◽  
Successful Outcome ◽  
E Coli ◽  
Sensitivity Pattern

Background: Urinary tract infection (UTI) is common during pregnancy and especially soin pregnant patients with diabetes mellitus. The emergence of drug resistance and particularlythe extended spectrum Beta-lactamase production by Escherechia Coli and Methicillinresistance in staphylococci, limits the choice of anti-microbials. Method: A cross-sectional study was conducted on 50 pregnant women with sign andsymptoms of UTI in the Department of Obstetrics and Gynaecology, BIRDEM generalHospital-2 from January to June 2017. The objectives of the study were to determine thepresence and type of pathogens found in pregnant diabetic women presenting with featuresof urinary tract infection, and to analyze their antibiotic sensitivity pattern. Clean catch midstreamurine samples were collected using standard procedure and culture and sensitivitywas done following standard bacteriological method. Results: Mean age of the study subjects was 29.84±5.29 yrs; 48% were in third trimester ofpregnancy; 52% had Gestational Diabetes Mellitus (GDM) and 48% had Diabetes Mellitus(DM). Out of fifty pregnant women, thirty eight (76.0%) study subjects had positive growth.Of them, Escherechia coli was found in 57.9% cases, Klebsiellain 21.1%, Staphylococcusaureus in 7.9%, Enterococcus and Pseudomonas aeruginosa each in 2.6% case. Amikacinwas found to be sensitive to 100% cases of E. Coli, Klebsiella& Enterococcus but 100%resistant to Streptococcus. Conclusion: In this study, E. Coli was the most common organisms causing UTI, which isless susceptible to conventional oral antibiotics but more susceptible to amikacin. So carefulldrug selection is required for successful outcome in UTI. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 54-58

scholarly journals Clinical Profile and Antibiotics Sensitivity in Childhood Urinary Tract Infection at Dhulikhel Hospital

2015 ◽  
Vol 11 (4) ◽  
pp. 319-324 ◽  
Author(s):  
SD Singh ◽  
SK Madhup
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urine Analysis ◽  
Antibiotic Sensitivity ◽  
Recurrent Uti ◽  
Common Drug ◽  
Micturating Cystourethrogram ◽  
Antibiotics Sensitivity ◽  
Culture Positive

Background Urinary Tract Infection implies presence of actively multiplying organisms in the urinary tract. Although it is infrequently associated with mortality, it is still a significant cause of morbidity. Early diagnosis is critical to preserve renal function of growing kidney.Objective Our purpose was to determine the clinical, microbiologic profile and antibiotic sensitivity of such infections in pediatric Urinary Tract Infection (UTI) patients at Dhulikhel Hospital.Methods A hospital based prospective descriptive study of 135 children from 2 months to 16 years, with clinical diagnosis of urinary tract infection who visited the pediatric department of Dhulikhel Hospital over the period of 15 months were enrolled in the study. All patients underwent routine urine analysis and culture. Children with recurrent UTI underwent micturating cystourethrogram (MCUG). Children with recurrent UTI of more than two years and with feature of pyelonephritis underwent USG abdomen as well. Complications and response of the treatment was observed in all cases of UTI. All data were entered in Epidata and data analysis was done using spss 16 version.Results Among 135 children, 32.5% were male and 67.4% were female. Fever was the most common presenting symptom in 74.80% of patients followed by dysuria in 54.1%. Among these children 95.6% had significant pyuria and 45% had culture positive infection. Children who showed positive for bacteriuria, Escherichia coli (78.7%) was the most common organism and are more than 80% sensitive to Amikacin, Gentamicin, Ceftriaxone, Ofloxacin, Nalidixic acid, Imipenem and Vancomycin. Co-trimoxazole was the most common drug used for treatment with a mean drug respond time of (mean±S.D) of 2.21±.78 days. 2±±. Children who had recurrent UTI were more prone to develop culture positive UTI (p=0.0001).Conclusion Urinary Tract Infection in female was almost twice more common than in male. Co-trimoxazole was the most common drug used for treatment, sensitivity of this drug was less than 50% for all organisms.Kathmandu Univ Med J 2013; 11(4): 319-324

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