scholarly journals TOXICITY STUDIES OF A DEVELOPED NEPHROPROTECTIVE POLYHERBAL FORMULATION IN EXPERIMENTAL RATS

2019 ◽  
pp. 166-169
Author(s):  
SASIKALA S ◽  
KANNIKAPARAMESWARI N
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Morphological Changes ◽  
Hematological Parameters ◽  
Term Treatment ◽  
Behavioral Pattern ◽  
Polyherbal Formulation ◽  
Toxicity Studies ◽  
Long Term Treatment

Objective: In the present study, acute toxicity studies were evaluated on scientifically developed nephroprotective polyherbal formulation. Polyherbal formulation consists of ethanolic extracts of dried plants of Boerhavia diffusa (BD) and Achyranthes aspera (AA). Materials and Methods: In an acute toxicity study, polyherbal formulation was administered once orally at doses ranging from 250 mg/kg to 2000 mg/kg for 15 days. Body weight and food consumption were noted during the study period. Behavioral pattern and toxic effects were monitored in each group of animals daily. At the end of the study, blood was withdrawn for hematology and biochemical estimations. The animals were then sacrificed, and the liver, kidney, heart, and brain were dissected out which were observed for any gross morphological changes. The weights of organs were also noted. Results: The results showed no changes in body weight, organ weight, food intake, hematological parameters, and liver function test when compared with control. The organs did not show any evidence of gross morphological changes. Conclusion: It is concluded that developed polyherbal formulation, at a dose of 2000 mg/kg, is safe for long-term treatment of kidney disorders

scholarly journals Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects

1984 ◽  
Vol 52 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Marcin Krotkiewski
Keyword(s):  
Body Weight ◽  
Dietary Habits ◽  
Guar Gum ◽  
Term Treatment ◽  
Total Serum ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Long Term Treatment ◽  
Obese Subjects

1. The effect of a palatable granulated guar-gum preparation (10 g twice daily) was studied in obese subjects. The acute effect of a single dose of guar gum to reduce the peak postprandial whole blood glucose levels (about 10%) was verified. Following long-term treatment, a further reduction was seen in the obese subjects with the highest postprandial glucose levels. Since the postprandial plasma insulin levels were essentially unchanged, this finding suggested an increased responsiveness to insulin. Total serum cholesterol levels were significantly reduced following long-term treatment but serum α-cholesterol levels, representing the high-density-lipoprotein fraction, was unchanged.2. Body-weight was significantly reduced during guar-gum treatment even though the patients were asked to maintain their normal dietary habits. Daily hunger ratings recorded for up to 10 weeks showed that guar gum reduced hunger significantly better than commercially available bran taken in the same way.3. Thus, guar gum seemed to influence carbohydrate and lipid metabolism in a beneficial way in obese subjects. The reduction in hunger would offer an additional benefit to these patients.

ACUTE AND SUBACUTE TOXICITY STUDIES OF ETHANOLIC EXTRACT OF MIRABILIS JALAPA LINN IN WISTAR ALBINO RATS

2021 ◽  
pp. 80-85
Author(s):  
SENTHIL KUMARI C ◽  
DHANASEKHAR KESAVELU
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Acute Toxicity ◽  
Lipid Profile ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Mirabilis Jalapa

Objective: The objective of the study was to evaluate the toxicological potential of the ethanolic extract of leaves of Mirabilis jalapa linn through acute and subacute toxicity studies in albino Wistar rats. Methods: For acute toxicity studies, the ethanolic extract of M. jalapa was given up to 2000 mg/kg and then the animals were observed for 14 days to find out any adverse effect or death. For sub-acute toxicity studies, the exact was given for 28 days and the following parameters were observed such as changes in body weight, food intake, water intake, hematological parameters, biochemical parameters, lipid profile, urine analysis, and histopathological studies were undertaken. Results: Single oral administration of 2000 mg/kg of the ethanolic extract of M. jalapa produced no mortality or signs of toxicity. During subacute toxicity there were no changes in body weight, food intake and water intake were observed. There were no changes in lipid profile, hematological parameters, and biochemical parameters. In histopathological changes, there were no structural changes in treated groups when compared to control. Conclusion: The leaves of ethanolic extract of M. jalapa is safe when administered for 28 days. There were no deaths or signs of toxicity in treated rats during acute toxicity studies and subacute toxicity studies.

CORTICOSTEROIDS AND VASCULAR CONNECTIVE TISSUE

1969 ◽  
Vol 60 (4) ◽  
pp. 586-594 ◽  
Author(s):  
Ib Lorenzen
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Human Skin ◽  
Term Treatment ◽  
Collagen Content ◽  
Acid Mucopolysaccharides ◽  
Long Term Treatment

ABSTRACT Male albino rabbits were injected with prednisone 2 mg/kg body weight, daily for two weeks. The aortic content of acid mucopolysaccharides and the synthesis of sulphated acid mucopolysaccharides decreased, whereas the collagen content remained unchanged as compared to the saline injected controls. Prednisone induced no gross or microscopic changes in the aortae. The alterations were related to those previously reported in human skin and vein biopsies and may be of pathogenic significance in the vascular fragility following long-term treatment with glucocorticoids.

scholarly journals Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

2009 ◽  
Vol 78 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Edson Lucas Santos ◽  
Kely de Picoli Souza ◽  
Elton Dias da Silva ◽  
Elice Carneiro Batista ◽  
Paulo J. Forcina Martins ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Life Span ◽  
Ace Inhibitor ◽  
Body Weight Gain ◽  
Term Treatment ◽  
Long Term Treatment

LONG-TERM TREATMENT WITH ORAL TORSEMIDE AND ITS EFFECT ON BODY WEIGHT AND FLUID BALANCE IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY

1996 ◽  
Vol 3 (11) ◽  
pp. 743-749
Author(s):  
Andrew Whelton ◽  
William B. Smith ◽  
J. David Wallin ◽  
Lawrence J. Hak ◽  
Barry McLean ◽  
...  
Keyword(s):  
Body Weight ◽  
Renal Insufficiency ◽  
Fluid Balance ◽  
Chronic Renal Insufficiency ◽  
Term Treatment ◽  
Long Term Treatment

1400 EFFECTS OF LONG-TERM TREATMENT WITH TESTOSTERONE UNDECANOATE INJECTIONS IN HYPOGONADAL MEN ON WAIST CIRCUMFERENCE, BODY WEIGHT AND BMI

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Dany-Jan Yassin ◽  
Ahmad Haider ◽  
Michael Zitzmann ◽  
Aksam Yassin ◽  
Peter Hammerer ◽  
...  
Keyword(s):  
Body Weight ◽  
Waist Circumference ◽  
Term Treatment ◽  
Testosterone Undecanoate ◽  
Long Term Treatment
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